Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 498 for “"crosstalk"”.
-
Signaling crosstalk in cancers
Deregulation of cellular signaling contributes to the malignant phenotype of cancer. In this dissertation, cross-talk among oncogenic signaling pathways was investigated in two common human cancers. \r\n Pancreatic cancer has a well known spectrum of genetic alterations, among which KRAS mutation …
-
Crosstalk Signaling Between cAMP and mTORC1
The mammalian target of rapamycin complex 1 (mTORC1) senses multiple stimuli to regulate anabolic and catabolic processes. G-protein-coupled receptors (GPCRs) paired to Gs proteins increase cyclic adenosine 3'5' monophosphate (cAMP) to activate protein kinase A (PKA), which phosphorylates Raptor …
-
Electrical crosstalk in multilayer ceramic substrates
Electrical crosstalk is becoming increasingly important as size shrinks and component densities increase in hybrid circuits. This occurs especially in multilayer thick film circuits. Crosstalk studies at high frequencies apply transverse electromagnetic (TEM) or quasi-TEM mode. However, the TEM …
-
Steroid receptor crosstalk in breast cancer cells.
… investigate and characterise GR, ER, and FoxA1 crosstalk in three estrogenic breast cancer cell lines, MCF-7, ZR-75-1, and T-47D cells. It has been determined that the combination of dexamethasone (Dex) and E2 have an altered affect on the cell proliferation of breast cancer cells, compared to …
-
Multi-layer, Low-crosstalk Integrated Optical Switches
… optical switching technologies with ultra-low crosstalk, high bandwidth, and nanosecond-scale reconfigurability. This work presents a comprehensive study of 3D Si-SiN-SiN tri-layer optical switches employing switch-and-select (S&S) architectures for strictly non-blocking connectivity. The 3D …
-
Minimizing distortion and crosstalk in asymmetric channeling
Thesis (M.S.) Massachusetts Institute of Technology. Dept. of Electrical Engineering, 1953.
-
Crosstalk in direct detection optical FDMA networks
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1991.
-
The Crosstalk Between DNA Mismatch Repair and Replication
DNA replication fidelity relies on DNA mismatch repair (MMR) and the proofreading nuclease activity of DNA polymerases. Normally, biosynthetic errors can be removed by the polymerase's proofreading nuclease activity upon their incorporation, and those errors that have escaped the proofreading …
-
Crosstalk between DNA end resection and RNA metabolism
… licensing homologous recombination. Recently, a crosstalk between DNA Damage Response (DDR) and RNA metabolism at different levels has been discovered. Thus, in this Thesis we studied this relationship deeply. We described that the splicing complex SF3B is involved in in DNA damage repair. …
-
REEP5-MFN1/2 tethering in ER-mitochondria crosstalk
Eukaryotic cells utilize membrane contact sites (MCSs) to mediate communication between organelles, with mitochondria-ER contact sites (MERCs) being among the most extensively studied due to their essential roles in maintaining cellular homeostasis. MERCs facilitate critical processes, including …
-
Crosstalk between CX3CL1 and the Cytoskeleton during Vascular Inflammation
The ability of the cortical actin cytoskeleton to regulate the lateral diffusion of plasma membrane molecules is a fundamental guiding principle underlying many cellular processes. By creating and stabilizing diffusional barriers, the cytoskeleton can precisely regulate the association or …
-
Opposing Crosstalk between Rho1 and Cdc42 in Epithelial Morphogenesis
… not F-actin activated JNK. Therefore, opposing crosstalk between Rho1 and Cdc42 dictates epithelial cell shape, junctions, and compensatory proliferation during morphogenesis.
-
Crosstalk between colorectal cancer cells and tumour-associated macrophages
… intestinal epithelial cells. CD47 is involved in crosstalk between colon cancer cells and macrophages by interacting with its ligand signal-regulatory protein α on macrophages. This interaction enhanced cell migration of CRC cells and TAMs. IL-8 and LTD4 could induce CD47 expression in CRC cells. …
-
Crosstalk mitigation of high-speed interconnects using modal signaling
… decomposition of coupled transmission lines to crosstalk mitigation of high-speed interconnects, in particular far-end crosstalk (FEXT), which is the dominant noise source for modern single-ended memory links. Special attention is devoted to addressing the issues that arise over realistic …
-
Dissecting cellular crosstalk and genetic perturbations in haematopoietic regulation
Haematopoietic stem and progenitor cells (HSPCs) proliferate and differentiate to produce a large number of mature blood and immune cells on a daily basis while maintaining themselves as the reservoir for lifelong haematopoiesis. Haematopoiesis is dynamically regulated by activating …
-
Crosstalk Signaling Between Circadian Clock Components and Iron Metabolism
Circadian rhythms are daily molecular oscillations within cells ranging from prokaryotes to humans. This rhythm is self sustaining, and receives external cues in order to synchronize an organism's behavior and physiology with the environment. Many metabolites utilized in metabolic processes seem to …
-
Noise and crosstalk analysis of all-optical time division demultiplexers.
… a lack of understanding regarding the noise and crosstalk characteristics of all-optical demultiplexers. This PhD study attempts to investigate noise and crosstalk performance of two types of all-optical time division demultiplexers, namely nonlinear optical loop mirror (NOLM) and terahertz …
-
Ras Drives Malignancy Through Stem Cell Crosstalk with the Microenvironment
… and trigger self-propelling, aberrant signaling crosstalk with their tissue microenvironment that drives their malignant progression. Surprisingly, the non-genetic, dynamic cascade of crosstalk involves pathways often mutated in advanced metastatic SCCs with a high mutational burden. Coupling our …
-
Understanding the Role of Hypusine Biosynthesis in Endocrine-Exocrine Crosstalk
Traditionally, the exocrine and endocrine cellular compartments of the pancreas have been considered distinct functional systems. However, recent studies suggest a more intricate relationship between the exocrine and endocrine, which may impact pancreatic growth and health. Additionally, …
Page 1 of 25