Global ETD Search
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Showing 1 to 8 of 8 for “"cyclobutane pyrimidine dimers"”.
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Biochemical and Genetic Studies on Origin Recognition and DNA Synthesis From the Mesophilic Archaeon Methanosarcina Acetivorans
… was able to synthesize through abasic DNA and cyclobutane pyrimidine dimers, and these activities were stimulated by the cognate PCNA. Fascinatingly, unlike most translesion DNA polymerases previously described, MacDinB synthesized an unusually long product (∼7.2 kb) in the presence of the …
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Photolyase: Its Damaged DNA Substrate and Amino Acid Radical Formation During Photorepair
… the formation of covalent bonds between adjacent pyrimidines. Cis-syn cyclobutane pyrimidine dimers (CPD)constitute the most abundant primary lesion in DNA. Photolyase, a light-activated enzyme, catalytically repairs these lesions. Although many steps in the photolyase-mediated repair process have …
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Jednoduchý elektrochemický DNA biosenzor pro detekci poškození DNA způsobeného UV zářením
… DNA damaging agent. Major DNA lesions, such as cyclobutane pyrimidine dimers (CPDs) and pyrimidine-(6-4)-pyrimidone (6-4PPs) photoproducts, are carcinogenic and mutagenic. UV induced DNA damage was investigated using a simple electrochemical DNA biosensor based on an ultra-trace graphite …
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DNA polymerase interactions and their role In translesion synthesis substitutions.
… is capable of TLS past ultraviolet (UV)-induced cyclobutane pyrimidine dimers (CPDs) as well as cisplatin-induced Pt-GG intrastrand crosslinks. Cisplatin is a well-known cancer treatment used to damage the DNA of cancer cells by generating lesions such as the Pt-GG intrastrand crosslink. By …
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Transcription Coupled DNA Repair in Saccharomyces Cerevisiae: the Interplay of Facilitators and Repressors
… helix-distorting DNA lesions, such as UV induced cyclobutane pyrimidine dimers (CPDs) and bulky chemical adducts. Transcription coupled repair (TCR) is a subpathway of NER dedicated to rapid removal of lesions in the transcribed strand of actively transcribed genes. The TCR mechanism in bacteria …
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Identification of Novel Core and Accessory Factors Involved in Nucleotide Excision Repair in Yeast
… helix-distorting lesions, such as UV-induced cyclobutane pyrimidine dimers (CPDs). NER is traditionally grouped into two pathways: global genomic repair (GGR), which is operative throughout the genome, and transcription coupled repair (TCR), which is dedicated to rapid repair of the …
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Structural and Biochemical Investigation of the Molecular Mechanisms of DNA Response and Repair in Humans and <em>Escherichia coli</em>.
… repair of persistent DNA lesions, such as cyclobutane pyrimidine dimers. The basis for initial damage recognition in NER is structural distortion of duplex DNA; however, the effects of adduct structure and sequence on strand opening and recognition are unclear. Using the <em>E. coli</em> …
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Heat stress: A risk factor for skin carcinogenesis
… the UVB spectrum, causes formation of cyclobutane pyrimidine dimers (CPD) in cellular DNA. Persistent and incorrectly repaired CPDs lead to DNA mutations and consequently, formation of cutaneous lesions. Interestingly, recent epidemiological studies have shown a significant increase in …