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Showing 1 to 20 of 82 for “"cyclin D1"”.
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Effects of arsenic and UVB radiation on induction of cyclin D1 in human keratinocytes.
… We find that although both cause induction of cyclin D1, culturing cells with both co-mutagens does not lead to a potentiated effect. Evidence from other systems indicates that both arsenic and UVB affect promoter activity in various ways, including methylation. We undertook to examine the …
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THE ROLE OF DMP1 IN HUMAN BREAST CANCER PROGNOSIS AND CYCLIN D1-INDUCED BREAST CANCER
… pathway. Dmp1 physically interacts with cyclin D1 that is frequently overexpressed in breast cancer. Cyclin D1 can either increase or decrease the transcriptional activity of Dmp1 depending the molecular contexts of the targeted genes. Although loss of Dmp1 significantly accelerated …
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Preventing Thymus Involution In K5.Cyclin D1 Transgenic Mice Sustains The Naïve T Cell Compartment With Age
… in mice expressing a keratin 5 promoter-driven Cyclin D1 (K5.D1) transgene in thymic epithelial cells (TECs). Thymopoiesis occurs normally in K5.D1 transgenic thymi and sustains T cell output to prevent the age-associated decline of naïve T cells in the periphery. We find that K5.D1 recent …
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Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer
… The markers examined were associated with CCND1 amplification (Chk1 and β-arrestin1), which has previously been linked to a potential adverse effect of tamoxifen, or with epithelial-mesenchymal transition (Snail), a biological process crucial for the development of metastasis. …
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CYCLIN D1 AND WILMS TUMOR TRANSCRIPTION FACTOR-1 (WT1): POTENTIAL DIAGNOSTIC AND THERAPEUTIC MARKERS IN SMALL ROUND BLUE CELL TUMORS OF CHILDHOOD
… in cell growth and development. The protein Cyclin D1 (CD1), encoded by the CCND1 gene, belongs to the highly conserved cyclin family, whose members function as regulators of CDKs (cyclin-dependent kinase) through-out the cell cycle. CD1 serves as a key sensor and integrator of extracellular …
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A study of the relationship of the internal endocrine environment to the p53 network, cyclin D1 and replication licensing proteins in breast cancer
… of various tumour markers (p53, mcm2 and cyclin D1) with change in internal endocrine environment in patients with primary breast cancer and to study the expression and prognostic association of cyclin D1 and replication licensing proteins (mcm2 and geminin) in invasive breast cancer. …
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Role of cyclin D1 as an estrogen receptor cofactor and the influence of hypoxia on estrogen receptor regulation, with focus on prognositic and treatment predictive features in breast cancer
… been correlated to loss of ER in breast tumors. Cyclin D1, initially described as a cell cycle regulator, might also function as a cofactor to ER inducing ligand independent activation of the receptor. We therefore determined the relation between ER, cyclin D1 and HIF-1 expression in primary …
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Cell cycle perspectives on breast cancer cell behaviour
… focusing on the cell cycle regulatory proteins cyclin E and cyclin D1. By expressing cyclin E in a breast cancer cell line we obtained experimental results indicating that increased proliferative activity obstructed migratory and invasive capacity. When validating these results in a large set of …
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Unterschiedliche Aktivierung von Signalwegen zur Zellproliferation in mesenchymalen Tumoren des Gastrointestinaltrakts
… Tumoren mehr in GIST exprimiert. Während die Cyclin-D1-Expression der GIST höher war, wurden die höchsten E2F1- und Cyclin-B1-Expressionen bei den Leiomyosarkomen gefunden.SCHLUSSFOLGERUNGEN:Im Vergleich zu Leiomyomen weisen Leiomyosarkome PDGFRA-Expression auf. Für GIST kann eine sequentielle …
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Investigating Prostaglandin E2 activation of the p38 pathway of oesophageal squamous cell carcinoma
