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Showing 1 to 20 of 23 for “"cyclic adenosine monophosphate (cAMP)"”.

  1. Modulation of cyclic adenosine monophosphate (cAMP) signalling and its therapeutic potential: pharmacological characterisation of PDE inhibitors

    Safitri, DewiUniversity of Cambridge2021

    The alteration of intracellular cyclic adenosine monophosphate (cAMP) levels plays important regulatory roles in both physiological and pathological conditions, such as cancer. As the most aggressive form of brain tumour, glioblastoma is currently incurable due to limited treatment modalities. Low …

    cambridge Repository record

  2. THE EFFECT OF SKELETAL MUSCLE-SYNTHESIZED BDNF ON MOTOR NEURON SOMA SIZE AND BDNF PROTEIN ABUNDANCE

    Benson, Sydney2025

    … neuron soma, the BDNF/TrkB complex activates cyclic Adenosine Monophosphate (cAMP) response element binding protein (CREB), leading to transcriptional changes that support neuron dendrite growth and survival. Using a skeletal muscle-synthesized BDNF deficient mouse model, this thesis aims to …

    nmu Repository record

  3. The role of reactive nitrogen species and aged garlic extract on platelet function

    Smith, SLiverpool John Moores University2014

    … targets within platelets, including calcium and cyclic adenosine monophosphate (cAMP). The effect of AGE upon the other cyclic nucleotide, cyclic guanosine monophosphate (cGMP) is currently unknown. The aims therefore of this project are to identify the effect of AGE upon platelet cGMP, as well …

    liverpool-jm Repository record

  4. In vitro progesterone and estrone synthesis by the porcine placenta and endometrium at 30, 60 and 90 days of gestation

    Jeantet, Meriella AnitaVirginia Polytechnic Institute and State University1985

    … human chorionic gonadotropin (hCG) and 3' 5', cyclic adenosine monophosphate ( cAMP) on porcine placental and endometrial production of progesterone (P₄), testosterone (T) and estrone (E₁) at 30, 60 and 90 days of gestation. Duplicate 300 mg samples of placenta, endometrium or both …

    vt Repository record

  5. The MA-10 Cell Line as a Model of insl3 Regulation and Leydig Cell Function

    Strong, Mary E2011

    … in response to luteinizing hormone (LH) via the cyclic adenosine monophosphate (cAMP)/protein kinase A pathway. Additionally, these cells are responsible for producing insulin-like peptide 3 (INSL3), a peptide hormone that is essential for testicular descent. The <em>insl3</em> promoter in Leydig …

    calpoly Repository record

  6. Evaluating luteinizing hormone receptor signaling using the cyclic AMP reporter ICUE3

    Hadhoud, Giuma E., author, Roess, Deborah A., advisor, Barisas, George, advisor, Crans, Debbie C., committee memberColorado State University. Libraries2018

    … activation of G proteins. Evaluating the cyclic adenosine monophosphate (cAMP) level in response to binding of ligand to LH receptors depends on activation of adenylyl cyclase by G proteins and production of cAMP. In this project, fluorescence resonance energy transfer (FRET) methods were …

    colostate Repository record

  7. Post-translational modifications regulate β2-Adrenoceptor signaling in cardiac myocytes

    Liu, RuijieUniversity of Illinois at Urbana-Champaign2011

    … activation of the classic Gs-adenylate cyclase-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway. In the mammalian heart, increasing cAMP-PKA activity leads to phosphorylation of an array of proteins involved in increasing heart contractility and rate. β2AR also has …

    uiuc Repository record

  8. Mechanisms Mediating Adaptive Presynaptic Muting Induction

    Crawford, Devon Christine2014

    … of cultured neurons from the mammalian hippocampus, a well-studied brain region known to be important for learning and memory but susceptible to excitotoxic damage. Calcium serves as a signal transducer during excitotoxicity and many forms of synaptic plasticity, but the signaling cascades in …

    wustl Repository record

  9. Understanding HNF-1β through Identification of Interacting Proteins and Target Genes in the Kidney

    Choi, Yun-Hee2010

    … that control the intracellular concentration of cyclic adenosine monophosphate (cAMP) by catalyzing its hydrolysis. cAMP may play a role in cystogenesis by stimulating fluid secretion and cell proliferation. PDE4C is transcriptionally activated by HNF-1Beta and regulates cAMP levels in mIMCD3 …

