Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 180 for “"crosslinks"”.
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Repair of DNA-protein crosslinks in mammalian cells
… used to study the repair of DNA-protein crosslinks in mammalian cells. DNA-protein crosslinks (DPCs) are bulky lesions which disrupt important cell processes such as transcription and replication. They are formed by endogenous molecules such as formaldehyde and exogenous damaging agents …
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Biosynthetic and bioinformatic investigation of RiPPs with radical SAM-installed crosslinks
… the rSAM DarE to contain a fused ether and C-C crosslinks. Despite significant work in the field, there had been little investigation on DarE with respect to substrate scope and differential ether vs C-C crosslink formation. Therefore, we investigated the enzymatic tolerance of DarE towards the …
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Toward Real-time Earth Observation with Satellite Constellation Crosslinks and Propulsion
The development of remote sensing small satellite constellations has created the potential for high-resolution Earth-observation data to reach end users faster. This work investigates how propulsion and intersatellite links enable constellations to continuously collect and deliver data faster than …
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Engineering mechanical dissipation in solid poly(ethylene glycol) hydrogels with bio-inspired metal-coordinate crosslinks
… reversible network via metal ion coordinated crosslinks. Using rheometry, we study the contribution of the metal-coordinate network to the bulk gels mechanics and find that we can control both the amplitude and the frequency of peak mechanical dissipation with the histidine: metal ion ratio …
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Molecular Dynamics and Mechanical Behavior of Collagen Type I and its Lysine/Hydroxylysine-derived Crosslinks
… presence of inter-molecular, covalent, enzymatic crosslinks. There are several different types of these crosslinks; their composition is tissue-specific and dependent upon factors such as age and health. Furthermore, these enzymatic crosslinks tend to form specifically at amino/N- and …
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A study of the formation of interstrand and intrastrand crosslinks through abasic site and cleaved abasic site chemistry
… subsequent damages such as interstrand crosslinks or strand cleavage can arise. While numerous studies have been conducted on crosslinks and strand cleavage, there is still much unknown information that warrants further investigation. This dissertation will use the tools of bio-organic …
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Defining the role of endonuclease VIII-like 1 and 3 in the repair of interstrand crosslinks in cancer cells
… involved in the repair of DNA interstrand crosslinks (ICLs). More recently, two DNA glycosylases (endonuclease VIII – like 1 & 3 [NEIL1 & NEIL3]) that excise oxidised bases from DNA, thus initiating base excision repair, have been found to participate in the resolution of psoralen induced …
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Understanding of Intrinsic Sources of DNA Damage that Drive Human Disease: A Foray into the Study of DNA Interstrand Crosslinks and Genome-Embedded Ribonucleotides
… types of endogenous DNA damage: 1) interstrand crosslinks (ICLs) formed by DNA damaging aldehydes and 2) genome-embedded ribonucleotides. The clinical pathologies arising in the setting of the improper removal or repair of ICLs or genome-embedded ribonucleotides are diverse. A failure to remove …
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A PROPOSED NEW INTERNAL STANDARD FOR FREE, GLYCOSYLATED AND TOTAL PYRIDINIUM CROSSLINKS QUANTIFICATION IN HEALTHY WOMEN AND CHILDREN URINE: VALIDATION OF AN HPLC-FLUORESCENCE METHOD
… changing in urine concentrations of pyridinium crosslinks is usually measured. Pyridinium crosslinks are generally referred to the chemical compounds pyridinoline (Pyr) and deoxypyridinoline (D-Pyr), both considered specific markers of skeletal collagen degradation. They are released into the …
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Fatigue in rubber vulcanisates
… the destruction and reformation of polysulphide crosslinks. The magnitude of the effect was dependent upon the degree of extension and showed a maximum at extensions corresponding to the onset of stress-induced crystallisation. The incorporation of a reinforcing filler, HAF-carbon black, …
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Molecular mechanisms of the carcinogen chromium(VI)-induced DNA-protein crosslinking in cultured intact human cells
… we hypothesized that Cr(VI)-induced DNA-protein crosslinks may, in part, be due to generation of active oxygen species following the intracellular reduction of Cr(V1) and that antioxidants may ameliorate the genotoxic and carcinogenic effects of Cr(VI). We proposed to test our hypothesis with the …
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Studien zur Quervernetzung von Milchproteinen und zur Bildung individueller Crosslink-Aminosäuren
… um in der Folge den Anteil von unbekannten Crosslinks für die analysierten Lebensmittel bestimmen zu können. Die Identifizierung dieser vorhandenen, jedoch strukturell unbekannten Crosslinks ist ein weiteres Ziel der vorliegenden Untersuchungen. Hierbei richtet sich das Interesse vor allem …
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Strain-induced crystallization of crosslinked polyethylene
… samples with different amounts of chemical crosslinks and physical trapped entanglements. For experiments in the dry state, the sample was surrounded by silicon oil while in the swollen state experiments the sample was swollen in xylene. Samples were drawn to different draw ratios (1.2 …
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Effects of type-I collagen fractional composition and pyridinium crosslink content on cortical bone strength in the human femur
… crosslink content, or changes in the ratio of crosslinks to total collagen may also occur. The present study investigated (1) type-I collagen content in cortical bone from the human femur, (2) the mature, non-reducible pyridinium crosslink content of this bone, and (3) assessed the potential …
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Designing dynamic mechanics in self-healing nanocomposite hydrogels
… made to design polymer networks with transient crosslinks, which lays the foundation for synthetic self-healing hydrogels. Towards the development of stronger and faster self-healing hydrogels, understanding and controlling the gel network dynamics is of critical importance, since it provides …
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The Vulcanisation of Elastomers with Bis (Dialkyl) Thiophosphoryl Disulphides
… structure consists of polyand disulphidic crosslinks at early stages of cure, simplifying at optimum cure to monosulphidic crosslinks. Pendent accelerator groups bound to the rubber molecule form at early stages of cure, but are subsequently replaced by cyclic sulphidic groups. The good …
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Investigating the early events in proteasome assembly
… across itself. We were also able to detect α1-α1 crosslinks in high molecular weight complexes that are formed when α7 and α1 are co-expressed, and when α6, α7 and α1 are co-expressed in E. coli. The fact that we able to observe α1-α1 crosslinks in higher order structures that form whenever α7 and …
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Probabilistic methods for systems engineering with application to nanosatellite laser communications
… constellations with and without lasercom crosslinks: two ground stations vs. nine ground stations with (i and ii) lasercom and (iii and iv) X-band, and (v) UHF with one ground station. For example, we find that a 30-satellite Walker delta constellation of 6U satellites with an optical …
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EXPERIMENTAL STUDIES OF THE MECHANICAL BEHAVIOR OF A PVA DUAL-CROSSLINK HYDROGEL
… chemical (permanent) and physical (transient) crosslinks. The chemical crosslinks remain attached during loading while the physical crosslinks can break and reform, leading to the viscoelasticity. This material serves as a model system for understanding the behavior of such materials. Firstly, …
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