… transcription and expression of proliferative (Cyclin D1) and inflammatory (IL-6) mediators in a human epithelial oesophageal cell line (Het1a). Methods: The proliferation potential of PGE2 via p38 was assessed by MTT assay on Het1a. The effect of H2O2 treatments was also assessed as a positive …
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Investigating the Involvement of RNA-Binding Protein ZFP36L1 in Breast Cancer Progression
… of cell-cycle-related genes, including cyclin D1, CDK6 and tumour suppressor p53. Notably, cyclin D1 and CDK6 transcripts contain ARE sequences in the 3’ UTR, suggesting that they could be the direct targets of ZFP36L1 in MCF-7 cells. Similarly, we observed an upregulation of several …
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Serial Analysis of Gene Expression of Rat Liver Regeneration by Oval Hepatic Stem Cells
… Genen fanden sich Zellzyklusgene wie CDC42 und Cyclin D1; Zytoskelett-assotiierte Proteine wie Stathmin 1 und E-Tropomodulin; Signaltransduktion triggernde Gene wie CDC151 und Lipopolysaccharid bindendes Protein; Transportergene wie Na+/Pi-Kotransporter 4, Phosphatidylcholin Transferprotein und …
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The N-terminal Domain of the Y-box Binding Protein YB-1 Plays a Major Role in Cell Proliferation and Apoptosis
… in levels of cell cycle specific genes like the cyclin dependent kinase inhibitor - p21.</p> <p> The current study is based on the hypothesis that the defects seen in the heterozygous mutant DT-40 cells were due to a dominant negative effect of the potential YB-1 N-terminal truncated protein. The …
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Differenzielle Regulation und prognostische Bedeutung von zellzyklusassoziierten Regulatoren der G1- und G2-Phase in Abhängigkeit von der anatomischen Lokalisation in Gastrointestinalen Stromatumoren (GIST)
… von den G1-Phase-Proteinen E2F1 und Cyclin D1, sowie von den G2-Phase-Proteinen Cyclin A2 und Cyclin B1 und dem Transkriptionsfaktor Myc wurden in Abhängigkeit von den klinisch-pathologischen Parametern Lokalisation, Morphologie, Tumorgröße, Mitosenanzahl und Mutationsstatus …
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Molekulargenetische Untersuchung der chromosomalen Translokation t(11;14)(q13;q32) im Marginalzonen-B-Zell-Lymphom der Milz
… welche zu einem BCL1-Rearrangement und Cyclin D1 Überexpression führt, gehört nicht zu den molekulargenetisch nachweisbaren Merkmalen des Marginalzonen-B-Zell-Lymphoms, sondern ist stark mit dem Mantelzell-Lymphom assoziiert.
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Altered Responses to Endoplasmic Reticulum Stress In Pancreatic Cancer
… to be due to an impaired ability to downregulate cyclin D1, a key gatekeeper of the G1/S checkpoint. Abrogation of cyclin D1 repression was mediated through a slow induction of phosphorylation of eIF2α, a critical mediator of translational attenuation in response to ER stress.</p> <p> <p> In …
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Studies of the anti-cancer potential of flavonoids in Human Nasopharyngeal carcinoma cells
… activity, thus preventing the expression of cyclin E. In addition, quercetin induced apoptosis by up-regulating the expression of Bad and Bax in HK1 and CNE2 cells. In the second part of our study, luteolin was found to inhibit cell cycle progression at G1 phase via enhanced protein …
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The direct effects of estradiol and several xenoestrogens on cell numbers of early- vs. late-stage prostate cancer cells
… and levels of cell cycle proteins. Regulation of cyclin D1 played a major role in blocking cell proliferation, but extracellular signal-regulated kinase (ERK) causing ROS generation, phosphorylation of p38, apoptosis, and phosphorylation of p16INK4A also contributed. Our rapid effects suggested …
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Biomarkers of Progression from Barrett's Oesophagus to Oesophageal Adenocarcinoma
… BO. We have noted a mirroring action of p53 and cyclin D1. In addition, aberrant expression of p53 and p16, along with strong expression of cyclin D1 may indicate the presence of cancer. We found the accuracy of a model that involved the use of p53, p16 and cyclin D1 in the<br/>diagnosis …
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