Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"ctDNA analysis"”.
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Assessment of the clinical validity of ctDNA Analysis for melanoma management
… are urgently required. Circulating tumour DNA (ctDNA) analysis has emerged as a potential “liquid biopsy” for melanoma. Plasma-derived ctDNA are short DNA fragments released into the bloodstream by apoptotic tumour cells. Studies have shown that ctDNA levels in blood correlate with tumour burden …
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Detection and monitoring of treatment resistance in metastatic cancer through non-invasive DNA methylation-based biomarkers
… on empowering plasma circulating tumor DNA (ctDNA) analysis, as a non-invasive approach for precision oncology, with applications ranging from early detection and minimal residual disease (MRD) assessment to dynamic monitoring of treatment response and molecular profiling in advanced disease. …
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Non-Invasive cancer detection: computational applications in liquid biopsy and radiomics
… comprehensively analyzing circulating tumor DNA (ctDNA), particularly at low ctDNA fractions, and introduces novel tools and strategies to enhance the sensitivity and specificity of ctDNA analysis. The first part of the thesis focuses on the development of Synggen, a tool for generating synthetic …
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Detection of trace levels of circulating tumour DNA in early stage non-small cell lung cancer
… using analytes such as circulating tumour DNA (ctDNA), can detect and quantify cancer in a minimally invasive way and can provide information on tumour heterogeneity. Current limitations in the liquid biopsy field are centred around the general sensitivity of the present assays and the input and …
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Dynamics and utility of cell-free DNA release following radiotherapy in prostate cancer and non-small cell lung cancer
… DNA (cfDNA) can be determined by methylation analysis and circulating tumour DNA identified by next-generation sequencing (NGS). To evaluate the dynamics of cfDNA during radical radiotherapy, total cfDNA was quantified in patients undergoing radiotherapy for prostate and lung cancer; samples …
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Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma
… tumour cells (CTC) and circulating tumour DNA (ctDNA) represent a new generation of biomarkers that can be used for predicting therapy responsiveness and longitudinal monitoring of OC patients undergoing therapy. This thesis describes a series of investigations in OC which include, a …
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Exploring the effect of peri-operative inflammation on systemic and local breast cancer biomarkers
… and influence circulating tumour DNA (ctDNA)release which may predict clinical and oncological outcomes. Aims 1. To understand the relationship between peri-operative systemic inflammation and breast tumour characteristics, surgical intervention and 30-day morbidity in non-metastatic …
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Resolving the evolution of Oesophageal Adenocarcinoma using spatial and temporal sampling
… tissue is through circulating tumour DNA (ctDNA). Liquid biopsy sampling also has been proven to be highly prognostic in multiple cancer types and recent advances in ctDNA detection have now provided a potential avenue for this sampling approach to utilised in OAC. Hypothesis Deciphering …
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Circulating tumour DNA: A non-invasive biomarker for melanoma
… quality of life and survival. The detection and analysis of mutant specific circulating tumour DNA (ctDNA) is an emerging tool for detection of residual disease and for prognosis and monitoring of different cancers (Bettegowda et al., 2014; Dawson et al., 2013; Gray et al., 2015; Spindler et al., …