Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"cyclic nucleotide"”.
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Structural Insights into Ion Selectivity and Calcium Blockage in Cyclic Nucleotide Gated Channels
Cyclic nucleotides-gated (CNG) channels play an essential role in the visual and olfactory sensory systems and are ubiquitously expressed in a variety of neuronal and non neuronal cells. Details of their underlying ion selectivity properties are still not fully understood and a matter of debate in …
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Phosphodiesterase 1 (PDE1) at the Crossroads of Calcium and Cyclic Nucleotide Signaling in Diabetic Nephropathy
… of DKD. While renoprotection is mediated by cyclic nucleotides (cAMP and cGMP), phosphodiesterases (PDEs) lead to cyclic nucleotide degradation. Our investigation focused on the role of calcium/calmodulin activated PDE1 in DKD. Three isoforms of PDE1 are differentially expressed in vascular …
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The Role of Phosphodiesterases in Cyclic Nucleotide Compartmentation Across Different Pathways in the Adult Rat Ventricular Myocyte
… mediated signalling pathways converge on cyclic nucleotide production. These second messengers act to achieve changes in cellular function. Despite this, each signalling molecule and receptor can achieve distinct sub-cellular effects. This has led to the theory of cyclic nucleotide …
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The Role of Arabidopsis thaliana Cyclic Nucleotide-Gated Channels 2, 6, and 19 in Extracellular ATP Signalling
… membrane (PM) eATP receptors DOES NOT RESPOND TO NUCLEOTIDES1 (DORN1/P2K1) and DORN2/P2K2 have been identified in Arabidopsis thaliana in the past decade. The perception of eATP leads to downstream changes of secondary messengers, including cytosolic free calcium ([Ca2+]cyt) increase, reactive …
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Measurement of cyclic nucleotides in human sperm: experimental and clinical application
… available to assess essential second messengers. Cyclic nucleotides (cAMP and cGMP) play a crucial role as signalling molecules for capacitation, motility, and acrosome reaction in mammalian sperm. Given their importance in motility and fertilising ability, defective nucleotide function could be a …
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Testing the Role of Cyclic Nucleotides in Regulating Ion Channels Essential to Pollen Fertility
It is unknown if plant cyclic nucleotide gated channels (CNGCs) are activated by cyclic nucleotide monophosphates (cNMPs, e.g. cAMP or cGMP), or even if cNMPs are present at physiologically significant levels in plants. cNMP presence in growing A.thaliana pollen tubes was visualized using …
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Immunohistochemistry for studying cyclic nucleotides in the central nervous system, with particular reference to guanosine 3',5'-monophosphate
… with the aim of histochemically localizing cyclic AMP and cyclic GMP in the C.N.S., and determining the cellular sites where biochemical changes in tissue levels occur. Initial experiments revealed that the inmunoglobulin fraction of non -immune sera bound non -specifically to C.N.S. tissue, …
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Manipulation of second messengers by ectopic expression of receptors in transgenic Drosophila
… selective manipulation of the second messengers cyclic GMP (cGMP), cyclic AMP (cAMP) and calcium (Ca2+) in the renal (Malpighian) tubule of the genetic model organism, Drosophila melanogaster. The importance of the second messengers cGMP, cAMP and Ca2+ in control of fluid transport makes the …
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MRP4-Dependent Regulation of Fibroblast Migration
<p>Roles of cyclic nucleotides and cyclic nucleotide-dependent signaling molecules in regulating several signaling pathways including cell migration have long been known. However, the new and revolutionary concept is that it is not just the absence or presence of cyclic nucleotides, but a highly …
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Characterization of C-Gmp Dependent Kinases Within the Circadian Molecular Clockworks: Structural, Phylogenetic, and Functional Analyses
… analysis of the protein rather than the specific cyclic nucleotide activator. Phylogenetic analysis of the entire cGK family demonstrates that the gene duplication that lead to the Prkg1 and Prkg2 genes found within extant vertebrate metazoans actually occurred before the Arthropoda split from the …
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The expression and purification of the regulatory domain of PKG1 alpha
Cyclic guanosine dependent protein kinases play key roles in many functions throughout the body. Three different types of these kinases exist in humans: type one alpha, one beta, and two. The different kinases exist in different locations within the body and also have different substrates that they …
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Effects of progesterone on newly synthesized proteins in the ventromedial hypothalamus of the estrogen-primed female rat
… to act, progesterone may work by affecting cyclic nucleotide activity.
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Studies on the Mechanism of Action of Calmodulin
… interactions of CaM with Ca('2+)+CaM sensitive cyclic nucleotide phosphodiesterase (PDE) and with troponin I. Because CaM has been found to behave in a similar manner in most, if not all, of the systems in which it is a participant, information gathered with these systems may be of general …
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The role of hyperpolarization-activated non-selective cation current in amygdala excitability and serotonin mediated effects.
The hyperpolarization-activated, cyclic nucleotide-dependent non-selective cationic (HCN) current (Ih) has an important functional role in the rat brain, participating in network oscillations, temporal summation of synaptic inputs, and seizure development. Since hyperexcitability of the amygdala is …
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AMPK-MEDIATED LONG-TERM REGULATION OF HCN4CONTRIBUTES TO AGE-RELATED SINUS BRADYCARDIA
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels mediates inward depolarizing currents, called If in the heart and Ih in the brain, that contribute to the regulation of neuronal excitability and cardiac rhythm. Among the HCN isotypes, HCN4 stands out for its prominent role in …
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ΦΩΣΦΟΡΥΛΙΩΣΗ ΠΡΩΤΕΙΝΩΝ ΣΕ ΣΥΣΤΗΜΑ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ ΕΛΕΥΘΕΡΟ ΚΥΤΤΑΡΩΝ ΑΠΟ ΣΥΚΩΤΙΠΟΝΤΙΚΟΥ. ΚΑΘΑΡΙΣΜΟΣ ΚΑΙ ΧΑΡΑΚΤΗΡΙΣΜΟΣ ΜΙΑΣ ΝΕΑΣ ΚΙΝΑΣΗΣ ΠΡΩΤΕΙΝΩΝ ΠΟΥ ΡΥΘΜΙΖΕΤΑΙ ΑΠΟ ΚΥΚΛΙΚΑ ΝΟΥΚΛΕΟΤΙΔΙΑ
… BY THE PRESENCE OF ANY OF THE FOUR 3', 5' CYCLIC NUCLEOTIDES. THIS EFFECT WHICH MAY BE EITHER STIMULATORY OR INHIBITORY, DEPENDS ON THE CONCENTRATION OF ATP, ON THE TYPE OF ACTIVATING METAL EMPLOYED AS WELL AS ON THE SUBSTRATE USED. ON THE BASIS OF THE AFOREMENTIONED EFFECTS OF THE 3', 5' …
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