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Showing 1 to 20 of 34 for “"cyclic adenosine monophosphate"”.

  1. Characterisation of cyclic adenosine monophosphate/protein kinase A signalling networks in blood platelets

    Raslan, ZaherHull York Medical School, the University of Hull and the University of York2012

    … actions remains unclear beyond the triggering of cyclic nucleotides signaling pathways. The aim of this study was to improve our understanding of platelet regulation by cAMP signaling networks.We observed differences in cAMP signaling depending on the agonists used. Using phosphorylation of PKA …

    hull Repository record

  2. Modulation of cyclic adenosine monophosphate (cAMP) signalling and its therapeutic potential: pharmacological characterisation of PDE inhibitors

    Safitri, DewiUniversity of Cambridge2021

    The alteration of intracellular cyclic adenosine monophosphate (cAMP) levels plays important regulatory roles in both physiological and pathological conditions, such as cancer. As the most aggressive form of brain tumour, glioblastoma is currently incurable due to limited treatment modalities. Low …

    cambridge Repository record

  3. Interrelationships among estrogen, insulin-like growth factor-I and cyclic adenosine monophosphate in the regulation of uterine progesterone and estrogen receptors

    Aronica, Susan MarieUniversity of Illinois at Urbana-Champaign2011

    Studies were undertaken to examine regulation of progesterone receptor gene expression and estrogen receptor bioactivity in uterine cells, and to determine the cellular mechanisms through which various factors mediate regulation of these receptor proteins. Exposure of uterine cells maintained in …

    uiuc Repository record

  4. Direct Measurements of the Effects of Cyclic Adenosine Monophosphate, and Related Compounds, on Membrane Conductances, Intracellular Calcium and Ph in Gastropod Neurons (cyclic-Amp)

    Hockberger, Philip EdwardUniversity of Illinois at Urbana-Champaign2015

    … effects of intracellular injections of cyclic adenosine monophosphate (AMP) and related compounds were examined in identifiable gastropod neurons. Injecting cyclic AMP (or cyclic GMP) in amounts which should have elevated the internal concentration from 0.1-7.6 mM (mean = 3.3 mM) …

    uiuc Repository record

  5. THE EFFECT OF SKELETAL MUSCLE-SYNTHESIZED BDNF ON MOTOR NEURON SOMA SIZE AND BDNF PROTEIN ABUNDANCE

    Benson, Sydney2025

    … neuron soma, the BDNF/TrkB complex activates cyclic Adenosine Monophosphate (cAMP) response element binding protein (CREB), leading to transcriptional changes that support neuron dendrite growth and survival. Using a skeletal muscle-synthesized BDNF deficient mouse model, this thesis aims to …

    nmu Repository record

  6. The role of reactive nitrogen species and aged garlic extract on platelet function

    Smith, SLiverpool John Moores University2014

    … targets within platelets, including calcium and cyclic adenosine monophosphate (cAMP). The effect of AGE upon the other cyclic nucleotide, cyclic guanosine monophosphate (cGMP) is currently unknown. The aims therefore of this project are to identify the effect of AGE upon platelet cGMP, as well …

    liverpool-jm Repository record

  7. Vasopressin kontrolliert die Proteinmenge des Wasserkanals Aquaporin-2 durch Hemmung des proteosomalen Abbaus

    Beulshausen, Sven2021

    … the activation of protein kinase A (PKA) by cyclic adenosine monophosphate (cAMP) leads to the phosphorylation of AQP2, e.g., an increase in serine-256 phosphorylation. In addition, AVP causes activation of the transcription factor CRE (cAMP responsive element) and increased transcription of …

    fu-berlin Repository record

  8. In vitro progesterone and estrone synthesis by the porcine placenta and endometrium at 30, 60 and 90 days of gestation

    Jeantet, Meriella AnitaVirginia Polytechnic Institute and State University1985

    … human chorionic gonadotropin (hCG) and 3' 5', cyclic adenosine monophosphate ( cAMP) on porcine placental and endometrial production of progesterone (P₄), testosterone (T) and estrone (E₁) at 30, 60 and 90 days of gestation. Duplicate 300 mg samples of placenta, endometrium or both …

    vt Repository record

  9. The MA-10 Cell Line as a Model of insl3 Regulation and Leydig Cell Function

    Strong, Mary E2011

    … in response to luteinizing hormone (LH) via the cyclic adenosine monophosphate (cAMP)/protein kinase A pathway. Additionally, these cells are responsible for producing insulin-like peptide 3 (INSL3), a peptide hormone that is essential for testicular descent. The <em>insl3</em> promoter in Leydig …

    calpoly Repository record

  10. Evaluating luteinizing hormone receptor signaling using the cyclic AMP reporter ICUE3

    Hadhoud, Giuma E., author, Roess, Deborah A., advisor, Barisas, George, advisor, Crans, Debbie C., committee memberColorado State University. Libraries2018

