Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"crystal habit"”.
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Application of machine learning methods for design of crystallisation processes
… the application of ML techniques in aspects of crystallisation process design assessing the ability to predict crystallisation outcomes, including crystal habit and non-aqueous solubility of pharmaceutical drugs in a diverse range of solvents.;High throughput screening for analysing …
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Investigations of hexagonal boron nitride: bulk crystals and atomically-thin two dimensional layers
… applications benefit from high quality, single crystals, with thicknesses varying from nanometers to microns. This research was undertaken to investigate four aspects of hBN crystal growth and recovery. (1) In an effort to optimize hBN crystal growth from a nickel-chromium flux, a series of …
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Modelling the morphology of molecular crystals
… calculations based on a knowledge of internal crystal structure to be carried out. Details of the programs are presented along with the guidelines developed for their use. The programs were used to compare and contrast the current methods employed for relating crystal shape to structure and to …
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Microfluidic systems for continuous crystallization of small organic molecules
… one of the first demonstrations of continuous crystallization in microfluidic devices, and illustrates their use for various applications related to crystallization of small organic molecules. Crystallization is an important process in a number of industries, including specialty chemicals, …
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GROWTH AND MECHANICAL DEFORMATION OF ALPHA-LACTOSE MONOCRYSTALS
This project set out to use monocrystals as the starting point in the study of the mechanical properties and deformation behaviour of alpha-lactose crystals. Chapter 2 conducts a detailed investigation into the crystallisation and growth kinetics of alpha-lactose monohydrate crystals by an agar-gel …
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Diphenylalanine self-assembly- kinetics, thermodynamics and its relevance to amyloidogenesis
… solution into needle-like hollow micro- and nanocrystals that possess advantageous properties such as high stiffness and piezoelectricity and have emerged as attractive candidates for functional nanomaterials. In addition, these structures can be made conductive or used as scaffolds for …
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Investigation of Pharmaceutical Mass Transfer Phenomena Using Molecular Dynamics Simulations
… study included (1) the understanding of drug crystal dissolution at molecular level, (2) the elucidation of an unique mechanism for facile polymorphic transformation of crystalline drugs in solutions, and (3) the determination of drug-polymer interactions at water-crystal interface and the …
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Development of Novel Methodologies for the Electrodeposition of Polypyrrole-based Films in Controlled Morphologies with Potential Application in Nitrate Sensing.
… and PPy. Electrodeposition of copper crystals at PPy and PPyEtCN was performed using constant potential and cyclic voltammetry techniques. For potentiostatic deposition, the concentration of copper and the magnitude of the overpotential were altered to control the deposited crystal …
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Examination of stress-induced transformations within multicomponent pharmaceutical crystals
Crystal engineering has advanced the strategies of design and synthesis of organic solids with the main focus being on improving the properties of the developed materials. Research in this area has a significant impact on large-scale manufacturing as industrial processes may give rise, at various …
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The effect of nanoscale structure on interfacial energy
… at the interface. In materials science, crystallization and the resulting crystal habit are determined by interfacial properties, and interfaces affect diffusion through polycrystalline materials. In nanotechnology, much work on self-assembly, molecular recognition, catalysis, …
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An investigation into the precipitation of Fe(III) oxyhydroxides in lime neutralization processes
… being 0.01 M H2SO4 and 0.01 M and NaOH. The crystal habit was analysed using scanning electron microscopy (SEM) whilst a combination of SEM with EDX was used for composition determination. Transmission electron microscopy was used to determine the morphology and size. The slurry viscosity was …
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Solvent compatible microfluidic platforms for solid form screening of pharmaceutical parent compounds
… compounds are typically determined by screening, crystallization, and subsequent analysis of various solid forms of a compound obtained. Currently the solid form screening process is performed by robotic platforms that require on the order of 0.5 g of material to screen 100 conditions. As a …
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New Developments in the Crystal Chemistry of Selected Borophosphates and Phosphates
… The significant differences in the crystal structures of MISc[BP2O8(OH)] (MI = K, Rb) and CsSc[B2P3O11(OH)3] may be due to the higher coordination number of cesium. Thermal treatment (up to 1000 ºC) of these compounds resulted in white crystalline products containing new phases with …
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The role of lipid in malaria pigment (Haemozoin) formation under biomimetic conditions
… Hz formation under biomimetic conditions. Hz crystals were isolated from mature trophozoites obtained from saponin-lysed iRBCs. Trophozoites were triturated to release digestive vacuoles and subjected to freeze/thaw cycles to release Hz. Supernatant from SDS-washed Hz crystals and solution of …
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Engineering composite particles to overcome the poor pharmaceutical performance of paracetamol
… blending, freeze drying, milling, batch cooling crystallisation, solvent evaporation and cocrystals formation, while, modifying the physicochemical structure of paracetamol crystals to improve tabletability was the rationale. The modified particles, with the desired behaviour acquired, were …