Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 65 for “"crossovers"”.
-
Genetic algorithms for the traveling salesman problem using edge assembly crossovers
The central issue in creating new genetic algorithms is the algorithm's crossover method. My focus is on a particular crossover known as the Edge Assembly Crossover, or EAX, by Nagata and Kobayashi. The basics of a what make up a genetic algorithm is reviewed. The traveling salesman problem is …
-
Iron spin crossovers at high pressures and temperatures and their effects on materials relevant tot he Earth’s lower mantle and core
… This cumulative thesis investigates Fe spin crossovers in iron-containing magnesium aluminum silicates, iron-bearing silicate glasses, the iron carbide Fe3C and the effect of Fe spin crossovers on the Fe/Mg partitioning between perovskite and ferropericlase in pyrolitic model system of the …
-
Cross Over and Duality. Murakami’s Integration of the Fantastical into the Ordinary
… This essay explores the different types of crossovers and dualities within Haruki Murakami’s novel, Kafka on the Shore. The novel’s narrative interchanges between a fifteen-year-old runaway who calls himself Kafka and a senile old man by the name of Nakata. The novel is set in modern day …
-
The Role of Arabidopsis thaliana Mismatch Repair Proteins in Meiotic Recombination
… have demonstrated roles in repressing meiotic crossovers in hybrid plants. To further investigate the meiotic function of MMR genome-wide, I generated a series of msh2 mutant introgression lines in three different genetic backgrounds – Ct-1, Ler-0 and CLC – which have varying patterns and …
-
ATM plays multiple roles in crossover regulation during mouse spermatogenesis
… in juvenile mice that exhibit reduced crossovers, referred to as the juvenile paternal age defect. During meiosis, ATM is known to negatively regulate SPO11-generated DNA double-strand breaks (DSBs). In mice, complete loss of ATM causes spermatocyte apoptosis during mid-prophase I, …
-
Identifying natural modifiers of meiotic crossover frequency in Arabidopsis thaliana
… undergo reciprocal genetic exchange, producing crossovers. This generates genetic diversity and is required for balanced homolog segregation. Despite the critical functions of crossovers, their frequency and distribution varies extensively within and between species. This crossover variation can …
-
The role of Arabidopsis thaliana heterochromatin component H2A.W in meiotic recombination
… exchange genetic information, also called crossovers. Crossovers break the linkage between genes and create new combinations of alleles which are inherited in the offspring population. Meiotic crossover events can be beneficial to plant breeding programmes, because they facilitate the …
-
The Role of Epigenetics in the Regulation of Meiotic Recombination in Triticum aestivum and Arabidopsis thaliana
… suppressed regions of the genome. Remodelling of crossovers to cold regions is of particular interest to crop breeders, who seek to unlock genomic regions to crossovers to identify novel, beneficial allelic combinations. To further characterize the meiotic recombination landscape in bread wheat, I …
-
Investigating the control of pairing and crossover formation in meiosis of Arabidopsis thaliana
… In Arabidopsis, ~10% of DSBs are repaired as crossovers, which are reciprocal exchanges of DNA between homologues. These physical connections ensure the correct segregation of chromosomes and generate genetic diversity. The remainder are processed as non-crossovers, important for pairing and …
-
Single-crossover recombination and ancestral recombination trees
… in discrete time, allowing only for single-crossovers, is studied extensively for the first time. We elaborate the underlying mathematical structure of the discrete-time process by providing a systematic approach that exploits the inherent (multi)linear and combinatorial structure of the …
-
Satellite borne radar altimetry : empirical orbit refinement and ocean signal recovery techniques
… by examination of single and dual satellite crossovers, with a view to identifying the extent of any signal aliasing: either by removal of long wavelength ocean signals or introduction of additional error signals. From these studies, it was concluded that sinusoidal approximation of the …
-
A forward genetic screen to identify factors that control meiotic recombination in Arabidopsis thaliana
… across all eukaryotes, which may be repaired as crossovers. However, downstream regulators of recombination remain to be identified, including those with species-specific roles. To isolate crossover frequency modifiers I performed a high-throughput forward genetic screen using EMS mutagenesis of …
-
Nuclear Magnetic Resonance Studies of the High-Temperature Superconductors in the Normal and Superconducting States
… temperatures at 215K and 500K describing crossovers between different scaling regimes of the antiferromagnetic correlation length. In the superconducting mixed state of YBa2Cu3O7-delta we find evidence for an unconventional field dependence of the density of states at the Fermi level. This …
-
Higher Order Chromosome Organization and Recombination Dynamics of Meiotic Prophase I In Mouse Spermatocytes
… recombination (HR). HR produces either crossovers, which result in the exchange of flanking markers between homologs, or noncrossovers, which are short regions ofgene conversion to the donor genotype. Crossover formation is critical for proper chromosome segregation and crossovers arise …
-
Discovery of a novel meiotic E3 ubiquitin ligase by characterisation of the barley desynaptic mutant <i>DES12.W</i>
… shown to have a skewed distribution of meiotic crossovers towards the telomeric ends of the chromosomes. We, and others, hypothesise that this must affect breeding progress because natural variation in interstitially located genes cannot be easily accessed. In order to better understand this …
-
Genetic strategies to manipulate meiotic recombination in Arabidopsis thaliana
… meiotic DNA DSBs that normally mature into crossovers. Instead, TALFokI nucleases (TALENs) were expressed from meiotic promoters in order to generate exogenous DSBs at sites determined by the DNA binding specificity of the TAL repeat domains. The project succeeded in transforming TALENs into …
-
Magnetoresistance and Thermoelectricity in Quasi-Low Dimensional Semimetals
… which can be understood as 1D to 2D crossovers of quasiparticle motion.
-
Soft Self-assembly and Densest Packings in Colloidal Models
… formally do not exist, marked structural crossovers can nonetheless be observed. Over the range σ ≤ D ≤ 2.82σ, we find in simulations that structural crossovers echo the structural changes to the densest packing sequence. We also observe that the out-of-equilibrium self-assembly depends on …
-
Human common fragile site FRA16D flexibility peak is not a strong mitotic: Recombination hotspot in <i>saccharomyces cerevisiae</i>
… mitotic recombination events, such as reciprocal crossovers (RCOs), break-induced replication (BIR), and chromosome loss. Overall, Flex1 does not appear to act as a hotspot for mitotic recombination. Contextual features may be more important factors in the instability of FRA16D.</p>
-
Epic Search for the Perfect Partner: MutSgamma Promotes Efficient Meiotic Recombination and Homolog Pairing in Mouse Spermatocytes
… of DNA repair by homologous recombination called crossovers, which involve a reciprocal exchange of homolog arms. However, before a crossover can be made, the homologs first have to come together and align along their lengths. This is a process called pairing. In humans and mice, among other …
Page 1 of 4