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Showing 1 to 6 of 6 for “"cyanide binding"”.
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Carbon-trifluoromethyl bond forming reactions and palladium-catalyzed cyanation of (hetero)aryl halides
… By employing palladacycle precatalysts, cyanide binding during catalyst formation is minimized, allowing for low catalyst loadings even with unactivated aryl chlorides. The method utilizes a non-toxic cyanide source and exhibits excellent functional group tolerance, particularly of free …
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Ligand and Protein Dynamics of CYP3A4
… metabolism in humans. Examples of promiscuity (binding and catalytic) and allosterism in CYP3A4 are ubiquitous but poorly understood. This work is dedicated to improving our understanding of the linkage between ligand binding and protein conformational dynamics with theoretical considerations of …
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Mutagenesis and Spectroscopic Studies on Cytochrome Bd Quinol Oxidase of Escherichia Coli
… aspartate or glutamate, as being involved in the binding of ubiquinol/menaquinol. The NMR study was also the first time that high field proton NMR was successfully applied to such a large membrane protein as cytochrome bd with multiple paramagnetic metal centers. The spectra showed that neither …
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Semisynthetic cytochrome c site-67 substitutions
… and 50 mV respectively. Both analogs had similar binding constants for imidazole, increased approximately 10-fold over the native protein and (Hse-65)cytochrome $c$. In a cyanide binding study, however, (Hse-65, p-F-Phe-67)cytochrome $c$ had a 3- to 5-fold lower binding constant than the other …
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Aspects of the hemes and modulation of hydrogen donors in catalases from bovine liver, yeast, and escherichia coli
… solely protoheme, or heme d-protoheme mixtures. Cyanide binding studies supported this, as ligand binding was monophasic for the bovine, Saccharomyces cerevisiae, and wild type HPII enzymes, but biphasic for several of the HPII mutant proteins. Several mammalian catalases, and at least two …
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Elucidating the role of membranes in modulating the thermodynamics and kinetics of substrate binding to Thromboxane Synthase
Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2013-04-26T15:02:42Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Varma, Snehita.pdf: 1462422 bytes, checksum: 951f441072241284d93adc7f4f9fd9a0 (MD5)