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Showing 1 to 20 of 22 for “"cyclin D"”.
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Funktion und Regulation von D- und E-Typ-Cyclin-Cdk-Komplexen während der Entwicklung von Drosophila
… durchlaufen wird. Die Aktivität von Cyclin E-Cdk(Cyclin-dependent kinase)2-Proteinkomplexen ist essentiell für den Eintritt in die S-Phase. Umgekehrt erfordert der Austritt aus der Zellproliferation zum korrekten Zeitpunkt in der Entwicklung die Inaktivierung von Cyclin …
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Design of Non-ATP Competitive and Cell Cycle Specific CDK Inhibitors Targeting Cyclin Binding Groove
<p>CDK2/cyclin A and CDK4/cyclin D1 are validated targets for cancer drug discovery with ATP competitive compounds being the most common inhibitors. However, issues arising from the selectivity of current inhibitors have prevented clinical validation of these important targets. To generate cell …
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Role of MDM2 In Cell Growth Regulation
… overexpression does not prevent expression of cyclin D, cyclin D-CDK mediated phosphorylation of Rb or cyclin E in normal, immortal or tumor-derived cells. However, MDM2 down-regulates cyclin A expression specifically in normal cells, which is associated with G1 arrest. The domain of MDM2 …
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Molecular analysis of the role of Caspase-8 during liver regeneration and tumorigenesis
… which directly contributes to gene activation of Cyclin D via NF-kappaB, c-Jun/ AP-1 and E2F1. The aim of the present study was to investigate the consequences of Caspase-8 deletion for TNF signaling during liver regeneration and termination as well as the role of Caspase-8 for initiation and …
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Androgen receptor-mediated growth suppression and apoptosis of human prostate epithelial cells
… suppression is dependent on the inhibition of cyclin D-CDK4/6 complexes through transcriptional repression of the CDK4 and CDK6 genes and transcriptional activation of the CDKN1A/p21 gene. Further, AR inhibits cyclin D2 transcription and destabilizes cyclin D1 mRNA in HPr-1AR cells. The …
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The effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on oxidative and hypoxic stress in the vascular endothelium
… of Bax and cell cycle regulator protein Cyclin D. Acute withdrawal of statins reverses the protective effects on EC survival by promoting apoptosis and inhibiting the proliferative activity.
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Specific, Reversible Cytostatic Protection of Normal Cells Against Negative Effects of Chemotherapy
… in the G1 phase cell cycle proteins cdk4 and cyclin D, as well as the inhibitor p27. Phosphorylated Rb was also elevated in the arrested cells. These results are a departure from cell culture studies, in which inhibition of G1 phase cyclin dependent kinases led to hyposphosphorylation of Rb. …
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TRANSCRIPTIONAL NETWORKS VARIATIONS DURING CELL CYCLE PROGRESSION IN HUMAN EMBRYONIC STEM CELLS
… More precisely, the cell cycle regulator Cyclin D appears to control the transcriptional activity of Activin/Nodal signalling during progression of the cell cycle in human Embryonic Stem Cells (hESCs). As a consequence, hESCs can only differentiate into endoderm in the Early G1 phase when …
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Modulation of the Hippocampal Neurogenic Program by the Circadian Clock Machinery and the small GTPase, Rasd1/ Dexras1
… mediating cell-cycle inhibitors that targets the cyclin D/Cdk4-6 complex, and in turn disruptions in this system result in the abolishment of gating mechanisms. This study uncovers the interrelationship between the cell cycle and the circadian clock and emphasizes the importance of proper …
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Targeting Autophagy to Improve Efficacy of Cdk4/6 Inhibition In Breast Cancer
… tumorigenesis. The crucial role of the CDK4/6-Cyclin D pathway has led to the development and FDA approval (palbociclib, ribociclib) of CDK4/6 inhibitors for the treatment of advanced estrogen receptor positive breast cancer. However, three major clinical challenges remain: i) adverse events …
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Stability, folding and evolution of the tumour suppressor protein p16.
… a member of the INK4 family of inhibitors of the cyclin D-dependent kinases 4 and 6 in the pRb pathway of eukaryotic cell cycle. The 156-amino acid protein consists of four ankyrin (ANK) repeats. The ANK repeat is a ubiquitous 33-residue sequence motif that adopts a β-hairpin-helix-turn-helix …
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Anti-cancer Functions and Mechanisms of a pRb2/p130 Peptide Fragment
… able to inhibit the kinase activities of Cdk2/Cyclin E/A complexes. In vitro kinase assays showed the inhibition occurred in a dose-dependent manner. The half maximal inhibition concentration of the Spa310 in the kinase assay was 1.67mM. In addition, it has been shown that Spa310 peptide is …
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Genetic Characterization of Pediatric T-cell Acute Lymphoblastic Leukemia
… of a targeted deregulation of a member of the cyclin-encoding gene family in T-ALL. Cyclin D proteins are crucial to the cell cycle machinery and hence potential oncogenes. The second translocation cloned, t(X;7)(q22;q34), had not previously been reported in a neoplastic disorder. Breakpoint …
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Gene expression underlying ferret hair growth initiation induced by melatonin and modified by steroids
… ferret hair acidic keratin 8 (fHa8) and ferret cyclin D-interacting myb-like protein 1 (fDMP1). Both of these genes were expressed only in cortical cells in the keratogenous zone from mid-proanagen. fHa8 was expressed only in one side of the cortex, a feature has not previously been reported for …
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Ubiquitination of proteins involved in metabolism and immunomodulatory drug sensitivity in lymphocytes
… Cdk6 is activated through binding the D-type cyclins, and historically, a key role has been as a cell cycle regulatory kinase that inactivates G1 checkpoint proteins. More recently, wider roles for Cdk6 have been identified, including as an inhibitor of glycolysis. Notably, Cdk6 has …
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Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
… epidermis expressed decreased levels of cyclin D and E and increased levels of cyclin A and B1. EGFR-dependent activation of extracellular-signal regulated kinases (ERK1/2), p38 kinase and c-Jun NH2-terminal kinase (JNK) increased keratinocyte proliferation.|Ultraviolet irradiation (UV), …
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Repression of E2F-4 Mediated Transcription and Growth by Hypophosphorylated pRb2/p130 in Human Prostate Cancer Cells
… genes, which includes p107 and a number of cyclins (Figure 1). Upon entry into G1, the many phosphoacceptor sites of pRb2/p130 are progressively phosphorylated, disrupting the repressor complex, and allowing the transcription of downstream targets. pRb2/p130 is acted upon by the same early …
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Molecular aspects of the link between obesity, insulin resistance and breast cancer.
… decreased. Gene expression of cyclin D and cyclin E increased with insulin treatment, while apoptotic rate and cell cycle profile were also not affected. Cell proliferation increased by 115% after treatment with 100 ng/ml leptin. ERK1/2-phosphorylation however decreased, while …
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Investigating the functional significance of the upregulation of Cyclin D2 and p21 following Apc loss in vivo
… the importance of the upregulation of the Cyclin D/CDK4 complexes following Apc loss and their role in c-Myc dependent proliferation. Results from these studies showed that Cyclin D2 is required for efficient proliferation immediately following loss of Apc as well as for tumourigeneis in …
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