Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"cyclin-dependent kinase inhibitor"”.
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Regulation of the cyclin-dependent kinase inhibitor p21 by TBX3
… evidence suggest that TBX3 may repress the cyclin-dependent kinase inhibitor p21WAF1, which has a role in a myriad of processes including cell cycle arrest, senescence, apoptosis, differentiation and DNA replication and repair. The current study therefore aimed to explore this possibility …
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Functional characterization of the cyclin-dependent kinase inhibitor p21 by gene targeting in the mouse
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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SCF SKP2B - AND KPC1-DEPENDENT DEGRADATION OF CYCLIN-DEPENDENT KINASE INHIBITOR KRP1 AND CELL CYCLE REGULATION IN ARABIDOPSIS THALIANA
In animals and fungi, cyclin-dependent kinase inhibitors play a key role in cell cycle regulation by inhibiting the activities of cyclin-dependent kinase/cyclin complexes. However, little is known about the role of this group of proteins in plant cell cycle regulation. To gain insight into the …
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Multiple Levels of Regulation of Cyclin-dependent Kinase Inhibitor 1A (p21/WAF-1) by the <i>DDX5 </i>Gene
… helicases, exhibits both ATPase and RNA helicase dependent/independent activities. To date the p68 protein has been implicated in most parts of RNA metabolism including ribosome biogenesis, transcription, RNA decay, miRNA processing and pre-mRNA processing. Alterations in both expression and …
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P27 Expression in Endothelin-1 Stimulated Mitogenesis
… mitogenic activity is mediated through the cyclin dependent kinase inhibitor p27. BCEC were isolated from bovine eyes and grown in DMEM-10% serum in a 5% C02, 37° C incubator. Confluent cultures of BCEC were incubated for 24 hours with lOOnM Endothelin-1, luM BQ123 and BQ123 +100nM …
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Expression des Zellzyklus-Inhibitors p27 KIP1 in Leiomyomen und Leiomyosarkomen
… cycle regulators and tumor suppressors, such as cyclin dependent kinase inhibitors (cdkIs), has been reported in malignant tumors. The current study was undertaken to examine the involvement of a cdkI p27KIP1 leiomyoma and leiomyosarcoma. Immunohistochemical staining was performed on 41 samples …
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The roles of human cytomegalovirus US27 gene product during virus infection
… down-regulation of cell cycle regulators CDKN1A (cyclin dependent kinase inhibitor 1A) and SESN2 (Sestrin2 or Hi95). These results indicate that increased cell proliferation due to US27 may be linked to suppression of negative growth regulators. In addition, US27 was shown to increase calcium …
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The ageing hair follicle environment. Alterations in the female scalp and mesenchyme with age.
… Metallopeptidase 1 (MMP1) and Metallopeptidase inhibitor 1 (TIMP1), cyclin-dependent kinase inhibitor 2A (p16INK4A), 11β-Hydroxysteroid dehydrogenase type 1 and 2 (11β-HSD1/HSD11B1 and 11β-HSD2/HSD11B2) mRNA expression increased in aged DFs. In DS cells, HAS2, Vimentin (VIM) ,PDPN, …
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The role of anchorage in cell cycle control
… known as anoikis, due to activation of anchorage-dependent checkpoint mechanisms. Transformed cells alleviate these checkpoints, via activation of oncogenes and/or inactivation of tumour suppressors. In contrast, detachment of normal cells halts cell-cycle progression in G1, because of …
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The role of p27 phosphorylation in mediating atRA sensitivity of ovarian carcinoma cells
… including the retinoblastoma family of proteins, cyclin dependent kinases (Cdks), and cyclin dependent kinase inhibitors. P27, a cyclin dependent kinase inhibitor regulating G1 checkpoint has been shown to have elevated levels in response to atRA treatment. In these studies we investigated the …
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MEIS1: At the Crossroads Between Metabolic and Cell Cycle Regulation
… cardiomyocytes through induction of synergistic cyclin dependent kinase inhibitor families. We demonstrate that both embryonic and adult deletion of Meis1 in cardiomyocytes results in widespread cardiomyocyte proliferation in the adult heart. Overall, our studies identify Meis1 as a critical …
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The Function and Regulation of Senescent Stromal-Derived Osteopontin
… modulation and ectopic expression of p27, a cyclin-dependent kinase inhibitor. However, my work on the transcriptional activation of OPN reveals that SASP contains distinct subsets governed by unique transcriptional mechanisms. To this end, I demonstrate that OPN, unlike IL6 and IL8 - two …
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Targeted Inhibition of Pi3K, Mtor, and Igf1R For The Treatment of Undifferentiated Pleomorphic Sarcoma
… that members of the phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) signaling pathway can be used to predict patient outcome in cohorts containing patients with various subtypes of soft tissue sarcoma. Furthermore, we have previously shown that high levels of …
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Mechanism of Human Papillomavirus E6-Mediated Repression of P53-Target Gene *Transcription
… employed by DNA tumor viruses to inhibit p53-dependent transcription is poorly understood. Here we describe a new paradigm for human papillomavirus (HPV) E6 oncoprotein-mediated repression of human p21 WAF1 cyclin-dependent kinase inhibitor gene transcription, independent of its well known …
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Covalent modification and intrinsic disorder in the stability of the proneural protein Neurogenin 2
… in mammalian cell lines, resulting in cell cycle-dependent regulation of stability. I will then discuss whether phosphorylation, a regulator of xNgn2 activity, also affects xNgn2 stability. I will provide evidence of cell cycle-dependent phosphorylation of cyclin dependent kinase (cdk) consensus …
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Overcoming radioresistance by targeting p21 in cancer
… cellular responses mainly regulated by p53. The cyclin-dependent kinase inhibitor p21 (CDKN1A), also known as p21WAF1/Cip1, is the main p53 transcriptional target and it is traditionally recognized as a tumor suppressor since it is involved in genomic stability preservation, cell cycle arrest or …
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Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia
… mediated gene silencing. Interestingly, the cyclin dependent kinase inhibitor p15 was found to be methylated at a high frequency in AML patients and cell lines in association with a lack of detectable p15 mRNA. Treatment with the cytosine analog 5-Aza-2’-deoxycytidine (5-Aza-dC) in vitro …
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Roles of CCN5 in regulating progression and therapeutic sensitivity of breast cancer
… resulting in transcriptional activation of the cyclin-dependent kinase inhibitor P27KIP1. Also, we found that the CCN5-induced PI3K-AKT inactivation leads to stabilization and nuclear accumulation of P27KIP1 resulting in cell cycle arrest of TNBC cells. Next, we have shown that CCN5 protein can …
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Developing Constrained p27 Peptides to Target the Oncogenic E3 Ubiquitin Ligase SCF-Skp2
… substrates. A major target of SCF-Skp2 is the cyclin-dependent kinase inhibitor p27 which positively regulates cell cycle progression. Elevated levels of Skp2 and reduced levels of p27 are common in a variety of cancers, including lymphomas and breast and prostate carcinomas. A lack of suitable …
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Mechanisms of cell senescence: p21 and DNA damage response in aging and longevity
… stress response is indeed p21, an induction of cyclin-dependent kinase inhibitor which triggers cell growth arrest associated with senescence and damage response and notably is involved in the up-regulation of multiple genes that have been associated with senescence or implicated in age-related …
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