Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"cyclic-di-GMP"”.
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Cyclic-di-GMP Signaling in the Borrelia Spirochetes
<p>Lyme disease is the most common tick-borne disease in North America, with approximately 35,000 cases reported to the Centers for Disease Control in 2008. The genome of its causative agent, Borrelia burgdorferi, encodes for a set of genes involved in the metabolism and regulatory activities of …
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Characterization of cyclic-di-GMP signaling with the Lyme spirochete, Borrelia burgdorferi
Lyme disease is a tick-borne infection caused by Borrelia burgdorferi, B. garinii, and B. afzelii. These spirochetes experience environmental fluctuations as they are passed between mammalian and Ixodes tick hosts throughout their enzootic cycle. Recent studies have suggested cyclic diguanylate …
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Characterization of cyclic di-GMP binding by the sole Borrelia burgdorferi and Borrelia hermsii PilZ domain-containing proteins
… burgdorferi and Borrelia hermsii cause Lyme disease and relapsing fever, respectively. These spirochetes are maintained in an enzootic cycle, involving tick vectors and mammalian hosts. Differential gene expression is central in their survival in various environmental conditions. C-di-GMP has …
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Cyclic di-GMP signalling and the regulation of virulence, biofilm formation and epiphytic fitness in the phytopathogen <i>Xanthomonas campestris</i>
… for its host plant is dependent on many different factors (Chan and Goodwin, 1999). A pivotal role is played by the second messenger cyclic di-GMP. C-di-GMP is essential for successful infection of the host not only by <i>Xcc</i> but also by many other pathogens. Roles for c-di-GMP …
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THE SUBTLE BIOFILM REGULATION IN ESCHERICHIA COLI: CSGD AND THE YDDV-DOS OPERON
… environment. The biofilm determinants studied in this thesis are all expressed in response to environmental conditions such as low temperature, low osmolarity and starvation, suggesting that E. coli bacteria switch to a biofilm mode of growth as part of their adaptation to the natural …
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Unifying the features that determine substrate preferences of nanoRNases
RNA polymers are synthesized, degraded, and modified through several varied cellular processes. The ability of cells to degrade and recycle their RNA products is a ubiquitous and essential function. Specific subsets of endo- and exoribonucleases catalyze the reactions that ultimately replenish the …
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Animal models for investigating coronavirus heterotypic immunity
… and, while usually mild, represent the 6th leading cause of viral pneumonia. Additionally, multiple zoonotic spillovers of CoVs have occurred in the last 25 years to cause severe pneumonia, most recently the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory …
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The Type IV Pilus Assembly ATPase PilB as a Regulator of Biofilm Formation and an Antivirulence Target
… appendages with a variety of functions including motility, surface attachment, and biofilm formation. In many species of bacteria a clear understanding of how the functions of T4P in lifestyle switching are regulated remains to be elucidated. Here, we focus on understanding the regulation of …
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Synthesis of Non-Natural Cyclic Di-Nucleotides for the Investigation of Bacterial Signaling Pathways
… the ability to communicate, albeit in more discreet, yet no less complex ways. Bacteria rely on an incredibly diverse signaling system of triggers and responses in order to survive and to thrive. While we perceive language with our eyes and ears, bacteria employ a system of small molecules …
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REGULATION AND EXPRESSION OF AMYLOID CURLI IN SALMONELLA INFECTION
… spent characterizing what could be seen with a rudimentary microscope. Today, knowledge of biofilms in vitro has grown substantially with modern technology; however, knowledge of biofilms in vivo is still lacking. By forming a biofilm, the bacterium increases its persistence and chances of …