    … activation of G proteins. Evaluating the cyclic adenosine monophosphate (cAMP) level in response to binding of ligand to LH receptors depends on activation of adenylyl cyclase by G proteins and production of cAMP. In this project, fluorescence resonance energy transfer (FRET) methods were …

    colostate Repository record

  11. Post-translational modifications regulate β2-Adrenoceptor signaling in cardiac myocytes

    Liu, RuijieUniversity of Illinois at Urbana-Champaign2011

    … activation of the classic Gs-adenylate cyclase-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway. In the mammalian heart, increasing cAMP-PKA activity leads to phosphorylation of an array of proteins involved in increasing heart contractility and rate. β2AR also has …

    uiuc Repository record

  12. Mechanisms Mediating Adaptive Presynaptic Muting Induction

    Crawford, Devon Christine2014

    … G-protein signaling induced silencing through cyclic adenosine monophosphate: cAMP) reduction but surprisingly not via activation of likely candidate receptors. This cAMP reduction contributed to loss of proteins important for vesicle fusion at the presynaptic terminal. I also found that …

    wustl Repository record

  13. Understanding HNF-1β through Identification of Interacting Proteins and Target Genes in the Kidney

    Choi, Yun-Hee2010

    … that control the intracellular concentration of cyclic adenosine monophosphate (cAMP) by catalyzing its hydrolysis. cAMP may play a role in cystogenesis by stimulating fluid secretion and cell proliferation. PDE4C is transcriptionally activated by HNF-1Beta and regulates cAMP levels in mIMCD3 …

    utswmed Repository record

  14. Exploring INSL5 and RXFP4 in the gut-brain axis and their potential role in feeding behaviour

    Woodward, OrlaUniversity of Cambridge2023

    … with feeding. By combining Rxfp4-Cre mice with a cyclic adenosine monophosphate (cAMP) imaging technique, INSL5 was found to reduce intracellular cAMP levels in Rxfp4-expressing cells in the colon, DRG, NG and the ventromedial hypothalamus (VMH), a known feeding centre in the brain. Transcriptomic …

    cambridge Repository record

  15. Synthesis, Pharmacological Characterization and QSAR Modelling of 4-Phenylpiperidines and 4-Phenylpiperazines Effects on the dopaminergic neurotransmission in vivo

    Pettersson, Fredrik2012

    … based on their effect on the production of cyclic adenosine monophosphate (cAMP). The most common dopaminergic receptor used as target for pharmaceuticals is by far the D2 receptor and drugs acting as full agonists, partial agonists and antagonists at this receptor have been developed. In …

    goteborg Repository record

  16. Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets

    Qadri, Marwa2020

    … and study the impact of increasing intracellular cyclic adenosine monophosphate (cAMP) in OA fibroblast-like synoviocytes (OA-FLS) on regulating TGF-β linked expression of fibrotic genes and the contribution of PRG4 and HA to this effect. Also, we studied the significance of PRG4-CD44 interaction …

    chapman Repository record

  17. Regulation of cAMP Signalling to Phospholemman by Phosphodiesterases

    Mak, JasonKing's College London2013

    The ubiquitous second messenger molecule, cyclic adenosine monophosphate (cAMP), regulates a multitude of cellular functions, with Protein Kinase (PK)A being the major effector of its actions. There is increasing evidence to suggest that phosphodiesterases (PDEs), a class of enzymes that …

    kings Repository record

  18. Regulation of duodenal mucosal bicarbonate secretion

    Odes, Harold SelwynDepartment of Medicine1993

    … It was determined that dibutyryl 3' ,5'-cyclic adenosine monophosphate, vasoactive intestinal polypeptide, prostaglandin E2, carbachol and theophylline are the chief agonists of duodenal bicarbonate secretion. Vasoactive intestinal polypeptide and prostaglandin E2 act directly via …

    cape-town Repository record

  19. Mechanisms controlling in vitro progesterone synthesis by the ovine placenta

    Onthank, David CharlesVirginia Polytechnic Institute and State University1983

    … human Chorionic Gonadotropin (hCG), 3’, 5', cyclic adenosine monophosphate (cAMP), luteinizing hormone-releasing hormone (LHRH) or no additional treatment. Progesterone concentration in the medium after incubation were determined by radioimmunoassay. The temporal pattern of in vivo …

    vt Repository record

  20. The role of supplementary calcium in submaximal exercise and endurance performance.

    Jawadwala, RehanaUniversity of Central Lancashire2012

    … 2000). An in-vitro model suggesting the role of cyclic Adenosine Monophosphate (cAMP) and phosphodiesterase 3B (PDE 3B) has been implicated in the relationship between calcium and lipolysis (Xue et al., 2001). The objective of the series of studies presented in this thesis was to investigate the …

    cent-lancashire Repository record

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