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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"cyclin E"”.
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Cytoplasmic Cyclin E Mediates Resistance to Aromatase Inhibitors In Breast Cancer
… of such resistance is not completely understood. Cyclin E is deregulated in breast cancer through generation of low molecular weight isoforms that renders patients to a poor survival. Herein, we show that HR+ patients with LMW-E expressing tumors show diminished early response to neo-adjuvant AIs …
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The Role of Cyclin E In Pkc Iota-Driven Early Ovarian Tumorigenesis
… in ovarian cancer, PI3K, PKCiota, and cyclin E, all of which have been shown to lead to a poor prognosis and decreased survival, converge into a single pathway that could potentially be targeted therapeutically.</p> <p>Because of the ability of either PKCiota or cyclin E overexpression …
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Atp-Citrate Lyase Links Cyclin E to Cellular Metabolism In Breast Cancer
<p>Cyclin E is altered or overexpressed in approximately one-third of tumors from patients with invasive breast cancer and is a powerful independent predictor for survival in women with stage I-III breast cancer. Full-length cyclin E (EL) is post-translationally cleaved into two …
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Low Molecular Weight Cyclin E Deregulates Dna Replication and Damage Repair to Promote Genomic Instability In Breast Cancer
<p>Low molecular weight cyclin E (LMW-E) are oncogenic forms of cyclin E that are post translationally generated by neutrophil elastase (NE) mediated cleavage of the 50 KDa full-length cyclin E1 (FL-cycE, encoded by <em>CCNE1</em>gene). The resultant N-terminus deleted (40 amino acids) form of …
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A study to investigate the role of P27 and Cyclin E immunoexpression as a prognostic factor in early breast carcinoma
Cyclin E and p27 expression is easy to assess in human tissues by standard immunohistochemical techniques. Immunohistochemistry is cost effective, relatively easy to perform and will play more of a role in the future management of cancer. To investigate the role of p27 and cyclin E immunoexpression …
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Mechanisms of cell cycle remodeling at the MBT during the development of Xenopus laevis embryos
… upon the degradation of maternally supplied cyclin E, which is the regulatory partner of the cyclin dependent kinase, Cdk2. To study the program that drives cyclin E degradation and cell cycle remodeling at the MBT, embryos were treated with two cell cycle inhibitors, GST-D34Xic1 and XChk1. …
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Cell cycle perspectives on breast cancer cell behaviour
… focusing on the cell cycle regulatory proteins cyclin E and cyclin D1. By expressing cyclin E in a breast cancer cell line we obtained experimental results indicating that increased proliferative activity obstructed migratory and invasive capacity. When validating these results in a large set of …
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Identification of a novel role for Eb1 in the regulation of cell growth and G1-S phase progression in Drosophila / by Deborah Coates.
… Drosophila Eb1, dEb1, which was identified in a cyclin E genetic screen. A dominant modifier screen was undertaken to identify novel regulators of cyclin E, and cell cycle progression using a hypomorphic allele of cyclin E. One suppressor from this screen, Su(DmcycEjp)2.5, was identified as a …
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Regulation of Substrate Degradation and Cancer Metabolism by the Fbw7 Ubiquitin Ligase
… of Fbw7 inactivation in colorectal cancers. Cyclin E-CDK2 is an important regulator of the G1/S transition in the cell cycle, and cyclin E is also an Fbw7 substrate. Phosphorylation of cyclin E at serine 384 (S384) is the critical switch that enables high-affinity binding of Fbw7. …
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Funktion und Regulation von D- und E-Typ-Cyclin-Cdk-Komplexen während der Entwicklung von Drosophila
… durchlaufen wird. Die Aktivität von Cyclin E-Cdk(Cyclin-dependent kinase)2-Proteinkomplexen ist essentiell für den Eintritt in die S-Phase. Umgekehrt erfordert der Austritt aus der Zellproliferation zum korrekten Zeitpunkt in der Entwicklung die Inaktivierung von Cyclin …
