Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"cryptochrome"”.
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Ultrafast Dynamics of Flavin Cofactor in Photolyase/Cryptochrome Family
… cofactor in four redox states in photolyase/cryptochrome family proteins. In photolyase, the antenna molecule MTHF absorbs a photon and transfer the excitation energy to the catalytic cofactor FADH¯ to enhance the DNA-repair efficiency. With the femtosecond-resolved fluorescence and transient …
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Plant-Like Cryptochrome Does Not Promote Blue Light-Induced Resetting of the Circadian Clock in <i>Chlamydomonas Reinhardtii</i>
… a photoreceptor must be involved, and plant-like cryptochrome was the most probable candidate, as it is known to perform this function in higher plants. To determine if plant-like cryptochrome serves this function, available transformants of <em>C. reinhardtii</em> with an RNA interference …
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Cloning of "Animal Cryptochrome" cDNA from the Model Organism <i>CHLAMYDOMONAS REINHARDTII</i> for Functional Analysis of Its Protein Product
… a model organism to study the circadian clock. Cryptochromes are the blue light photoreceptors that entrain the clock in some organisms. The CPH1 protein of <i>C. reinhardtii</i> resembles the cryptochromes of the plant model <i>Arabidopsis</i>, but whether CPH1 entrains the circadian clock in …
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Magnetic orientation in migratory birds
… sind die Schlüsselfragen meiner Doktorarbeit. Cryptochrome werden als potentielle Magnetfeld-Rezeptoren vorgeschlagen. Ich konnte vier Cryptochrom-Varianten in der Retina von Gartengrasmücken identifizieren, und das retinale Expressionsmuster von Cry1a der Gartengrasmücke (gwCry1a) analysieren. …
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The Gsk-3Β-Fbxl21 Axis Regulates Tcap Via Ubiquitin-Mediated Proteasomal Pathway In The Cytoplasm
… activities targeting the core clock proteins CRYPTOCHROME(CRY)1/2. Here we identified a new sarcomeric target substrate, Telethonin(TCAP), which also shows circadian oscillation in its mRNA transcript and protein expression and, importantly, interaction with FBXL21 in an anti-phasic manner. …
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Spatiotemporal memories in honey bees: microarray analysis of time-trained foragers
… of circadian rhythms, such as period and cryptochrome, appear to change in expression with activity state rather than time of day. Overall, these results indicate that distinct spatiotemporal foraging memories in honey bees are associated with distinct neurogenomic states involving genes …
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Interrogation and control of mammalian transcription
… in combination with the light-inducible dimer cryptochrome 2 - cibi from Arabidopsis thaliana. Light enables fast and reversible recruitment of transcriptional effector domains to the TALE bound to the endogenous target promoter through dimerization of cryptochrome 2 - cibi. I applied LITEs to …
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Taming Quantum Noise in the Open: Spin Biophysics under Optimal Control
… of the proposed radical pair quantum compass in cryptochrome closer to approaching the quantum Cram\'{e}r-Rao bound. Remarkably, this approach to optimality is amplified under environmental noise and persists with increasing complexity of the spin system, suggesting that perturbations inherent to …
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Engineering Optogenetic Control of Endocytic Recycling: Controlling Rab11 Function in Drosophila melanogaster using Engineered Light-Responsive Nanobodies
… utilizing an optogenetic, light-sensitive Cryptochrome 2 (Cry2) fused to YFP-targeting nanobodies to bind functional, endogenous, YFP-tagged Rab11. This system promises to provide precise light-responsive spatio-temporal control of Rab11 function in response to blue-light exposure through …
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Quantum Coherence and Entanglement in Open Quantum Systems
… in the first part. It is demonstrated that Cryptochrome is a suitable candidate of the primary magnetoreceptor, located in birds' eyes. Also, the product yields due to the radical pair reactions are able to act as the direction signal for birds. The long-lived quantum entanglement has …
