Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"cyclin-dependent kinase inhibitors"”.
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Role of Cyclin-Dependent Kinase Inhibitors in Estrogen Regulation of Adipogenesis
… has an effect on the levels of cell cycle inhibitors like p27 Kip1 (p27) and p21 Cip1 (p21) in breast cancer cell lines, estrogen might have an effect on the number of adipocytes by its effect on these proteins. Lack of p27 and p21 caused obesity due to hyperplasia in mice, which led to …
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DESIGN AND SYNTHESIS OF PURINE BASED NEUROPROTECTORS AND NOVEL SYNTHETIC METHODS FOR THE TRIFLUOROMETHYLATION OF ALDEHYDE HYDRAZONES
… compounds are widely investigated as cyclin-dependent kinase inhibitors that have broad applications in the design of pharmaceuticals for treating diseases, such as diabetes, atherosclerosis, and cancers. Towards the goal of effective AGE-inhibitors, and neuroprotector compounds we …
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The role of p27 phosphorylation in mediating atRA sensitivity of ovarian carcinoma cells
… including the retinoblastoma family of proteins, cyclin dependent kinases (Cdks), and cyclin dependent kinase inhibitors. P27, a cyclin dependent kinase inhibitor regulating G1 checkpoint has been shown to have elevated levels in response to atRA treatment. In these studies we investigated the …
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The role of anchorage in cell cycle control
… known as anoikis, due to activation of anchorage-dependent checkpoint mechanisms. Transformed cells alleviate these checkpoints, via activation of oncogenes and/or inactivation of tumour suppressors. In contrast, detachment of normal cells halts cell-cycle progression in G1, because of …
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SCF SKP2B - AND KPC1-DEPENDENT DEGRADATION OF CYCLIN-DEPENDENT KINASE INHIBITOR KRP1 AND CELL CYCLE REGULATION IN ARABIDOPSIS THALIANA
In animals and fungi, cyclin-dependent kinase inhibitors play a key role in cell cycle regulation by inhibiting the activities of cyclin-dependent kinase/cyclin complexes. However, little is known about the role of this group of proteins in plant cell cycle regulation. To gain insight into the …
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The Effect of Endothelin-1 on the expression of CDK Inhibitors p21 & p27 in Bovine Corneal Endothelial Cells
… was to determine whether the down regulation of cyclin dependant kinase inhibitors (p21cip1 and p27kip1) levels by Endothelin-1 (ET-1), would overcome the G1 phase arrest and promote cell cycle progression and proliferation in cultured BCECs (Bovine corneal endothelial cells). BCECs were isolated …
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Atp-Citrate Lyase Links Cyclin E to Cellular Metabolism In Breast Cancer
<p>Cyclin E is altered or overexpressed in approximately one-third of tumors from patients with invasive breast cancer and is a powerful independent predictor for survival in women with stage I-III breast cancer. Full-length cyclin E (EL) is post-translationally cleaved into two …
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The Role and Mechanism of The Homeobox Gene Dlx4 In Transforming Growth Factor-B Resistance In Cancer
… program that includes activation of the cyclin-dependent kinase inhibitors p15<sup>Ink4B</sup> and p21<sup>WAF1/Cip1</sup> and repression of c-myc. In contrast to normal cells, many tumors are resistant to the anti-proliferative effect of TGF-b. In several types of tumors, particularly …
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Notch signaling and cell cycle inhibitor regulation in pituitary organogenesis
… pituitary. HES1 transcriptional repression of Cyclin Dependent Kinase Inhibitors (CDKI) is the mechanism by which HES1 promotes cell cycle progression. Loss of Hes1 in the developing pituitary, results in increased expression of the CDKIs p21, p27 and p57. We hypothesize that this aberrant …
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The mechanisms underlying mechanical cell competition and leader cell migration in mammalian epithelia
… p53 and its effector p21 (and potentially other cyclin-dependent kinase inhibitors) are the key drivers of leader cell migration. I demonstrate that p53-induced leaders use the same molecular pathways that have been shown to drive leader cell migration during wound healing and, in fact, p53 and …
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Characterization of novel small molecule inhibitors of FOXM1 as potential therapeutic agents for breast cancer
… cancers. Despite this compelling evidence, no inhibitors of FOXM1 that have therapeutic potential have emerged due to lack of specificity and potency, and importantly, poor pharmacokinetic profiles in animals. To this end, we have identified and characterized novel inhibitors of FOXM1 that …
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Probing the Role of Nascent Helicity in Protein Function: p27kip1 as a Regulator of the Cell Cycle
… binds to and regulates the activity of cyclin-dependent kinases (Cdks) which are the master timekeepers of the cell division cycle. Members of the p27 family of proteins, also including p21 and p57, are called cyclin-dependent kinase inhibitors (CKIs). The amino terminal domain of p27 …
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Axis of placental ageing in adverse pregnancy outcomes
… genes in the placentas was performed by RTqPCR. Cyclin-dependent kinase inhibitors (p21 and p16) expression were determined by Western blotting. Senescence Associated Secretory Phenotype (SASP) were evaluated in maternal plasma by multiplex ELISA assay. Proteomic analysis of placental samples …
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Soybean lunasin mediates colon carcinogenesis by inducing apoptosis and preventing outgrowth of metastasis
… of lunasin to increase the expression of cyclin dependent kinase inhibitors p21 and p27. At 10 µM, lunasin increased the expression of p21 and p27 in KM12L4 colon cancer cells by 2.2- and 2.3-fold, respectively. Flow cytometric analysis showed that lunasin at 10 µM increased the percentage …
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Regulation of the anti-senescence factor, TBX2, by the UV stress signaling pathway and the mitotic cyclin dependent kinases
… can suppress senescence through repressing the cyclin dependent kinase inhibitors, p21wAF11 c1 P118011 and p19ARF. Both Tbx2 and Tbx3 have also been linked to several cancers primarily because their expression levels have been found to be deregulated in these cancers. However, despite the …
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Regulation of the anti-senescence factor, TBX2, by the UV stress signalling pathway and the mitotic cyclin dependent kinases
… can suppress senescence through repressing the cyclin dependent kinase inhibitors, p21wAF11 c1P118011 and p19ARF. Both Tbx2 and Tbx3 have also been linked to several cancers primarily because their expression levels have been found to be deregulated in these cancers. However, despite the pivotal …