Global ETD Search
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Showing 1 to 2 of 2 for “"cyclic oligoadenylate"”.
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Identification and Characterization of Novel CRISPR-Cas Immune Effectors
… to type III CRISPR, is the synthesis of cyclic oligoadenylate molecules (cOAs) of various sizes from ATP substrates by the catalytic activity of the palm domain. cOAs go on to activate additional accessory immune effectors encoded within type III CRISPR loci that provide immunity …
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Accessory Nucleases Provide Robust Antiparasite Immunity for Type III CRISPR-Cas Systems
… that the Palm domain of Cas10 can synthesise cyclic oligoadenylate second messengers (cA). cA can activate Csm6 by binding to the latter's CARF domain. In this work, I first elucidate and illuminate the role and mechanism of action of Csm6 during anti-plasmid immunity in staphylococci. I show …