Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"cyclin/Cdks"”.
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Cell Cycle Control by Cyclin-CDKS in Chlamydomonas Reinhardtii
… and fungi in which the activities of various cyclin-dependent kinases (CDKs) and the anaphase promoting complex (APC) drive the events of the cell cycle at the appropriate time and in the appropriate order. While this model has been extremely useful for understanding cell division in these …
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Regulation of the Anaphase-Promoting Complex Examined at the Single Cell Level
… cycle transitions are driven by oscillations of cyclin-cyclin dependent kinase (CDK) activity and associated cyclin degradation, mediated by ubiquitylation by the anaphase-promoting complex (APC). In this work, I analyzed the regulation of the APC by its activator Cdh1 in budding yeast in single …
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Studies of the Kinetics of Cell Cycle Processes in S. Cerevisiae: The Molecular Basis of Start Irreversibility and Cyclin-Cdk Ordering of Mitotic Events
… central negative feedback oscillator comprising cyclin-CDK and its antagonist, APCCdc20. This oscillator is stabilized and tuned by positive feedback loops, and its frequency is modulated by checkpoint controls. Either by directly triggering events, or by entraining independent oscillators …
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Loss of Chk1 Function and Exogenous Expression of Cyclin A1/Cdk2 Results in Apoptosis after the MBT in Early Xenopus laevis Embryos
… the role of two cell cycle components, Chk1 and cyclin A1/Cdk2, during apoptosis was studied during early development of Xenopus embryos. Chk1 is a serine/threonine kinase that inhibits the activity of cyclin-dependent kinases (Cdks) in response to unreplicated DNA. In the pre-MBT embryo, Chk1 is …
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Molecular Mechanisms of Growth Inhibition Mediated by Retinoic Acid in Human Pancreatic Cancer Cells
… cycle, as well as in cellular concentrations of cyclins and their associated cyclin-dependent kinase (CDK) sub-units and CDK inhibitors (CDKI) such as p21, p27 and p16. Previously published studies have shown minimal effects of natural retinoids in inducing such changes in pancreatic cancer cell …
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B cell signalling in mechanisms of central and peripheral tolerance
… has now been implicated in the maintenance of cycling ERK activation observed in spontaneously proliferating WEHI-231 B cells. BCR signalling was found to reduce the levels of active Rap, hence providing a mechanism for the BCR-mediated uncoupling of the Ras-independent, MEK-dependent ERK …