Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"cyclin-dependent kinases (Cdk)"”.
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Characterization of Endothelial Nitric Oxide Synthase Serine-600 Phosphorylation
… research identifying eNOS as a substrate of cyclin-dependent kinases (CDK). CDKs are one of the regulatory elements in cell cycle progression and form a class of serine/threonine kinases. The most commonly studied and well understood posttranslational modification of eNOS is phosphorylation. …
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Ezh2 T416 Phosphorylation Enhances Breast Cancer Tumorigenesis
… yet to be elucidated. Phosphorylation of EZH2 by cyclin dependent kinases (CDK) has been reported to control EZH2 epigenetic function and thus consequently control cancer cell proliferation, invasion, and stem cell differentiation. Our group has established that EZH2 and cyclin E, the enzymatic …
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An investigation of post-translational modification of human papillomavirus E4 and the role of modified E4 proteins during the virus life cycle
… cells and is a substrate for multiple cellular kinases in vitro. The phospho-acceptor residue for cyclin-dependent kinases (CDK) 1 and 2 has been identified as threonine 23, whilst serine 58 is phosphorylated by protein kinase A (PKA). Furthermore, a cyclin binding motif (\(^{43}\)RRL\(^{45}\)) …
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The role of Cdc7 and cyclin-dependent kinases in DNA replication and S phase
… it is driven by the successive activation of cyclin-dependent kinases (Cdk) and proper coordination of cell cycle transitions and processes ensure genomic stability. DNA replication takes place during S phase to faithfully duplicate a cell’s genetic material. In eukaryotes, S phase onset …
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Quantitative Analysis of a Cell Cycle Checkpoint in Xenopus laevis Cell-Free Egg Extracts
… or damaged DNA by inhibiting the activity of cyclin-dependent kinases (Cdks). In the Xenopus laevis embryo, checkpoints are not operational until the midblastula transition (MBT). Studies in cell-free egg extracts indicate that a threshold concentration of nuclei, which approximates the MBT …
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Regulation and function of interphase histone H1 phosphorylation in pluripotent cell differentiation
… after differentiation. Selective inhibition of CDK7 and CDK9, or siRNA depletion of CDK9 rapidly diminishes both the global levels and the enrichment of pS187-H1.4 at housekeeping genes. Moreover, inhibiting transcription with actinomycin D induces the accumulation of pS187-H1.4 at promoters and …