Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"cyclic strain"”.
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Assessment of the Cyclic Strain Approach for the Evaluation of Initial Liquefaction
… evaluation procedures include the stress-based, strain-based, and energybased based approaches. The existence of a volumetric threshold shear strain, γtv, under which there is no development of excess pore pressures, and the unique relationship between pore pressure ratio and cyclic shear strain, …
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The role of altered cyclic strain patterns on proliferation and apoptosis of vascular smooth muscle cells - implications for in-stent restenosis
… stent procedure dramatically alters the level of strains and stresses in the coronary artery and hence the mechanical environment of the SMC. We hypothesised that there exists a direct causal relationship between the level of strain and vascular SMC proliferation and apoptosis within the vessel …
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Mechanotransduction Modulates the Effect of Mechanical Forces (Fluid Shear Stress and Cyclic Strain) on Embryonic Stem Cell Differentiation Toward Vascular Endothelial Cells
… to beat, the vasculature starts to experience cyclic strain (CS) and associated stress in addition to shear stress. While cyclic strain has been shown to induce mESC and Flk-1<sup>+ </sup> cells differentiation into vascular smooth muscle cells, there have been no studies to elucidate the …
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Notch signaling pathway in human vascular smooth muscle cell differentiation
… pathology. It has been previously shown that cyclic strain decreases the proliferation of VSMC'S in vitr-u. Tnus, citaraci-erizauon of &e mechani~rils~ "~i ir~l i iirligi ~ b i fk~e~l i iai i~i -~ state of VSMC is of critical importance in determining the cell fate response of these cells to …
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Scleraxis-mediated regulation of tendon and ligament cell mechanobiology
… has been shown that Scx expression is induced by cyclic mechanical strain in tenocytes and is required for mechanically-induced stem cell tenogenesis. Moreover, Scx expression is increased in adult tendons following exercise. The studies described in this dissertation therefore focus on the …
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Endothelial cell impact on smooth muscle cell properties: role of hemodynamic forces
… blood as it drags against the endothelium, and cyclic strain, transmural pressure due to the pulsatile nature of blood flow. Both forces can profoundly modulate vascular endothelial metabolism and function and, within normal physiological ranges, typically impart an atheroprotective effect which …
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Molecular mechanisms of strain-stimulated intestinal epithelial cell differentiation and migration
… by peristalsis and villous motility. In vitro, cyclic strain promotes intestinal epithelial proliferation and induces an absorptive phenotype characterized by increased dipeptidyl dipeptidase (DPPIV) expression. Schlafen 3 is a novel gene recently associated with cellular differentiation. We …
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Cyclic stretch-mediated release of vascular endothelial growth factor by vascular smooth muscle cells : a role in improved vascular graft patency
… of VEGF in contractile cells subjected to cyclic stretch and the profound effects which cyclic stretch has been shown to have on the release of other cytokines by SMC, this study investigates the role which cyclic stretch might play in VEGF expression by SMC in a compliant environment. …
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Stress in a Microgravity Bioreactor
… as bone and muscle, require mechanical stress, strain, and mechanical loading to develop properly. Because of this, a device that can induce strain on cells while subjected to microgravity conditions is needed to further improve cellular research for space exploration. The constructed bioreactor …
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Functional properties of polyurethane based sealants blended with polymeric modifiers
… program in which the tensile strength and cyclic performance of the sealants was compared to that of existing two-component self-leveling sealant compounds currently available on the market. Results of these performance tests indicate that lignin filled elastomeric sealants, in most …
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Skeletal muscle biomechanics drives intramuscular transport of locally delivered drugs
… 0.45m/s, and 8.5m/s2, respectively, for imposing cyclic strain on soleus muscle samples. Total compliance of the series assembly from the motor to muscle mounting blocks was less then 0.0057 ± 0.002mm/N.
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An investigation into the polyethylene extrudates produced by simultaneous orientation and high temperature quenching
… HOPE extrudates was analysed by tensile testing, cyclic strain recovery, shrinkage testing, density measurements and annealing in air and liquid metal at 117°C. It was found that the level of draw-down and the temperature of the quenching medium had a profound effect upon the resultant properties …
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Cyclic Uniaxial Constitutive Model For Steel Reinforcement
… the steel reinforcement is subjected to cyclic strain histories which lead to inelastic response. In the case of rare, strong earthquakes, inelastic buckling and even rupture due to low-cycle fatigue can also occur. The understanding and characterization of the performance of RC …
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Effects of Voids on Delamination Behavior Under Static and Fatigue Mode I and Mode II
… lead to a decrease in modes I and II maximum cyclic strain energy release rates and fatigue life. Fractographic features allowed relations to be drawn between fracture surfaces and mechanical properties of the composite, and to investigate the differences in the fractographic features between …
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The role of death-associated protein kinase in endothelial apoptosis under fluid shear stress
… as flexible silicone membrane normally used for cyclic strain studies. We have shown a link between shear stress and DAPK expression and apoptosis in cells on membrane. Along with biochemical and molecular signals, the hemodynamic forces that the cells experience are also important regulators of …
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Modeling cycle and time dependent creep/relaxation effects on fatigue lives of notched members
Mechanical cyclic variations in mean stress and strain amplitude is a well-known occurrence for metals even at room temperature. Many fatigue analysis procedures ignore these variations. Fatigue analysis which included both time and cycle dependent mechanical material behavior for metals at room …
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EFFECTS OF LASER MACHINING ON STRUCTURE AND FATIGUE OF 316LVM BIOMEDICAL WIRES
… were evaluated in uniaxial tension, and in cyclic strain-controlled fatigue with the use of a flex tester operated to provide fully reversed bending fatigue. All the fatigue testing was conducted in air over a range of cyclic strains to determine both the high-cycle and low-cycle fatigue …
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Implementation of Physiologic Pressure Conditions in a Blood Vessel Mimic Bioreactor System
… Two important mechanical stimuli are cyclic strain and wall shear stress. Previous work sought to improve these factors within the BVM bioreactor and resulted in the implementation of pulsatile perfusion and increased fluid viscosity. These previous bioreactor design modifications …
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A patient specific total disc replacement to treat degenerative disc disease
… regenerative cell responses under physiological cyclic loads. Finite element (FE) modelling was used as a prescriptive rather than descriptive tool to guide the design of a scaffold-based TDR capable of matching physiological stiffness in compression, flexion/extension, lateral bending, and axial …
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