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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 23 for “"cyclin-dependent kinase (Cdk)"”.

  1. Identification of novel regulators of mitotic exit in Saccharomyces cerevisiae

    D'Aquino, Katharine EMassachusetts Institute of Technology2006

    … cell into two daughter cells is controlled by cyclin dependent kinase (CDK). Entry into mitosis is promoted by the activity of CDK complexed with mitotic cyclins. Upon faithful segregation of a full complement of DNA between each daughter cell, exit from mitosis proceeds. In order for cells to …

    mit Repository record

  2. Mechanisms that prevent DNA re-replication in the yeast Saccharomyces cerevisiae

    Tanny, Robyn EMassachusetts Institute of Technology2006

    … or origins, across the genome. Examples of both Cyclin-Dependent Kinase (CDK)-dependent and CDK-independent mechanisms have been identified that regulate the components of the pre-Replicative Complex (pre-RC) to prevent re-replication. The pre-RC is a multi-protein complex that assembles at …

    mit Repository record

  3. Regulation of the localization of Lte1, a S. cerevisiae mitotic exit activator

    Seshan, AnupamaMassachusetts Institute of Technology2005

    … mitosis is initiated by the action of mitotic cyclins complexed with the cyclin dependent kinase (CDK). Once the chromosomes have been successfully segregated, the exit from mitosis ensues. In order for cells to exit from mitosis, mitotic CDKs must be inactivated. The inactivation of mitotic …

    mit Repository record

  4. Regulation of Morphogenetic Events in Saccharomyces cerevisiae

    Lai, Hung-Hsueh2018

    … to enter the cell cycle by activation of G1 cyclin/cyclin-dependent kinase (CDK) complexes, the polarity regulator Cdc42 becomes concentrated at the presumptive bud site, actin cables are oriented towards that site, and septin filaments assemble into a ring around the polarity site. Several …

    duke Repository record

  5. The Mitotic Exit Network detects spindle position and anaphase entry

    Campbell, Ian Winsten.Massachusetts Institute of Technology2019

    … the MEN is restricted to anaphase by inhibitory cyclin-dependent kinase (Cdk) phosphorylation of the MEN kinase cascade. During anaphase onset, Cdk activity decreases; creating a temporal signal that releases the MEN from inhibition. This temporal signal prevents MEN activation should the nucleus …

    mit Repository record

  6. Regulation of the Anaphase-Promoting Complex Examined at the Single Cell Level

    Ondracka, Andrej

    … cycle transitions are driven by oscillations of cyclin-cyclin dependent kinase (CDK) activity and associated cyclin degradation, mediated by ubiquitylation by the anaphase-promoting complex (APC). In this work, I analyzed the regulation of the APC by its activator Cdh1 in budding yeast in single …

    rockefeller Repository record

  7. Cell cycle control governing built-in asymmetry underlying the spindle pole body duplication cycle in Saccharomyces cerevisiae

    Peng, QiuranUniversity of Cambridge2022

    … of the mitotic spindle with an invariant age-dependent pattern of centrosome inheritance. Self- renewal supports tissue homeostasis by providing, in a balanced manner, one daughter cell retaining stemness and another daughter cell set to differentiate. Such balance is central to avoid …

    cambridge Repository record

  8. Phosphorylation of the replicative helicase by the S-phase kinase, Dbf4-Cdc7, at origins of replication in Saccharomyces cerevisiae

    Francis, Laura IleanaMassachusetts Institute of Technology2008

    … Complex (pre-IC) and this event requires two kinases, Cyclin Dependent Kinase (CDK) and Dbf4Dependent Kinase, Dbf4-Cdc7 (DDK). These events lead to activation of the Mcm2-7 helicase and recruitment of DNA synthesis machinery The S-phase kinase, DDK, phosphorylates the Mcm2-7 helicase, and is …

    mit Repository record

  9. The Role of Sphingosine Kinase 2 in Cell Growth and Apoptosis

    Sankala, Heidi M.2014

    Two isoforms of sphingosine kinase (SphK) catalyze the formation of sphingosine-1-phosphate (SIP). Whereas, SphKl stimulates cell growth and survival, it was found that when overexpressed in mouse NIH 3T3 fibroblasts SphK2 enhances caspase-dependent apoptosis in response to serum deprivation, …

    vcu Repository record

  10. Modulation of immune responses by human paraininfluenza virus

    Noone, CariosaDublin City University2007

    … of T cell proliferation. Inhibition was contact dependent and reliant on the absence of IL-2. Follow on studies demonstrated that T cell proliferation control was due to CD56+ natural killer (NK) cells. Of interest, the regulation was not exerted by NK cytotoxicity but by partial arrest of cell …

