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Showing 1 to 20 of 51 for “"crosslinkers"”.
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Design of PolyMOCs and the synthesis of crosslinkers for the BASP platform
… (MMs) with varying anchor groups and crosslinkers that are stimuli-sensitive for the brush-arm star polymer (BASP) drug delivery platform. Variation of MM anchor groups modifies the rate of propagation of ring-opening metastasis polymerization (ROMP), while the design of crosslinkers …
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Design, synthesis, and exploration of a chimeric antioxidant and new crosslinkers for molecular imprinting
The improvement and utility of crosslinkers are important topics of molecular imprinting. Crosslinker significance is evident when molecularly imprinted polymer (MIP) composition related to performance as separation media is examined. Crosslinkers account for the bulk of MIP formulations made …
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Application of Genetically-Encoded Photoactivatable Crosslinkers to Map Ligand-Binding Sites on G Protein-Coupled Receptors
<p>G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce biological signals. Although GPCRs represent the largest class of targets for therapeutic agents, ligand-binding sites have been precisely defined for only a small percentage of the …
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Mass spectrometry of crosslinked peptides
… peptides crosslinked with the most commonly used crosslinkers BS3 (bissulfosuccinimidyl suberate) and DSS (disuccinimidyl suberate). We show that the choice of fragmentation parameters greatly impacts the number of reliably identifiable crosslinks. The most significant factors impacting the …
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Design and development of Brush-Arm Star Polymers for applications in drug delivery
… a variety of functional macromonomers and crosslinkers to use in BASP synthesis. For example, drug-loaded doxorubicin macromonomers were synthesized that could release free doxorubicin under a light stimuli or by hydrolysis. Crosslinkers were designed to facilitate BASP degradation, and …
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Formulation of Biodegradable Polysaccharide Blend as Replacement of Single-use Plastics
… plastics, as well as compare the introduction of crosslinkers and their enhancement. The fabricated films with or without crosslinkers were tested to determine their mechanical and thermal properties, anti-bacterial activity, water swelling, and soil degradation. A medical-grade plastic barrier …
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High fracture toughness and high modules silicone resins
… silicon vinyls and low molecular weight silane crosslinkers containing silicone hydrides. The resin is cured by hydrosilylation between the two. Intrinsic toughening improves the plasticity and rigidity of the resin by choices of crosslinkers and polyphenylsilsesquioxane oligomers. The …
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A 'Toolkit' of Small Molecules for Polymer Assembly and Post-Synthetic Modification Using 'Click' and Photoactive Chemistries
… homobifunctional exogenous photocrosslinkers that extend upon previous work from our group. Additionally, a first-generation crosslinker is used to core-crosslink micellar aggregates of block copolymers. Chapter 3 describes the design, synthesis, and implementation of a …
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Step-growth thiol-ene photopolymerization to form degradable, cytocompatible and multi-structural hydrogels
… and di-thiol containing molecules as the crosslinkers to form chemically crosslinked hydrogels. While the gelation mechanism was well-described in the literature, the network properties and degradation behaviors of these hydrogels have not been fully characterized. In addition, existing …
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Silicone resins and their composites
… resin is substantial and also depends on the crosslinkers used. Generally the maximum stress and flexural modulus decrease with temperature, and the dependence upon crosslinkers in addition cure resin is obvious. Fracture toughness data of addition cure silicone resins have a peaking behavior …
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Design of biopolymer-based networks with defined molecular architecture
… gelatin was reacted with four different diazide crosslinkers above its sol-gel transition to suppress the formation of triple helices. By variation of the crosslinking density and the crosslinker flexibility, the swelling (Q: 150-470 vol.-%;) and the Young’s and shear moduli (E: 50 kPa - 635 kPa, …
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Developing New Methodologies for Crosslinked Polymeric Nanostructure Syntheses, Chemoselective Modifications, and Applications as Imaging and Delivery Agents
… pyrazine-based chromophores were used as crosslinkers to probe directly their incorporation efficiencies into the shells of block copolymer micelles, which further determined the actual crosslinking extents ─ a critical factor for developing SCKs as PET imaging agents. The micelles were …
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Chemical Tools for Exploring Metabolite Interactions with Nuclear Receptors and Beyond
… proteins, whereas functionalization with photo-crosslinkers enables non-covalent metabolite–protein interactions to be captured. While we and many others have employed this approach to different metabolites and synthetic ligands, the installation of bio-orthogonal detection tags and …
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Effect of chemical structure and crosslinking density on the thermo-mechanical properties and toughness of (meth)acrylate shape-memory polymer networks
… varying sidegroup structure and multi-functional crosslinkers with varying mole fraction and functionality. Fundamental trends are established between the network chemical structure, crosslink density, glass transition temperature, rubbery modulus, failure strain, and toughness. The glass …
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Covalent end-immobilization of oligonucleotides onto solid surfaces
… surface by hybridization. Photolysis of psoralen crosslinkers covalently immobilized the dsDNA molecules to the oligo surface. The covalently end-attached dsDNA formed brush-like structures where the dsDNA strand could react under conditions resembling the natural solution-state found in vivo. …
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Synthesis and Characterization of Crystalline Assemblies of Functionalized Hydrogel Nanoparticles
… The HPC nanoparticles can be potential using as crosslinkers to increase the hydrogels mechanical properties, such as high transparency and rapid swelling/de-swelling kinetics. The central idea is to prepare colloidal particles containing C=C bonds and to use them as monomers - vinylparticles, to …
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Polyacrylamide and its derivatives for oil recovery
… viscosity and gelling ability in the presence of crosslinkers, polyacrylamides has become the primarily selection for polymer flooding and gel treatment agent in enhanced oil recovery. Recent developments, performance, applications and limitations of polyacrylamides and its derivatives, including …
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Synthesis and Properties of Chemically Modified Carbon Nanotubes
… the pyridine modified SWNTs were able to act as crosslinkers and hydrogen bond to poly(acrylic acid) to form SWNT hydrogels. The indolizine modified SWNTs, emitted blue light when excited ca. 330 nm, were capable of sensing 4-nitrophenol, 3-nitrophenol, 2-nitrophenol, 2-nitrosotoluene and …
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Air-gap sacrificial materials by initiated chemical vapor deposition
… possible combination of twenty monomers and four crosslinkers. P(npMA-co-EGDA) was deposited onto substrates using initiated chemical vapor deposition (iCVD) technique. Spectroscopic data showed the effective incorporation of both components in the copolymer and the integrity of repeating units …
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Computational methods and machine learning for crosslinking mass spectrometry data analysis
… Without the use of isotope-labeled or cleavable crosslinkers, applying a standard crosslinking approach using homobifunctional NHS-ester crosslinker reagents, an exhaustive peptide identification strategy becomes quickly unfeasible because of the dynamic explosion of the search space. Therefore, …
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