Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"cutaneous T-cell lymphoma"”.
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Expression of Follicular Helper T-cell Markers in Primary Cutaneous T-cell Lymphoma
… and objectives: A distinct subset of T helper cells, named follicular helper T- (TFH) cells, have been recently described. The TFH-cells can be identified on the basis of the expression of several markers including: the chemokine CXCL13; the costimulatory molecules PD-1 and inducible …
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Exploring the genetic landscape in cutaneous T-cell lymphoma with short- and long-read sequencing
Exploring the genetic landscape in cutaneous T-cell lymphoma with short- and long-read sequencing<br /> Carsten Hain<br /> #### Abstract Cutaneous T-cell lymphoma (CTCL) are a group of diseases with heterogenous genetic alterations. In general, there are recurrent copy-number variants and rare, …
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Immunological Mechanisms of Extracorporeal Photopheresis In Cutaneous T Cell Lymphoma and Graft Versus Host Disease
… MECHANISMS OF EXTRACORPOREAL PHOTOPHERESIS IN CUTANEOUS T CELL LYMPHOMA AND GRAFT VERSUS HOST DISEASE</strong></p> <p>Publication No.___________</p> <p>Lisa Harn-Ging Shiue, B.S.</p> <p>Supervisory Professor: Madeleine Duvic, M.D.</p> <p>Extracorporeal photopheresis (ECP) is an effective, …
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Identification of differentially expressed genes in AHI-1-mediated leukemic transformation in cutaneous t-cell lymphoma
… insertional mutagenesis in murine leukemias and lymphomas. Its involvement in human leukemogenesis is demonstrated by gross perturbations in its expression in several leukemic cells lines, particularly in cutaneous T-cell lymphoma (CTCL) cell lines (Hut 78 and Hut 102). Hut 78 is derived from a …
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A candidate gene based investigation of aberrant DNA methylation in the pathogenesis of primary cutaneous T-cell lymphoma
Primary cutaneous T-cell lymphoma (CTCL) is a clinically heterogeneous malignancy of mature skin-homing T-cells. Mycosis fungoides (MF) is an indo¬lent subtype of CTCL whilst Sezary syndrome (SS) is an aggressive leukaemic variant characterised by the presence of malignant Sezary cells in the …
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A study of activation antigens involved in the pathologicalmechanisms and pathways of cutaneous malignant disease withparticular emphasis on cutaneous T cell lymphoma andmalignant melanoma
… correlation. The studies into cutaneous T cell lymphoma (CTCL) and malignant melanoma (MM), presented here involved predominantly immunocytochemical procedures and relate to the investigations into AP-1 protein expression in CTCL and melanocyte activation antigens in MM. …
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An improved synthesis of the HDAC inhibitor trichostatin A
… their specific apoptotic action towards cancer cells. Several hydroxamate HDIs have since been moved on to phase 1 and 2 clinical drug trials, with one having already been approved for treatment of advanced cutaneous T-cell lymphoma. Trichostatin A is one of the most potent known …
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Development of chemical inducers of dimerization for screening competitive histone deactelyase inhibitors
… (SAHA) has been FDA approved for treatment of cutaneous T-Cell lymphoma. Currently, most of the known HDAC inhibitors are non-selective, which causes non-specific binding to the active sites of all HDAC isoforms, including those not involved in cancer. To date, screening for HDAC inhibitors has …
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THE DEVELOPMENT OF SELECTIVE PHOTOSENSITIZERS TO TARGET PATHOGENIC T CELLS AND PREVENT GRAFT-VERSUS-HOST DISEASE
… and alloimmune diseases. In hematopoietic stem cell transplantation, acute graft-versus-host-disease (GVHD) is caused by an attack on the recipient's tissues from donor allogeneic T cells. In cutaneous T cell lymphoma (CTCL), malignant T cells migrate throughout the skin to mediate the disease. …
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Development Of Elisa-Based Hdac Activity Assay For Identification Of Isoform Selective Hdac Inhibitors
… are FDA-approved drugs for the treatment of cutaneous T-cell lymphoma. Human HDAC proteins have high sequence similarity and hence many known inhibitors non-specifically interact with all or most of the eleven HDAC isoforms, leading to possible side-effects. Hence, HDAC inhibitors specific to …
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Ctla-4 transcriptional activation: regulation of induced expression
… T-lymphocyte antigen 4 (CTLA-4) is a T cell surface protein that is homologous to CD28 and binds to the B7 family of ligands. Unlike CD28, CTLA-4 interaction transmits a negative signal in T cells, leading to suppression of proliferation. CTLA-4 is constitutively expressed on regulatory …