    utswmed Repository record

  10. Exploring INSL5 and RXFP4 in the gut-brain axis and their potential role in feeding behaviour

    Woodward, OrlaUniversity of Cambridge2023

    … with feeding. By combining Rxfp4-Cre mice with a cyclic adenosine monophosphate (cAMP) imaging technique, INSL5 was found to reduce intracellular cAMP levels in Rxfp4-expressing cells in the colon, DRG, NG and the ventromedial hypothalamus (VMH), a known feeding centre in the brain. Transcriptomic …

    cambridge Repository record

  11. Regulation of cAMP Signalling to Phospholemman by Phosphodiesterases

    Mak, JasonKing's College London2013

    The ubiquitous second messenger molecule, cyclic adenosine monophosphate (cAMP), regulates a multitude of cellular functions, with Protein Kinase (PK)A being the major effector of its actions. There is increasing evidence to suggest that phosphodiesterases (PDEs), a class of enzymes that …

    kings Repository record

  12. Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets

    Qadri, Marwa2020

    … and study the impact of increasing intracellular cyclic adenosine monophosphate (cAMP) in OA fibroblast-like synoviocytes (OA-FLS) on regulating TGF-β linked expression of fibrotic genes and the contribution of PRG4 and HA to this effect. Also, we studied the significance of PRG4-CD44 interaction …

    chapman Repository record

  13. Mechanisms controlling in vitro progesterone synthesis by the ovine placenta

    Onthank, David CharlesVirginia Polytechnic Institute and State University1983

    … human Chorionic Gonadotropin (hCG), 3’, 5', cyclic adenosine monophosphate (cAMP), luteinizing hormone-releasing hormone (LHRH) or no additional treatment. Progesterone concentration in the medium after incubation were determined by radioimmunoassay. The temporal pattern of in vivo …

    vt Repository record

  14. Modulation of the aquaporin-2 localization in renal principal cells

    Baltzer, Sandrine Marina2022

    … elevated levels of the second messenger 3’,5’-cyclic adenosine monophosphate (cAMP) and the activation of the cAMP-dependent protein kinase (protein kinase A, PKA), the water channel aquaporin-2 (AQP2) is redistributed from intracellular vesicles into the plasma membrane of renal collecting …

    tu-berlin Repository record

  15. Directed Cell Migration: From Single Cells to Collectively Moving Cell Groups

    Guven, Can2014

    … concentration gradient of the signaling molecule cyclic adenosine monophosphate (cAMP). The collective migration model shows that the pattern of migration can be quantitatively described by considering the competition of two processes, the secretion of cAMP by the cells and the degradation of cAMP …

    maryland Repository record

  16. The role of supplementary calcium in submaximal exercise and endurance performance.

    Jawadwala, RehanaUniversity of Central Lancashire2012

    … 2000). An in-vitro model suggesting the role of cyclic Adenosine Monophosphate (cAMP) and phosphodiesterase 3B (PDE 3B) has been implicated in the relationship between calcium and lipolysis (Xue et al., 2001). The objective of the series of studies presented in this thesis was to investigate the …

    cent-lancashire Repository record

  17. The crosstalk between the ERK and the cAMP signalling pathways in PC12 Cells

    Gormand, AmelieUniversity of Glasgow2008

    … neurons. The second messenger 3’,5’-cyclic adenosine monophosphate (cAMP) controls a plethora of cellular events from metabolic to cellular signalling pathways. Over the years, lines of evidence have shown that cAMP is also involved in the regulation of cell growth and cell …

    glasgow Repository record

  18. Identification of molecular signaling pathways underlying human endometrial stromal cell differentiation

    Kaya, HaticeUniversity of Illinois at Urbana-Champaign2014

    … differentiation cocktail containing E, P, and a cyclic adenosine monophosphate (cAMP) analog, cease proliferation and undergo differentiation. In the present study, when ESR1 expression was silenced, the HESC continued to proliferate in the presence of the differentiation cocktail and their …

    uiuc Repository record

  19. Investigating the role of ICL3 in β1-adrenergic receptor activation

    Tandale, AditiUniversity of Cambridge2022

    … to different G proteins or arrestins, results in cyclic adenosine monophosphate (cAMP) response, calcium mobilization, or phosphorylation of extracellular regulated protein kinases. Structural studies have provided detailed insight into the receptor architecture in active and inactive states of …

    cambridge Repository record

  20. Exploring the molecular mechanisms of AMPK-dependent regulation of neuroexcitability

    Said, EsraaThe University of Edinburgh2025

    … channels and murine hyperpolarization-activated cyclic nucleotide-gated (mHCN) channels. hTASK-3 channels belong to the family of two pore domain potassium (K2P) channels, which are voltage- and time-independent channels that are constitutively open over the entire range of physiological membrane …

    edinburgh Repository record

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