Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"cyclin A2"”.
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Mechanism of APC/C activation and substrate specificity in mitosis
… hyper-phosphorylation of APC/C subunits by cyclin-dependent kinase (Cdk) and polo kinase. The aim of the first part of this thesis was to understand how mitotic phosphorylation regulates APC/C activity. Using cryo-electron microscopy and biochemical analysis, we found that an auto-inhibitory …
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Differenzielle Regulation und prognostische Bedeutung von zellzyklusassoziierten Regulatoren der G1- und G2-Phase in Abhängigkeit von der anatomischen Lokalisation in Gastrointestinalen Stromatumoren (GIST)
… von den G1-Phase-Proteinen E2F1 und Cyclin D1, sowie von den G2-Phase-Proteinen Cyclin A2 und Cyclin B1 und dem Transkriptionsfaktor Myc wurden in Abhängigkeit von den klinisch-pathologischen Parametern Lokalisation, Morphologie, Tumorgröße, Mitosenanzahl und Mutationsstatus …
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Design of Non-ATP Competitive and Cell Cycle Specific CDK Inhibitors Targeting Cyclin Binding Groove
<p>CDK2/cyclin A and CDK4/cyclin D1 are validated targets for cancer drug discovery with ATP competitive compounds being the most common inhibitors. However, issues arising from the selectivity of current inhibitors have prevented clinical validation of these important targets. To generate cell …
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Analysis of cyclin-CDK mediated regulation of the G1/S transition in post quiescent murine fibroblasts
… be identified. Here we investigate the roles of cyclin E and cyclin A in the G1 to S-phase transition and reconstitute initiation of DNA replication in cyclin depleted nuclei using an in vitro DNA replication system. Using a murine 3T3 fibroblast model, chemical and genetic inhibition of CDK …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… pERK1/2 activity and upregulated S phase cyclin A2. I have also revealed that HERV-K Env overexpression is regulated by TEAD-mediated transcription both in Merlin-deficient schwannoma and grade I meningioma. Furthermore, I have successfully tested the FDA approved retroviral protease …