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Analysis of the regulation of GIGANTEA transcript and protein accumulation in Arabidopsis and recombinant expression
… demonstrated that PHYTOCHROME A, ZTL, and CRYPTOCHROME 1 (CRY1) and/or CRY2 are responsible for the regulation of GI mRNA cycling. The same photoreceptors are involved in post-transcriptional regulation of GI, with CRY1 and/or CRY2 seemingly causing de-stabilisation of GI in the dark. …
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Functional investigation of PERIOD in the mammalian circadian clock
… transcription of the Period (Per) and Cryptochrome (Cry) genes. Whilst Per clock genes are essential for circadian rhythmicity, little is known about the cell-autonomous mechanisms that confer 24h organisation to the activity and subcellular localisation of PER-containing complexes. In …
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Circadian Orchestration of the Cellular Proteome
… Strikingly, by using a genetic knock-out of the CRYPTOCHROME (CRY) proteins I found that the generation of these rhythms was not dependent upon the TTFL, strongly supporting an alternative model of circadian rhythm generation – the post-translational oscillator (PTO) model. In the next chapter I …
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Effects of Light on BDBT Puncta Formation in the Drosophila Eye Reveal Involvement of BDBT with Color Preference Behavior and Distinct Nuclear Localization Pathways for DBT and PER
… Analysis of circadian loss of function CRYPTOCHROME (cry) mutants and mutants of the RHODOPSIN 1(ninaE) visual transduction pathway indicated that disappearance of cytosolic BDBT foci in response to light is dependent upon both the CRY and the RHODOPSIN-1 visual transduction pathways. …
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Understanding and engineering photoresponses in Arabidopsis thaliana
… sensitive phytochromes, the blue light sensitive cryptochromes, phototropins and zeitlupe family and the UV-B receptor UVR8. The role of phototropins in the maintenance of circadian rhythms in the chloroplast has been recently identified, suggesting the potential for further involvement of …
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Comparative analysis of transcriptome of fracture healing under normal and hypophosphatemic conditions
… to later times showed Sonic Hedgehog (SHH) and Cryptochrome 2 (CRY2) emerging as potential regulators, indicating involvement in osteoblast behavior, differentiation, and circadian rhythm regulation. Temporal Group 2 showed the genes that shifted from later to earlier time showing activation of …
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Interlocking mechanisms regulating the circadian clock response to DNA damage
… Locomotor Output Cycles Kaput) and CRY1 (CRYPTOCHROME 1) were phosphorylated in response to radiation. Taken together, these results indicate that radiation-induced clock phase shifts involve the activity of kinases ATM, ATR and CHK2, and the modification in CLOCK and CRY1. Chapter 4 is a …
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Licht- und Redoxregulation von Calcium-permeablen Kanälen in Arabidopsis thaliana Mesophyllzellen
… Beteiligung weiterer Blaulicht-Rezeptoren, der Cryptochrome, ausgeschlossen werden. 3. Neben Blaulicht aktivierten auch reaktive Sauerstoff-Spezies (ROS) Hyper-polarisation-abhängige, Calcium-permeable Kanäle. Protoplasten mit intaktem Cytoplasma (cell-attached Konfiguration) zeigten nach …
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Action Spectrum for Photoentrainment of the Circadian Clock in Wild-Type <i>Chlamydomonas reinhardtii</i>
<p>The circadian clock is an endogenous timer that oscillates with a period of approximately 24 hours and is reset upon environmental time cues such as the daily light/ dark or temperature cycles. <em>Chlamydomonas reinhardtii</em> is an ideal model organism for research on the circadian clock, …
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REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY SYNTHETIC AHR AGONIST BETA-NAPHTHOFLAVONE IN MICE
… Output Cycles Kaput (CLOCK), Period (PER), Cryptochrome (CRY), Nuclear Receptor family1 D1 (REV-ERB) and Retinoic acid-related Orphan Receptor (ROR). Circadian clock disruptions, through environmental changes to light-dark cycles or through genetic modification of core clock genes cause …
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