    dcu Repository record

  11. Covalent modification and intrinsic disorder in the stability of the proneural protein Neurogenin 2

    McDowell, Gary StevenUniversity of Cambridge2011

    … in mammalian cell lines, resulting in cell cycle-dependent regulation of stability. I will then discuss whether phosphorylation, a regulator of xNgn2 activity, also affects xNgn2 stability. I will provide evidence of cell cycle-dependent phosphorylation of cyclin dependent kinase (cdk) consensus …

    cambridge Repository record

  12. Increasing IFN-[gamma] productivity in CHO cells through CDK inhibition

    McClain, David AlanMassachusetts Institute of Technology2010

    … promise. Through the use of siRNA and chemical cyclin dependent kinase (CDK) inhibitors, we have developed new methods to improve and better understand recombinant protein production during growth arrest. In this study, we have shown that the specific inhibition of the CDK2-CcnE complex through …

    mit Repository record

  13. Determination Of The Essential Functions Of A Conserved Cyclin, Cyclin Y, In Drosophila

    Liu, Dongmei2010

    … encodes a member of a highly conserved family of cyclins, the Y type cyclins, which have not been functionally characterized in any organism. Here I report the generation and phenotypic characterization of a null mutant of <i>CG14939</i>, which we rename <i>Cyclin Y</i> (<i>CycY</i>). I show that …

    wayne-thes Repository record

  14. Peak Mitotic Cyclin Permits Mitotic Exit

    Drapkin, Benjamin

    … mitosis, and cytokinesis are all regulated by Cyclin-dependent kinase (Cdk). Cyclin/Cdk complexes promote replication origin firing and mitotic entry, and conversely, inhibit pre-replication origin loading and exit from mitosis. Cyclin synthesis and degradation, Cdk phosphorylation and Cdk …

    rockefeller Repository record

  15. Mechanisms preventing DNA replication between Meiosis I and Meiosis II

    Phizicky, David V. (David Vincent)Massachusetts Institute of Technology2018

    … segregation are regulated by oscillations of cyclin-dependent kinase (CDK) activity. Both events initiate during G1 due to the associated low CDK-activity state, and both events are completed later in the cell cycle due to increased CDK activity. During meiosis, uncoupling replication and …

    mit Repository record

  16. Controls Over S-Phase And Over Nuclear Synchrony

    Kiang, Lee Maxine

    … microarray analysis. Depletion of the mitotic cyclin induces periodic S-phases correlated with G1/S gene expression, cell volume doubling, and uses mostly mitotic S-phase origins to replicate the genome evenly. We conclude that cyclin dependent kinase (CDK) inhibits re-initiation of a mostly …

    rockefeller Repository record

  17. Mechanism of APC/C activation and substrate specificity in mitosis

    Zhang, SuyangUniversity of Cambridge2018

    … hyper-phosphorylation of APC/C subunits by cyclin-dependent kinase (Cdk) and polo kinase. The aim of the first part of this thesis was to understand how mitotic phosphorylation regulates APC/C activity. Using cryo-electron microscopy and biochemical analysis, we found that an auto-inhibitory …

    cambridge Repository record

  18. Defining Determinants of Primary Drug Resistance in Precision Cancer Therapies

    Ang, Hazel Xiaohui2021

    … drug screen, we discovered that inhibition of cyclin-dependent kinase (CDK) 12 dramatically sensitizes diverse models of TNBC to EGFR blockade. Instead of functioning through CDK12’s well-established transcriptional roles, this combination therapy drives cell death through the 4E-BP1-dependent …

    duke Repository record

  19. The nature of cachexia in patients with heart failure and stable coronary artery disease

    McEntegart, Margaret B.University of Glasgow2007

    … (IL-18) and the cell cycle inhibitors (cyclin dependent kinase (CDK) inhibitors) p21, p27 and p57. We found that the HF-cachexia group had significantly lower body mass index (BMI) and percentage body fat than all the other subject groups. In contrast, there was no significant reduction …

    glasgow Repository record

  20. Characterization of the specificity and functions of the protein phosphatase Cdc14

    Eissler, Christie

    … at multiple sites, often controlled by multiple kinases and phosphatases. Multisite phosphorylation can differentially affect the functional and regulatory cellular outcomes. For example, dephosphorylation of a protein at a particular site may inhibit nuclear localization of a protein while …

    purdue-thes Repository record

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