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Lmw-E Mediates Mammary Tumorigenesis By Deregulating Acinar Morphogenesis & Generating Cancer Stem Cells
<p>Cyclin E is the regulatory subunit of the cyclin E/CDK2 complex that</p> <p>mediates the G1-S phase transition. N-terminal cleavage of cyclin E by elastase in</p> <p>breast cancer generates two low molecular weight (LMW) isoforms that exhibit both</p> <p>enhanced kinase activity and resistance …
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Prolyl Isomerase Pin1 Is a Conditional Tumor Suppressor
… and degradation by the 26 S proteasome. Since cyclin E is another oncoprotein regulated by SCF<sup>Cdc4</sup>, we hypothesized that Pin1 may also bind to and facilitate cyclin E turnover. Here we show that Pin1 binds to the cyclin E-Cdk2 complex in a manner that requires Ser384 of cyclin E, …
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Analysis of cyclin-CDK mediated regulation of the G1/S transition in post quiescent murine fibroblasts
… be identified. Here we investigate the roles of cyclin E and cyclin A in the G1 to S-phase transition and reconstitute initiation of DNA replication in cyclin depleted nuclei using an in vitro DNA replication system. Using a murine 3T3 fibroblast model, chemical and genetic inhibition of CDK …
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Molecular cell cycle mechanisms of human prostate crcinoma insensitivity to TGF-β?
… association of p21WAF1/Cip1/Sdi1 with the Cdk2/cyclin E complex in both normal and prostate tumor cells. However, there was no increase in the association of p15INK4B nor p27K1P1 with the Cdk/cyclin complexes. In normal cells, the increase in the association of p21WAF1/Cip1/Sdi1 with the …
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The Novel Upstream Regulator of Fbxw7
… that targets numerous oncoproteins such as Cyclin E, c-Myc, c-Jun and MCL1. The deregulation of these proteins often leads to the proliferation of cancer cells. Thus, intracellular stability and functional activity of FBXW7 is critical for regulating cancer. However, there is a gap of …
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Anti-cancer Functions and Mechanisms of a pRb2/p130 Peptide Fragment
… able to inhibit the kinase activities of Cdk2/Cyclin E/A complexes. In vitro kinase assays showed the inhibition occurred in a dose-dependent manner. The half maximal inhibition concentration of the Spa310 in the kinase assay was 1.67mM. In addition, it has been shown that Spa310 peptide is …
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Oesophageal squamous cell carcinogenesis : a study of cell cycle regulatory proteins by immunohistochemistry
… - clone D0-7), p2l (Novocastro - clone 4Dl0), cyclin DI (Dako - clone DCS-6) and cyclin E (Novocastro - clone 13A3). Expression was interpreted as positive if 10% or more of the tumour cell population stained. Expression was also stratified into three levels (1, 2 and 3) depending on the …
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The histopathology and immunohistochemical expression of cell cycle regulators and mismatch repair gene proteins in colorectal carcinoma : a comparative study
… the cell cycle regulators (p21, p27, p53, c-myc, cyclin D1 and cyclin E) and MMP-7 in each cohort. To compare the immunoexpression of each marker between cohort s. To correlate the immunoexpression of each marker with tumour type, stage and grade. Materials and methods: In total, 17 mutation …
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Ezh2 T416 Phosphorylation Enhances Breast Cancer Tumorigenesis
… yet to be elucidated. Phosphorylation of EZH2 by cyclin dependent kinases (CDK) has been reported to control EZH2 epigenetic function and thus consequently control cancer cell proliferation, invasion, and stem cell differentiation. Our group has established that EZH2 and cyclin E, the enzymatic …
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The Dynamics of the Unreplicated DNA Checkpoint in Xenopus laevis Embryos and Extracts
… pathways cause cell cycle arrest by inhibiting cyclin-dependent kinases (Cdks). In Xenopus laevis, early embryonic development consists of twelve rapid cleavage cycles between DNA replication (S) and mitosis (M) without checkpoints or gap phases. However, checkpoints are engaged in Xenopus once …
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