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Showing 1 to 6 of 6 for “"cryptophanes"”.
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'Amplifying' the NMR signatures of host-guest interactions and molecular structure using liquid-crystalline matrices and polarization enhancement of nuclear spins
… the procedures for synthesizing many of the cryptophanes used in the NMR experiments in this dissertation. The cryptophanes synthesized include cryptophane-A, cryptophane-223, and cryptophane-E as well as the water-soluble derivatives of each. The eighth and ninth chapters investigate the …
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New Cyclophanes as Supramolecular Scaffolds: The Synthesis of Tribenzo-1,4,7-Triazacyclononatriene.
… block enabling the construction of more complex cryptophanes. The goal of this research is the synthesis and characterization of a novel cyclophane, tribenzo-1,4,7-triazacyclononene and derivatives thereof. These new cyclophanes should have greater versatility than the parent hydrocarbon …
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Cryptophane Derivatives as Gas Sensors and Hyperpolarized Xenon-129 Biosensors
… describes the progress in the development of cryptophanes for three different applications: encapsulation of noble gases, 129Xe NMR biosensing for cancer detection, and the construction of molecular devices. A new water-soluble organic host molecule, tris-(triazole ethylamine) cryptophane, was …
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Structure, Function and Applications of Metal-Requiring Enzymes: Carbonic Anhydrase and Epi-Isozizaene Synthase
… for Targeting Human Carbonic Anhydrase Cryptophanes represent an exciting class of xenon-encapsulating molecules that can be exploited as probes for nuclear magnetic resonance imaging. A series of carbonic anhydrase-targeting, xenon-binding cryptophane biosensors were designed and …
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NOVEL EXPERIMENTAL APPROACHES AND THEORETICAL MODELS FOR IMPROVING SENSITIVITY AND INFORMATION CONTENT OF NMR AND MRI SPECTROSCOPY
… in an effort to contribute to this field. First, cryptophanes are cage-shaped molecules that have previously been used to encapsulate molecules of interest for a number of potential applications--including gas sensing and biosensing. In one set of studies, encapsulation of molecular hydrogen gas …
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SPECTROSCOPIC STUDIES OF NUCLEAR SPINS POLARIZED VIA SPIN EXCHANGE OPTICAL PUMPING AND DYNAMIC COUPLING IN CRYPTOPHANE HOST-GUEST COMPLEXES
NMR is a powerful analytical spectroscopic tool used to perform detailed studies of structure and dynamics of molecules in solution. However, despite NMR's excellent spectral sensitivity, most NMR methods suffer from low detection sensitivity. This low detection sensitivity results largely from …