Global ETD Search
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Showing 1 to 9 of 9 for “"cyclin E/Cdk2"”.
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Mechanisms of cell cycle remodeling at the MBT during the development of Xenopus laevis embryos
… upon the degradation of maternally supplied cyclin E, which is the regulatory partner of the cyclin dependent kinase, Cdk2. To study the program that drives cyclin E degradation and cell cycle remodeling at the MBT, embryos were treated with two cell cycle inhibitors, GST-D34Xic1 and XChk1. …
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Funktion und Regulation von D- und E-Typ-Cyclin-Cdk-Komplexen während der Entwicklung von Drosophila
… durchlaufen wird. Die Aktivität von Cyclin E-Cdk(Cyclin-dependent kinase)2-Proteinkomplexen ist essentiell für den Eintritt in die S-Phase. Umgekehrt erfordert der Austritt aus der Zellproliferation zum korrekten Zeitpunkt in der Entwicklung die Inaktivierung von Cyclin …
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The Dynamics of the Unreplicated DNA Checkpoint in Xenopus laevis Embryos and Extracts
… pathways cause cell cycle arrest by inhibiting cyclin-dependent kinases (Cdks). In Xenopus laevis, early embryonic development consists of twelve rapid cleavage cycles between DNA replication (S) and mitosis (M) without checkpoints or gap phases. However, checkpoints are engaged in Xenopus once …
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Lmw-E Mediates Mammary Tumorigenesis By Deregulating Acinar Morphogenesis & Generating Cancer Stem Cells
<p>Cyclin E is the regulatory subunit of the cyclin E/CDK2 complex that</p> <p>mediates the G1-S phase transition. N-terminal cleavage of cyclin E by elastase in</p> <p>breast cancer generates two low molecular weight (LMW) isoforms that exhibit both</p> <p>enhanced kinase activity and resistance …
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Regulation of Substrate Degradation and Cancer Metabolism by the Fbw7 Ubiquitin Ligase
… of Fbw7 inactivation in colorectal cancers. Cyclin E-CDK2 is an important regulator of the G1/S transition in the cell cycle, and cyclin E is also an Fbw7 substrate. Phosphorylation of cyclin E at serine 384 (S384) is the critical switch that enables high-affinity binding of Fbw7. …
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Prolyl Isomerase Pin1 Is a Conditional Tumor Suppressor
… and degradation by the 26 S proteasome. Since cyclin E is another oncoprotein regulated by SCF<sup>Cdc4</sup>, we hypothesized that Pin1 may also bind to and facilitate cyclin E turnover. Here we show that Pin1 binds to the cyclin E-Cdk2 complex in a manner that requires Ser384 of cyclin E, …
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Funktionelle Charakterisierung der humanen Polo-Kinase Plk2/Snk im Zell- und Centrosomenzyklus
… von Proteinkinasen beschrieben, die neben den Cyclin-abhängigen Kinasen eine wichtige Rolle bei der Regulation des Zellzyklus spielen. Die funktionelle Charakterisierung dieser Proteine trägt entscheidend dazu bei, die komplexe Regulation des Zellzyklus sowie die Entstehung von Krebs zu …
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Impact of anti-viral immunity on neural stem/progenitor cell activity and implications for CNS development
… with decreases in the G1–phase specific cyclin E/CDK2 proteins and in pRb phosphorylation at serine 795 (S795). Together, these results indicate that the NSPC cell cycle was restricted in the late G1-phase. In STAT1-deficient (STAT1-KO) NSPCs, the effects of IFN on NSPC proliferation were …
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Molecular Mechanisms of Growth Inhibition Mediated by Retinoic Acid in Human Pancreatic Cancer Cells
… cycle, as well as in cellular concentrations of cyclins and their associated cyclin-dependent kinase (CDK) sub-units and CDK inhibitors (CDKI) such as p21, p27 and p16. Previously published studies have shown minimal effects of natural retinoids in inducing such changes in pancreatic cancer cell …