Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 113 for “"crypt"”.
-
A Crypt within a Dystopia
… of daily life are integrally linked to the crypt.
-
SIGNALLING TISSUE RENEWAL AND CRYPT SURVIVAL IN THE HUMAN COLONIC EPITHELIUM AND BARRETT’S OESOPHAGUS
… organised into millions of invaginations called crypts, each of which represents the self-renewing unit of the tissue. In the mouse, renewal of the intestinal epithelium is regulated by signalling cross-talk between the Wnt, Notch, EGF and TGFβ/BMP pathways. The molecular mechanisms that regulate …
-
Impact of Adiposity Status on the Association of Regular Statin Use and Increased Number of Aberrant Crypt Foci
… reports suggesting an increased risk of aberrant crypt foci and adenoma. We hypothesize that insufficient control of confounding due to indication bias for prescribing of statins, particularly obesity-induced physiologic dysregulation, might partly explain discrepant results. <strong>METHODS: …
-
Nuclear Rna Polymerase Activity in the Rat Intestinal Epithelium: A Comparison of Undifferentiated Crypt Cells and Differentiated Villus Epithelial Cells
Made available in DSpace on 2014-12-11T22:22:27Z (GMT). No. of bitstreams: 1 7514193.pdf: 4868084 bytes, checksum: febe65990dc399728e8f41180da2133d (MD5) Previous issue date: 1975
-
Watchful witnesses : a study of the Crypt Memory and Witness Centre at St George's Cathedral and its Bearing Witness exhibition process
… examines four themes that surface through the Crypt Centre's activities towards its upcoming exhibition entitled Bearing Witness. The themes include the role of remembrance, bearing witness, the parameters of inclusions and exclusions, and the Crypt Centre's physical and symbolic significance.
-
Small Proline Rich Protein-2 Expression and Regulation in the Caco-2 model of Intestinal Epithelial Differentiation along the Crypt-Villus Axis
… intestinal epithelial differentiation along the crypt-villus axis, we hypothesized that SPRR2 would be preferentially expressed in post-confluent differentiated Caco-2 cells and examined SPRR2 regulation by the protein kinase A pathway (PKA) and short chain fatty acids (SCFAs). …
-
The impact of positive margins and crypt involvement in excisional procedures of the cervix on recurrence rates of premalignant diseases of the cervix
… We aim to determine if positive margins and crypt involvement increased the rate of recurrence of premalignant disease in patients who had excisional procedures. METHODS In this retrospective review of the colposcopy database, patient records and pathology database, women who had cervical …
-
Wnt Signals and Imaging Tissue Renewal in the Human Colonic Epithelium
… of flask-like epithelial invaginations known as crypts. Within these crypts reside a stem cell population that continuously repopulates the epithelium with all of its specialised cell lineages. Many signalling pathways are involved in the regulation of these activities, the predominant one being …
-
Repair and restitution in the gastrointestinal tract after exposure to a cancer chemotherapy drug.
… of rapidly dividing cells from the intestinal crypts and collapse of crypt / villus structure. By 2 days, few progenitor cells were evident. Nonetheless, cell division re-started thereafter and the stem cell population re-established. This did not, as expected, result in restoration of the …
-
Accumulation of Somatic Mutations in Normal Human Colonic Epithelium
… clonal expansion beyond the boundary of a single crypt is recognised by clones occupying multi-crypt patches. Quantification of such events allows the rate of lateral expansion for different mutations to be measured. Moderate effects were found for PTEN, p53 and STAG2, while mutations in the …
-
Behavioral and genetic characteristics of intestinal cell lineages in health and disease
The intestinal crypt is a highly dynamic system, as the entire epithelium is constantly turned over and renewed by the proliferative stem cells located at the bottom of the crypt. While this system is crucial for nutrient absorption, any derangements in the proliferative cells can quickly lead to …
-
Intestinal Mucosal Mast Cell Immune Response and Pathogenesis of Two Eimeria Acervulina Isolates in Broiler Chickens
… duodenal lesions and reduced villus height to crypt depth ratios when compared to controls; however, no differences were found in mast cell counts. EA2 produced differing results, and observed data were suggestive of an intestinal secretory response when compared to EA1 or controls. In …
-
Mechanism and role of calcium in excitation-mucus secretion coupling in human colonic epithelium
… using an ex-vivo 3D model native human colonic crypt model system. Immunohistochemistry revealed the presence of cholinergic neurons in close proximity to the basal membrane of the crypts, where the muscarinic receptor (M3AchR) was expressed. Fura-2 Ca2+ imaging demonstrated that Carbachol (Cch) …
-
Effects of early nutrition on the wnt and bone morphogenic protein pathways in the developing intestine
… is known to exist in a gradient along the crypt-villus axis, with Wnt expression dominating in the crypt region and BMP expression dominating in the villi, it was possible that pooling whole tissue reduced our ability to detect treatment effects that would be concentrated in either region. …
-
Selective irradiation of the vascular endothelium
… endothelial cell apoptosis and intestinal crypt stem cell death was evaluated using uniform whole-body and selective vascular irradiation techniques. Mice received whole-body epithermal neutron beam irradiation. Additional dose was selectively targeted to endothelial cells from the …
-
Impact of intestinal bacteria on the anatomy and physiology of the intestinal tract in the PRM/Alf mouse model
… of the lamina propria, villus length and crypt depth [1]. Gut microbiota-derived factors have been proposed to also play a role in the development of a 30 % longer intestine, that is characteristic of PRM/Alf mice compared to other mouse strains [2, 3]. Polyamines and SCFAs produced by gut …
-
Morphological Features of Dysplastic Progression in Epithelium: Quantification of Cytological, Microendoscopic, and Second Harmonic Generation Images
… (up to 85% sensitivity) extract colorectal crypt area and circularity data, which could minimize the burden of training on clinicians. In addition, we proposed fluorescein as an alternative fluorescent dye, providing comparable crypt area and circularity information. </p> <p>In order to …
-
CALCIUM SENSING RECEPTOR FUNCTION IN COLON: A ROBUST PROMOTER OF DIFFERENTIATION AND TUMOR SUPPRESSOR
… sensing receptor (CaSR) in the human colonic crypt epithelium is linked to cellular differentiation while its lack of expression is associated with undifferentiated and invasive colon carcinoma. Recent studies show that CaSR suppresses the malignant phenotype through a variety of pathways that …
-
Visualization and quantification of autophagy in primary gastrointestinal epithelia cell cultures.
… lines and then extended to study human colon crypts cultures transduced by adenoviral vectors expressing GFP-LC3. In comparison to cell lines after starvation, there were less GFP LC3 puncta in the smaller epithelial cells from colon crypt tissue (20-30 compared to 5.8+/-2.2). MDP generated …
-
Regulation of duodenal mucosal bicarbonate secretion
… cytoplasm of cells in the villus as well as the crypt cells, implying that bicarbonate secretion occurs along the length of the villus and crypt. In summary, the present research has shown direct stimulation of duodenal bicarbonate secretion by vasoactive intestinal polypeptide, which …
Page 1 of 6