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Showing 1 to 20 of 37 for “"cryptosporidium parvum"”.
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Cryptosporidium Parvum Microbial Adhesion: Interactions Between Sporozoites and Host Cells
Cryptosporidium parvum is a significant protozoal pathogen of both humans and animals worldwide. Since little is known about the mechanisms of attachment and invasion of C. parvum sporozoites to host cells, our goal was to elucidate the mechanism of sporozoite recognition of receptors on the host …
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Novel Nucleic Acid Sensors for the Rapid Detection of Cryptosporidium Parvum
… first customized them for detecting particularly Cryptosporidium parvum, a pathogen whose detection is important, yet presents many challenges. Chapter 2 of this thesis presents a novel test-strip for the detection of C. parvum. The test-strip is designed to detect nucleic acids rather than …
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Fatty Acid-Mediated Inhibition of Host Cell Invasion by Cryptosporidium Parvum
… digests an unsaturated fatty acid that inhibits Cryptosporidium parvum sporozoite invasion of host cells in vitro. A panel of similar lipids with varying chain lengths and degrees of saturation were tested for evidence of inhibitory activity in order to determine the range of specificity. We …
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Understanding the molecular mechanisms controlling gametogenesis and virulence in Cryptosporidium parvum
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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Lifecycle Progression And The Sexual Development Of The Apicomplexan Parasite Cryptosporidium Parvum
Cryptosporidium has emerged as one of the leading causes of diarrhea induced-mortality in children and immunocompromised HIV+ individuals. Other than the acute infection, chronic and asymptomatic cryptosporidiosis results in stunted physical and mental development in children. Drugs and vaccines …
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Roles of surface interaction on Cryptosporidium parvum oocyst transport in subsurface environment
The influence of Cryptosporidium (C.) parvum oocyst and collector surface properties on transport of C. parvum oocysts and microspheres was studied with a radial stagnation point flow (RSPF) cell and 2-dimensional (2-D) micromodels. The quartz or natural organic matter coated quartz surfaces were …
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Modeling fate and transport of Cryptosporidium parvum and rotavirus in overland flow
… of microbial pathogens in drinking water. Cryptosporidium parvum (C. parvum) has been recognized as one of the most frequently occurring microbial contaminants that can cause infection and diarrhea in many mammalian hosts, including humans. About 403,000 of an estimated 1.61 million …
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Effect of Metabolic Enzymes on Amylopectin Content and Infectivity of Cryptosporidium parvum
… stores and subsequently infectivity of Cryptosporidium parvum oocysts/sporozoites in both fresh oocysts and stored oocysts. In addition, glycolytic enzymes and substrates: glucose, glucose-1-phosphate, and glycogen synthase were investigated to determine if they can be used to increase …
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Study of the Cryptosporidium parvum DHFR-TS in the model system Saccharomyces cerevisiae
Cryptosporidium parvum is a ubiquitous protozoan that causes severe gastrointestinal disease. The severe diarrhea that results can be life-threatening, particularly for the very young, old, and immune-compromised. Currently there is no approved therapy for cryptosporidiosis. We have developed a …
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Uncovering the role of a Cryptosporidium parvum thrombospondin protein (CpTSP8) in host cell attachment
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Evaluation of chemical treatments and ozone on the viability of Cryptosporidium parvum oocysts in fruit juices
<i>Cryptosporidium parvum</i> is a protozoan parasite historically associated with waterborne and more recently foodborne outbreaks of diarrheal illness. Contamination of certain foods, such as unpasteurized apple cider, with infective oocysts may occur as oocysts are shed in the feces of common …
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The Inactivation Kinetics of Cryptosporidium Parvum in Sequential Disinfection Treatment Strategies Using Ozone, Hypochlorous Acid and Monochloramine
Experiments investigating the causes of the enhancements were performed using various combinations of disinfectants in series. The results of these experiments provided evidence that ozone, hypochlorous acid and monochloramine react with similar constituents in the oocyst wall. However, only ozone …
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Detection of Giardia lamblia and Cryptosporidium parvum in the eastern oyster (Crassostrea virginica) harvested from the Great Bay Estuary
… the protozoan pathogens, Giardia lamblia and Cryptosporidium parvum are present. The development of a rapid and sensitive technique to detect infectious protozoa in oysters is a necessity.</p><p>Immunofluorescence has been employed as a technique for the detection of these organisms in …
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The Novel Long Non-Coding RNA Nostrill Regulates Intestinal Epithelial Defense Against Cryptosporidium parvum and Modulates Microglial-Mediated Neurotoxicity
… the intestinal epithelium following infection by Cryptosporidium parvum, a globally prevalent protozoan parasite that causes significant diarrheal disease and an important opportunistic pathogen in the immunocompromised. Induction of Nostrill was triggered by NF-κB signaling and was observed to …
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A Comparative Study of Synergistic Effects in Sequential Inactivation of Cryptosporidium Parvum Oocysts and Bacillus Subtilis Spores With Chemical Disinfectants
… disinfection strategies for the control of Cryptosporidium parvum oocysts in drinking water treatment, very limited work has been done on identifying and characterizing the interactions among chemical disinfectants and oocyst components involved in parasite inactivation. Furthermore, no …
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Assessment of the fate of Cryptosporidium parvum, Giardia lamblia and Ascaris lumbricoides in class A composting and class B lime stabilization biosolids treatment processes
… is Ascaris lumbricoides. Protozoans including Cryptosporidium parvum and Giardia lamblia were not considered human pathogens when the Part 503 rule was written, but are present in biosolids materials using the recovery methods developed in this project. Through the use of these methods, the …
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The Effects of E-Beam Irradiation, Microwave Energy and High Hydrostatic Pressure on Presence and Health Significance of Cryptosporidium parvum in Eastern Oysters (Crassostrea virginica)
… outbreaks associated with the protozoan parasite Cryptosporidium spp. are an emerging public health concern. Shellfish, including Eastern oysters (Crassostrea virginica) in Chesapeake Bay and other Atlantic coastal waters, have been identified as a potential source of Cryptosporidium parvum …
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High Throughput Screening of Aptamers
… using whole organisms/cells (live <em>Cryptosporidium Parvum</em> oocysts), protein targets (<em>a</em> thrombin, as well as <em>Cryptosporidium Parvum</em>'s surface proteins, Cp23 and Cp15) and small molecule targets (<em>a</em> thrombin's glycan moiety and saccharides). We …
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