Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"cross-species comparison"”.
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Computational Analysis of Gene Expression Regulation from Cross Species Comparison to Single Cell Resolution
… data sets are available from diverse species. This trend enables us to perform comparative transcriptome analysis that identifies conserved or diverged gene expression responses across species using transcriptome data. The goal of this dissertation is to develop and apply approaches of …
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Computational genomics : mapping, comparison, and annotation of genomes
… sequence information, and ultimately study, cross-species comparison, and annotation of finished genomic sequence. We present applications of computational techniques to the above areas: (1) In relation to the early stages of a genome project, we address physical mapping, and we present …
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Therapeutic Potential of Protein Kinases and Their Downstream Targets Following Traumatic Cervical Spinal Cord Injury
… traumatic cervical SCI. First, a comparative cross-species transcriptional and genomic analysis identified molecular pathways with great therapeutic potential and translational relevance. As these molecular targets were predominantly kinase-related, the subsequent experiments were aimed to …
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Fine mapping studies of quantitative trait loci for baseline platelet count in mice and humans
… trait loci previously identified in a murine F2 cross, of which two (Pltct1 and Pltct2) had been found to reach genome-wide statistical significance. Fine mapping was attempted by three independent approaches. First, a human association study for platelet count was performed, and a cross-species …
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ACME and SPLiT-seq: Quantitative and evolutionary single-cell transcriptomics in planarians
… single-cell atlases for the planarian species Schmidtea mediterranea and Dugesia japonica. Later, I use the same pipeline in a single-cell RNA interference study, in S. mediterranea, to describe and quantify the effects of the hnf4 knockdown at tissue-resolution. Our results reveal …
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Feto-placental vascular structure and function: comparison of within and between species variations
… This thesis is motivated by a need to understand species differences, as despite promising therapies for pregnancy complications in animal models, clinical effectiveness is limited due to differences in placental structure and function between species. The first aim was to quantify the vascular …
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Integration and analysis of protein evolutionary relationships and small molecule bioactivity data
… potency between homologous proteins within and across species. Potency differences between related proteins are a useful indicator of small molecule specificity. Specificity is an early milestone for most drug discovery projects as it allows for the manipulation of a desired process in a targeted …
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Transcriptomic Signatures of Projection Class Neurons for Vocal Control
… birds and five times in mammals. Vocal learning species exhibit an underlying convergence in brain circuitry, including a direct, forebrain-to-brainstem projection critical for the motor production of learned vocalizations. The remarkable convergence in fore brain vocal circuitry is associated …
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Quantifying the pro- and antimutagenic roles of DNA damage and repair
… the mutational signatures of genotoxins across multiple genetic backgrounds. Importantly, the mutagenic contributions of genetic and mutagenic factors can vary dev pending on the DNA repair components available: over 35% of genotoxin-knockout combinations demonstrated a measurable effect …
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Investigating Maladaptive Habit Formation and Threat Influences in Obsessive-Compulsive Disorder
… results in challenges in comparing findings across studies and has implications for the translational relevance of PIT between species. Rodent PIT studies reveal insights into the acquisition and consolidation of reward-based learning in humans, therefore a cross-species comparison to optimise …
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Development and implementation of ontology-based systems for mammalian gene expression profiling
… the expression profile of an entire genome across a large collection of experiments derived from different expression sources. In this dissertation I describe the development of the developmental human and mouse eVOC ontologies and demonstrate the ontologies by identifying genes showing a …