Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"crossbridge"”.
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Studies on actomyosin crossbridge flexibility using a new single molecule assay.
Several key flexure sites exist in the muscle crossbridge including the actomyosin binding site which play important roles in the actomyosin crossbridge cycle. To distinguish between these sources of flexibility, a new single molecule assay was developed to observe the swiveling of rod about a …
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Effects of the MYH7 R369Q Dilated Cardiomyopathy-causing Mutation on Myosin Crossbridge Kinetics and Cardiomyocyte Contractility
… to investigate its effect on the myosin crossbridge cycle kinetics and cell contractility. The rate of ATP binding to isolated myofibrils, as measured using the stopped-flow technique, was observed to be slower for the R369Q myosin variant. As contractility is driven by transient rise of …
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Nuove osservazioni sulla biomeccanica dell’uretere umano
… ureter are attributable to differences in myosin crossbridge interactions. Classic mechanical, kinetic and energetic parameters derived from the tension-velocity relationship were studied in ureteral smooth muscle strips oriented longitudinally and circularly from abdominal and pelvic human ureter …
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Finding analogies in semantic networks using the singular value decomposition
We present CROSSBRIDGE, an algorithm for finding analogies in large, sparse semantic networks. We treat analogies as comparisons between domains of knowledge. A domain is a small semantic network, i.e., a set of concepts and binary relations between concepts. We treat our knowledge base (the large …
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Thick filament regulation of myocardial contraction
… regulates myocardial contractility by limiting crossbridge cycling. We also examined the effects of SL on mechanical properties in rat skinned cardiac myocytes containing either [alpha]-MyHC or [beta]-MyHC. Peak absolute and normalized loaded shortening velocity and power output was decreased at …
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A FRET Investigation into Molecular Mechanisms of Cardiac Troponin Activation in Reconstituted Thin Filaments
… regulates actin and myosin interactions (crossbridge formation) by facilitating the release of two troponin I (TnI) actin binding sites at high Ca2+, the inhibitory region (IR) and the second actin binding site (SABS). The mechanism to remove TnI crossbridge inhibition is not well …
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Stretch-Dependant Tonic Force Maintenance in Rabbit Epigastric Artery
… Ca2+, myosin light chain (MLC) phosphorylation, crossbridge cycling rates and force increase to high levels, but with time, force is maintained while all other parameters of muscle activation fall to low levels. Thus, contraction is divided temporally into early (phasic) and late (tonic) phases, …
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Construction of plasmid-based expression and secretion vectors and study of the immobilization of proteins on the surface of Bacillus subtilis cells
… of the polypeptide chain to the peptide crossbridge linking the peptidoglycan strands in a transpeptidation reaction. B. subtilis has been reported to code for two putative sortases, YhcS and YwpE, but the sorting sequences recognized by them are yet unknown. To be able to immobilize …
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Structural Mechanisms of F-actin Mechanochemical Regulation and Flexible Network Assembly
… and heterogeneity analysis revealed substantial crossbridge flexibility which mediates crosslinking helical actin filaments into hexagonal bundles with mismatched symmetry. I also adapted my neural network denoising approach to analyze cryo-electron tomograms of fascin-bundled F-actin. This …