Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"cuprizone"”.
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The effect of aging on myelinating gene expression and oligodendrocyte cell densities
… study CNS remyelination during aging, I used the cuprizone (a copper chelator) mouse model. Inclusion of cuprizone in the diet kills mature OLs and demyelinates axons in the rostral corpus callosum (RCC) of mice, which enabled me to characterize age-related changes (i.e., 2-16 months of age) in …
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Myelin Gene Expression: Implications for Alcohol Abuse and Dependence
… The hypothesis was further investigated using cuprizone to model demyelination in B6 mice and test them in a battery of acute ethanol behaviors. Cuprizone-treated mice had a significantly greater duration in LORR (p < 0.01), demonstrating that myelin is an important contributor to the genetic …
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Investigating the role of cellular communication network factor 3 (CCN3) in central nervous system myelination and remyelination
… models of toxin-induced demyelination were used: cuprizone feeding and lysolecithin injection in the spinal cord ventral white matter.<br/><br/>We found that CCN3 is detected in specific anatomical regions of the healthy CNS, predominantly in neurons. Despite this expression, CCN3-/- mice …
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Characterization of Cu-rich aggregates in neurogenic niches of the rodent brain by X-ray fluorescence microscopy
… or rostral migratory stream. Furthermore, the cuprizone mouse model, which reproduces demyelination as observed in multiple sclerosis through dietary Cu chelation, is examined. While X-ray diffraction mapping shows that myelin-rich areas show diminished myelin there is no corresponding decrease …
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Ionic dysregulation in white matter damage
… was established, using direct application of cuprizone to the isolated mouse optic nerve, and protection afforded by glutamate receptor antagonists was determined. Antagonism of AMPA and NMDA receptors acted in synergy to provide greater protection than block of each alone. This effect may …
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CNS Remyelination and the Gut Microbiota
… remyelination in germ-free (GF) mice following cuprizone-induced demyelina- tion. As with the antibiotics-treated mice, there were deficits in inflammation following demyelination, which tended to peak later than in control mice. Finally, I investigated the potential of a therapeutic probiotic …
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The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand
… recovery period following demyelination, after cuprizone treatment. Although EVG/COBI treatment by itself did not cause overt white matter loss in this brain region. Our study demonstrates that EVG, but not RAL, inhibits oligodendrocyte precursor cell differentiation both in vitroand in vivo. …
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Die Rolle des IKK/NF-kappaB Signalweges bei der Myelinisierung, De- und Remyelinisierung des zentralen Nervensystems
In der vorliegenden wissenschaftlichen Arbeit ging es darum, die funktionelle Rolle des klassischen NF-kappaB Signalweges bei der Entwicklung (Myelinisierung), Schädigung (Demyelinisierung) und Regeneration (Remyelinisierung) des Myelins im zentralen Nervensystem (ZNS) aufzuklären. De- und …