Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 113 for “"cyclic AMP"”.
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Cyclic AMP and the Induction of Reactive Astrogliosis
… cyclase. Here I tested the hypothesis that a cAMP-mediated intracellular pathway is involved in eliciting forskolin-induced reactivity in F98 cells, and I attempted to elucidate that pathway using inhibitors of known cAMP-dependent downstream signaling molecules and fluorescent Ca+2 indicators …
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Role of cyclic AMP in exocrine pancreatic secretion
Contains fulltext : mmubn000001_20268962x.pdf (Publisher’s version ) (Open Access)
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Regulation Of Cyclic-amp-dependent Protein Kinases During Skeletal Myogenesis
… myotubes. The regulation of the levels of cAMP-dependent protein kinases during myogenesis in L6 was studied, as these enzymes have been proposed to be involved in the control of this process. Measurement of the mRNA levels for the type I regulatory subunit (R{dollar}sb{lcub}rm …
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Evaluating luteinizing hormone receptor signaling using the cyclic AMP reporter ICUE3
… activation of G proteins. Evaluating the cyclic adenosine monophosphate (cAMP) level in response to binding of ligand to LH receptors depends on activation of adenylyl cyclase by G proteins and production of cAMP. In this project, fluorescence resonance energy transfer (FRET) methods were …
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Investigating luteinizing hormone receptor signal transduction using the cyclic AMP reporter ICUE1
… and development of gonadal tumors. Assay of cAMP levels in response to hormone treatment is usually used to demonstrate LH receptor activation and has historically relied on biochemical methods. ICUEl is an Epac-based cAMP reporter which undergoes conformational changes after binding cAMP. …
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Characterization and localization of a cyclic AMP dependant protein kinase from Dictyostelium discoideum
A developmentally regulated cyclic AMP-dependent protein kinase has been recently reported in Dictyostelium discoideum. This report describes some of the physical and kinetic properties of the cAMP-dependent holoenzyme and its subunits. Gel filtration data suggests a holoenzyme Mr of …
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Endogenous cyclic AMP-dependent phosphorylation in vitro of cytosolic proteins from Dictyostelium discoideum
… slug stage, coincident with the appearance of cyclic AMP-dependent protein kinase. After partial purification by DE-52 cellulose and Sephacryl S-300 chromatography, cyclic AMP dependency of six cytosolic proteins was observed, with apparent subunit molecular weights of > 200,000, 110,000, …
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Cyclic AMP modulation and its effects on chemo-resistant colon cancer cell proliferation and survival
… and survival. Here I use modulators of cAMP pathways, including inhibitors of phosphodiesterase 4 (PDE4) enzymes, which are under clinical development for other disease states, to inhibit the breakdown of cAMP and to assess the effects of raising intracellular cAMP on colon cancer …
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Initiation, Maintenance, and Termination of Bursting in an Endogenously Bursting Molluscan Nerve Cell (cyclic-Amp)
… bursters when the intracellular levels of cyclic 3'5' adenosine monophosphate (cAMP) are raised. cAMP increases the opening frequency of membrane sodium iontophores eliciting an inward current which depolarizes the VWC and leads to action potential bursting and broadening. The opening …
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Micro-analysis of adenylate cyclase and cyclic AMP-dependent protein kinase activities in human mammary tumors
… the enzyme profiles of adenylate cyclase and cAMP-dependent protein kinase within a series of malignant and benign human mammary tumors. The methods allow for determination of enzyme activity in histologically-confirmed neoplastic areas within individual tumors which permits comparisons to be …
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Role of an Adenylyl Cyclase Isoform in Alcohol's Effect on Cyclic AMP Regulated Gene Expression in Mammalian Cells
Research suggests that the cyclic AMP (cAMP) signaling pathway including CREB-CRE regulated expression of various genes is implicated in the predisposition to and development of alcoholism in humans. Alcohol also induces changes in inflammatory and immune responses; these changes increase the …
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In vitro studies of the role of cyclic-AMP in the mammalian circadian clock in the suprachiasmatic nuclei
… focusing in particular on the potential role of cAMP.
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Regulation of the HCMV UL98 Promoter by Cooperation of the Cyclic AMP Response Element and Gamma Interferon Response Element
… sequences were first cloned upstream of the chloramphenicol acetyltransferase (CAT) reporter gene and cotransfected with expression plasmids which express the HCMV major immediate early (IE) proteins 1E72 and 1E86. To more specifically determine the importance of individual cis-acting elements in …
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The cyclic AMP-activated sodium current in the molluscan neuron: A kinetic analysis of regulation by diffusion, phosphodiesterase and calcium ion
Effects of cyclic AMP on pedal neurons of the marine mollusc, Pleurobranchaea californica were studied by intracellular iontophoresis of cyclic AMP under voltage clamp condition. The I$\sb{\rm Na,cAMP}$ response to cyclic AMP injection is resistant to protein kinase inhibitors, and is very likely …
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Direct Measurements of the Effects of Cyclic Adenosine Monophosphate, and Related Compounds, on Membrane Conductances, Intracellular Calcium and Ph in Gastropod Neurons (cyclic-Amp)
… effects of intracellular injections of cyclic adenosine monophosphate (AMP) and related compounds were examined in identifiable gastropod neurons. Injecting cyclic AMP (or cyclic GMP) in amounts which should have elevated the internal concentration from 0.1-7.6 mM (mean = 3.3 mM) …
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Assessing Crosstalk Between Calcium and cAMP in Pancreatic Alpha Cells
… production of the intracellular messenger cyclic AMP. Exocytosis of dense core vesicles containing glucagon ultimately requires an increase in cytosolic calcium. This study focused on the link between cyclic AMP and calcium in pancreatic alpha cells which allows alpha cell regulation. …
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Characterization and localization of adenylate cyclase during development of Dictyostelium discoideum
Cyclic AMP functions as the chemotactic signal during aggregation of single-celled amoebae of the cellular slime mold Dictyostelium discoideum. Evidence suggests that cyclic AMP also acts as a regulatory molecule during Dictyostelium multicellular differentiation. Biochemical characterization of …
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Phototaxis of Dictyostelium discoideum Slugs
… migration. A large body of results suggest that cyclic AMP-mediated cell-cell signaling is the mechanism coordinating multicellular movement. Waves of cyclic AMP generated at the anterior tip propagate towards the tail and induce the chemotactic movement of cells toward the tip. Slugs exhibit …
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