Global ETD Search
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Showing 1 to 2 of 2 for “"cyclic tertiary-allylamine"”.
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Investigation of FAD Chemical Models to Study the Monoamine Oxidase Catalyzed Oxidation of Cyclic Tertiary-Allylamines
… oxidase (MAO) catalyzed oxidation of the cyclic tertiary allylamine 1-methyl-4-(2-methyl-1H-pyrrol-2-yl)-1,2,3,6-tetrahydropyridine (TMMP), which is a close analog of the parkinsonian-inducing designer drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MAO-B catalyzes the conversion …
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Synthesis and biological evaluation of novel MPTP analogs as potential monoamine oxidase B inhibitors
… and close structural analogs are the only known cyclic tertiary amines with good monoamine oxidase substrate properties. In addition to its substrate properties, MPTP is a weak mechanism-based inactivator of monoamine oxidase-B (MAO-B). In an attempt to exploit the special interactions between …