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Showing 1 to 14 of 14 for “"cumulative dose"”.
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Comparison of Tumor Shrinkage and Cumulative Dose Distribution For Lung Cancers
… is that they deliver most of their radiation dose to the target volume and deliver no dose to the normal tissue distal to the tumor. Previously, numerous studies have shown unique advantages of proton therapy over intensity-modulated radiation therapy (IMRT) in conforming dose to the tumor and …
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Design and Synthesis of Doxorubicin Conjugated Gold Nanoparticles as Anticancer Drug Delivery System
… in cancer therapy is greatly compromised by its cumulative dose-dependent side effects of cardiotoxicity and tumor cell resistance. For the purpose of addressing these side effects, a gold nanoparticles-based anticancer drug delivery system was designed. Five novel thiolated doxorubicin analogs …
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Dynamic optimization of fractionation schedules in radiation therapy
… the thesis, we consider delivering a different dose each day depending on the observed patient anatomy. Given that a fixed prescribed dose must be delivered to the tumor over the course of the treatment, such an approach results in a lower cumulative dose to a radio-sensitive organ-at-risk when …
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Chemoptherapy Dose Reductions in Palliative Lung Cancer. Evaluating Chemotherapy Dose Reductions following Neutropenia in Palliative Lung Cancer to prevent further Adverse Events
… Neutropenia is a life-threatening and dose-limiting toxicity of palliative lung cancer chemotherapy. Whilst some neutropenias are inevitable, evidence suggests that patients with a previous neutropenic event are 50% more likely to have a further neutropenic event. The aim of this …
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Kaulų mineralų tankio pokyčiai sergant spondiloartropatijomis /
… severe. Significant negative association between cumulative dose of glucocorticoids and BMD changes at the lumbar spine and upper part of the left and right femur were observed.
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Assessment of Collimator Jaw Optimization In Reducing Normal Tissue Irradiation With Intensity Modulated Radiation Therapy
… To evaluate normal tissue dose reduction in step-and-shoot intensity-modulated radiation therapy (IMRT) on the Varian 2100 platform by tracking the multileaf collimator (MLC) apertures with the accelerator jaws.</p> <p><strong>Methods: </strong>Clinical radiation treatment …
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Effective dose estimation for U.S. Army soldiers undergoing multiple computed tomography scans
… tomography (CT). CT delivers more radiation dose than other diagnostic scanning modalities. Trauma patients are at an increased risk of radiation induced cancer because of the cumulative dose effects from multiple scanning procedures. Current methods for estimating effective dose, the …
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Viability of Viruses in Suspended Aerosols and Stationary Droplets as a Function of Relative Humidity and Media Composition
… in solute concentrations, and modulated the cumulative dose of solutes to which viruses were exposed as droplets evaporated. We proposed that the decay of viruses in droplets follows disinfection kinetics. Lastly, we manipulated the chemical composition of media to explore the stability of …
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The effect of Aspalathin on Doxorubicin-induced Cardiotoxicity
… or 0.2 μM aspalathin daily, resulting in a cumulative dose of 1 μM Doxorubicin, 100 μM Dexrazozane and 1 μM aspalathin, respectively. Cell viability and apoptosis were evaluated using ATP and TUNEL assays. Various bioassays (glutathione, catalase, superoxide dismutase and lipid peroxidation) …
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Chemoligand therapy for metastatic castration-resistant prostate cancer
… bearing PSMA<sup>high </sup>C4-2 tumors at a low cumulative dose (1.5 mg/kg). Using a dosage of 0.125 mg/kg qw x3 in castrated male mice bearing PSMA<sup>low </sup>22R<em>v</em>1 tumors, the chemoligand caused tumor growth delay and improved the median survival (31 vs. 42 days, <em>P </em>= 0.009) …
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Insights into the radiation Chemistry of FLASH Radiation Therapy
… modality that delivers radiation at ultra-high dose rates (UHDR) and has shown consistent normal tissue sparing while preserving tumor control compared to conventional RT—a phenomenon termed the FLASH effect. Despite promising results, the mechanisms behind the FLASH effect remain unclear. Many …
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Multi-cycle cisplatin treatment alters spermatogonial functional stem cell behavior and niche
… of repeated cycles of five to seven daily low dose treatments followed by a one to two week recovery period. While effective, this dosing structure results in a prolonged, and sometimes permanent, infertility in men. Undifferentiated spermatogonia, including spermatogonial stem cells (SSCs), …
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A Double-blinded Randomized Controlled Trial on the Effect of Distant Reiki on Pain after Non-emergency Caesarean Section and the Effect of CYP2D6 Variation on Codeine Analgesia
… women’s pain; neither the measured pain nor the cumulative dose of pain medication differed between groups. Moreover, rates of recovery after c-section were also not different between the two groups. This led to the conclusion that distant Reiki was not suitable as a primary method of controlling …
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The analysis of radiation-induced micronuclei in peripheral blood lymphocytes for purpose of biological dosimetry
… it is of great importance to estimate the dose absorbed by exposed persons in order to plan their therapy. Although occasionally in these situations physical dose measurements are possible, most often biological methods are required for dose estimation. The aim of this investigation was to …