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Showing 1 to 19 of 19 for “"cyclam"”.
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Synthese und Charakterisierung Cyclam-basierter Multimere als Basis für Radiopharmaka
… neuartige mehrfunktionale Verbindungen mit einer Cyclam-Kerneinheit synthetisiert. Cyclam bildet mit Cu(II)-Ionen äußerst stabile Komplexe, was im Hinblick auf eine radiopharmazeutische Anwendung der Radiometallkomplexe von 64Cu oder 67Cu für diagnostische und therapeutische Zwecke äußerst …
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Metal-cyclam based Metal-Organic Frameworks for CO₂ Chemical Transformations
… we aim to develop a new class of metal-cyclam based robust MOFs as porous materials for CO₂ uptake as well as efficient catalysts for CO₂ chemical transformations, including CO₂ chemical fixation, CO₂ photo- and electroreduction. Chapter 1 introduces the concept and main challenges of …
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A modified synthesis, C-functionalization, resolution and racemization kinetics of cross -bridged tetraazamacrocycles
… procedure for the synthesis of cross-bridged cyclam and homocyclen tetraamines are presented. The synthesis involves the use of a cis-tricyclic bisaminal intermediate for the preparation of tetracyclic bisaminals and the microwave-assisted reductive ring opening of N,N'-dibenzyl bisaminal …
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The development of a radiolabelled macromolecule as a therapeutic agent for the treatment of cancer
… a radioisotope through a tetra-amine macrocycle (cyclam), ii) lead to passive tumour targeting via the EPR effect and a suitably large carrier such as human serum albumin and iii) induce active targeting through a glucose moiety recognised by the over-expressed glucose transporters on the surface …
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Chromatographic studies and analytical methods development for selected tetraazamacrocycles and their copper(II) complexes
… evaluated through a competition reaction with cyclam. The estimation of the pKas for a copper (II) complex with methanephosphonate pendant arms is reported. The role of the stationary phase in the determination of the pKa values was investigated using different reversed phase stationary phases. …
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Elektronische Wechselwirkungen in drei- und mehrkernigen cyanidverbrückten Metallkomplexen
… Verbindungen vom Typ trans-[{L´nM´-CN}2ML4] (L = Cyclam, Salen) zeigen, daß Metall-Metall-Wechselwirkungen über ca. 10 Å hinweg in Komplexen mit zentralen M(Salen)-Bausteinen die Regel sind. Substanzen mit zentralen M(Cyclam)-Einheiten zeigen bis auf eine Ausnahme keine solchen Interaktionen. Das …
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Synthetic, structural, and stability studies of metal complexes of cross -bridged tetraamine macrocycles
… of a dicarboxylate pendant-armed cross-bridged cyclam was the most inert, consistent with its superior in vivo stability. This is also in accord with the fact that copper fits best in this ligand as indicated by the largest Nax-Cu-N ax bond angle of this complex compared to other six-coordinate …
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Synthesis of tetraazamacrocyclic complexes: Biomedical applications
… (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) with functional pendent arms and porphyrins with solubilising polyethylene glycol (PEG) chains have been synthesised. The pendent arms possess different properties which tailor the metal complex towards a particular role.
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Synthesis of unsymmetrical pendant-armed and phosphonic acid-pendant-armed cross-bridged tetraazamacrocycles
… of a single pendant-armed cross-bridged cyclam is presented through an unusual single alkylation of cross-bridged cyclam. Several experiments were implemented to probe the origin of the selectivity of the reaction including computational studies, 1D 1H NMR and 2D NMR experiments. …
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Multifunctional bioreducible nanoparticles for gene therapy
… based on 1,4,8,11-tetraazacyclotetradecane (cyclam). We confirmed that the cyclam moieties in the polycations retained their ability to form complexes with Cu(II). The presence of disulfide bonds in the polycations resulted in substantially lower cytotoxicity than control 25 KDa PEI and both …
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Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer
… tetraazamacrocycles based around the cyclam and cyclen structures form thermodynamically stable and kinetically inert complexes with metal ions such as copper(II) and gadolinium(III), and are used in vivo for both imaging and radiotherapy (MRI, PET, radiotherapy).Three convergent …
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Studies of Macromolecule/Molecule Adsorption and Activity at Interfaces
… of bound counter-balancing ions on the metallo-cyclam core was attributed as the cause of the higher θ and faster D through the Ni analogue, which suggests the MOF-epoxide interaction occurs at the metallo-cyclam. This study shed light upon tuning MOF structures for better CO2 sorption and …
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Development of nitrogen protecting groups and synthesis and complexation of bridged bis-tetraazamacrocycles
… in particular the mono-benzyl cross-bridged cyclam system 33, for a variety of biomedical purposes including positron emission tomography (PET) imaging.</p><p>The N-allyl protecting group was also used to synthesize a cross-bridged bis-cyclen 31 that can now be further functionalized for a …
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Ανάπτυξη, βιοκατανομή και φαρμακοκινητική μελέτη πεπτιδικών αναλόγων μπομπεσίνης επισημασμένων με διαγνωστικά ραδιονουκλίδια για την αντιμετώπιση του καρκίνου
… με την τεχνική PET, όπου Υ = [c-carboxylic acid-cyclam] για σύμπλεξη με 64Cu, και Χ = -(ορνιθίνη)3-, (BN-C). Σε όλες τις παραπάνω περιπτώσεις χρησιμοποιήθηκε το τμήμα της φυσικής αλληλουχίας του πεπτιδίου μπομπεσίνη, από το 2o εως το 14ο αμινοξύ, σε συνδυασμό με αμινοξική, θετικά φορτισμένη, …
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Novel Amino Acid Transporter-Targeted Radiotracers For Breast Cancer Imaging
… (EC) and 1,4,8,11-tetra-azacyclotetradecane (N4 cyclam) were selected to coordinate <sup>99m</sup>Tc. These chelators have been reported to provide stable chelation ability with <sup>99m</sup>Tc. By using the chelator technology, the same target ligand could be labeled with different …
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Photo-crosslinked Surface Attached Thin Hydrogel Layers
… HEMA, (b) DMAAm, (c) NIPAAm/DMAAm, (d) NIPAAm/Cyclam. The properties of these polymers were investigated by NMR, UV-VIS spectroscopy, GPC and SPR. Thin hydrogel layers were prepared by spin coating on gold-coated LaSFN9 glass. The covalent attachment to the surface was achieved through an …
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ZnSe Quantum Dots as a platform for solar fuels synthesis
… studied in-depth comprising a phosphonated Ni(cyclam), a Co(quarterpyridine) and a Co(tetraphenylporphyrin) functionalised with three sulfonate groups and one amine group. The latter hybrid photocatalyst exhibited the highest photocatalytic activity (18.6 µmol CO, 27.8 µmol H2) reaching an …
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Zirconium-Based Metal-Organic Frameworks for Artificial Electrochemical Photosynthesis
… reduction. The known CO2 reduction catalyst, Ni(cyclam), is incorporated into a zirconium-based MOF, VPI-100. The VPI-100 powder was electrochemically deposited onto a glassy carbon electrode and the film was used for electrochemical CO2 reduction into carbon dioxide. The film successfully …