Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"cue reactivity"”.
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Working Memory in Posttraumatic Stress Disorder: Trauma Cue Reactivity
… evaluates the effect of trauma and trauma-paired cues on working memory performance. Results demonstrate the emergence of chronic deficits in working memory among traumatized animals three weeks post-trauma. Presentation of trauma-paired cues caused further decrement in working memory performance. …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
… is exposure to environmental and discrete cues previously associated with drug-taking (cue reactivity). Human drug users experience an increase in craving elicited by drug-paired cues over time, and in rodent models, a time-dependent increase in cue reactivity (‘incubation”) is observed …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
… is exposure to environmental and discrete cues previously associated with drug-taking (cue reactivity). Human drug users experience an increase in craving elicited by drug-paired cues over time, and in rodent models, a time-dependent increase in cue reactivity (‘incubation”) is observed …
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Cue reactivity to self-harm cues: the development of a systematic treatment intervention for deliberate self-harm
… DSH. This thesis was designed to identify these cues, to develop an understanding of how those who self-harm respond to these cues and the processes by which these cues may operate to maintain DSH. An intervention based on the management of urges to self-harm in the presence of these cues was …
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Neuroimaging metrics of drug- and food-cue reactivity as a function of psychopathic traits, substance use, and substance dependence
… psychopathy and drug- and food-related neural reactivity. In the first study, we assessed the relationship between psychopathic traits and neural reactivity among 47 cocaine-dependent and 58 non-dependent participants. The cocaine-dependent group exhibited a neural processing bias towards …
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RACIAL STIGMA AND SUBSTANCE USE OUTCOMES AMONG AFRICAN AMERICAN EMERGING ADULTS: A REPLICATION AND EXTENSION
… analyses) to replicate and extend a novel, cue-based paradigm developed to investigate underlying neural mechanisms involved in the immediate context of a racial stigma event. Racial discrimination is a chronic psychosocial stressor for African Americans associated with a broad range of …
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PPARγ agonism attenuates cocaine seeking behavior via association with ERK MAPK
… Our lab demonstrated PPARγ agonism rescued cognitive impairment in an animal model of Alzheimer’s disease and that this rescue involved ERK. Given the role of altered learning and memory circuitry in addiction, and our recent evidence that PPARγ is involved in restoring hippocampal …
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The Effect of Marijuana Craving on Brain Activation and Recognition Memory in Healthy and Bipolar Adolescents
… on tests of brain activation in response to a cue-reactivity task, self-reported craving and performance on a recognition memory task in order to parse the cognitive effects of bipolar disorder and the alteration in cognitive performance related to the effects of craving. We examined fMRI …
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The Effect of Marijuana Craving on Brain Activation and Recognition Memory in Healthy and Bipolar Adolescents
… on tests of brain activation in response to a cue-reactivity task, self-reported craving and performance on a recognition memory task in order to parse the cognitive effects of bipolar disorder and the alteration in cognitive performance related to the effects of craving. We examined fMRI …
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Can Computers Assist Treatment? Virtual Reality as a Possible Cue Exposure Technique With Adolescent Substance Abusers
… the feasibility of a virtual reality (VR) cue reactivity paradigm for adolescent cannabis abusers and to compare it to a video cue reactivity paradigm. Forty-two treatment-seeking youth with a cannabis use disorder completed the study, which incorporated three parts. During Part 1, drug and …
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Eye-Tracking Measures of Attentional Bias In Cocaine Dependent Subjects
… of attentional bias toward cocaine-related cues, and this measure of cue-reactivity is predictive of craving and relapse. In previous work, cue-reactivity and attentional bias have been assessed by models that present drug-relevant stimuli (e.g., cocaine-specific Stroop task) and measure …
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Profiling the Serotonin2 Receptor System Functional Capacity: Towards Identification of a Cocaine Use Disorder Biosignature
… cocaine-dependent subjects who also express high reactivity to cocaine-associated cues (“cue reactivity”) suggesting that impulsivity and cue reactivity are interlocked contributors to relapse, a cardinal facet of addiction. Serotonin (5-HT) neurotransmission through the 5-HT2C receptor (5-HT2CR) …
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The Serotonin (5-HT) 5-HT2A Receptor is a Priority Target to Reduce Impulsive Action in Substance Use Disorders: Preclinical Evidence
… action and the attentional orienting to drug cues (cue reactivity) based upon extensive pharmacological studies with investigational 5-HT2AR antagonists/inverse agonists. We first established the potential for repurposing the recently FDA-approved 5-HT2AR antagonist/inverse agonist …
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Mind the gap: brain-behaviour barriers to successful weight loss maintenance
… exhibit heightened indices of visual food cue-reactivity in various regions of the brain associated with obesogenic eating and reward-seeking tendencies. The novelty of this thesis lies in that we ascertained dietary, PA and psychobehavioural variables through both subjective accounts and …
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Strategies to Identify Therapeutic Opportunities in the Treatment of Addictive Disorders
… between high fat food binge intake and cue reactivity, both of which are modulated by insula activity. Further, the clinically-approved serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist/inverse agonist pimavanserin and 5-HT2CR agonist lorcaserin used alone or in combination …
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The Influence of Hormonal Fluctuation on Stress-Induced Smoking Cravings in Women
… late luteal phase–involving an in-vivo smoking cue task, administered before and after exposure to a psychosocial laboratory stressor. Heart rate variability (HRV) and subjective smoking cravings in response to the pre- and post-stress cues were measured. Furthermore, urinary metabolites of …
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SOCIAL PROBLEM-SOLVING, NEGATIVE AFFECT, AND SMOKING URGE REACTIVITY DURING BASELINE CUE EXPOSURE
… and smoking urges during a baseline smoking cue exposure trial. Methods: aA part of a larger cessation study. 51 male and 50 female physically inactive, sedentary smokers with the intention to quit smoking, and bioverified smoking abstinence (CO < 11ppm) completed demographic questionnaires, …
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Neuroimaging metrics of externalizing disorders: assessing neurobiological features of substance use, withdrawal, substance use disorders, and psychopathy
… prognoses. In addition, studies have used neural reactivity to drug and food rewards to separate cocaine-dependent participants from non-dependent controls, as well as cocaine-dependent with and without a history of withdrawal symptoms and varying degrees of historical cocaine use and psychopathic …
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The cognitive, physiological and behavioural indicators of excessive and regular video gaming
… visuo-spatial ability. Manuscript 6 extends the cue-reactivity and impulsivity investigated in the first two manuscripts by investigating physiological arousal and sensation-seeking in regular and excessive MMORPG and FPS gamers during gaming. The results showed that excessive MMORPG gamers used …
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