Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 121 for “"cross-species"”.
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Cross-Species Evolution of New AAV Variants
… at least in part, by differences in AAV biology across animal species. Here, we present a broadly applicable, cross-species evolution approach to tackle this challenge. Specifically, I iteratively cycled AAV libraries administered intravenously and amplified isolates from CNS tissue in pigs, mice, …
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A cross-species network science approach to childhood adversity
The brain is an adaptive organ whose development is responsive to its early-life environment. This means that early experiences shape the biological substrates of lifelong health and well-being. Indeed, exposure to significant adversity in childhood increases the risk of a range of cognitive and …
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Pathogenesis and Cross-species Infection of Hepatitis E Virus
… 3 and 4 infect humans and several other animal species including pigs and rabbits. An ever-expanding host range of genetically-diversified strains of HEV now include bat, fish, rat, ferret, moose, wild boar, mongoose, deer, and camel. Additionally, the ruminant species goats, sheep, and cattle …
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Integrating Spatial Transcriptomics Data for Cross-Species Molecular Region Comparison
Comparative analysis of brain patterns across species can advance understanding of different biological processes and functions. Spatially resolved transcriptomics (SRT) technologies present the ability to measure gene expression of single cells within tissues, enabling the detection of unique …
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Computational Analysis and Network-based Modeling of Cross-Species Transmissions
… dominant cause of emerging infectious diseases.Cross-species transmission (CST) risks are accelerated by climate change, which alters animal habitats and aggregates new combinations of host species at high population density and elevations. Modeling CST dynamics is essential in ecology and …
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Cross-Species Infection and Characterization of Avian Hepatitis E Virus
… To determine if avian HEV can infect across species, one-week old SPF turkeys were intravenously inoculated each with 10<sup>4.5</sup>(CID₅₀) of avian HEV. The inoculated turkeys seroconverted to avian HEV antibodies at 4-8 weeks postinoculation (WPI). Viremia was detected at 2-6 WPI, …
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Factors affecting replication and cross-species transmission of feline immunodeficiency virus
In order to successfully invade a new species, lentiviruses must overcome restriction factors, dominant blocks to replication, and be able to make use of available host factors such as entry receptors for replication. Human immunodeficiency virus (HIV-1) infection is blocked at a post-entry stage …
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Cross-species microarray analysis of limb development in the bat, Miniopterus natalensis
… reproduction and development of an African bat species, Miniopterus natalensis, was characterised and three maternal features (mass, belly size and plasma progesterone levels) examined as potential predictors of embryonic stages of development. Belly palpitation was found to be a useful field …
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Reconstructing Cross-Species Ancestral Adeno-Associated Viruses for Enhanced Gene Therapy Delivery
… tropism can translate into suboptimal cross-species transduction efficiency and potential toxicity, complicating the clinical transition from animal model to humans. These challenges impede the use of naturally occurring AAVs for therapeutic gene delivery in many neurological …
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Cross-species single-cell transcriptomics and its applications in evolutionary and translational research
… techniques have been used to profile cells in species across the tree of life. The availability of single-cell data from a rich diversity of species presents an opportunity to compare gene expression, cell types and developmental programmes across organisms and interpret these transcriptomic …
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Cross-Species Translocation of mRNA from Host Plants into the Parasitic Plant Dodder
Dodders (Cuscuta spp.) are parasitic plants that live by tapping into the vascular tissue of a host plant. Contents of the host phloem translocate readily into the parasite, and shared plasmodesmata have been documented between host cortical cells and dodder searching hyphae. Dodder is known to …
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The Social Cognition of Domestic Dogs (Canis familiaris) During Cross-Species Interactions with Humans
… an impressive cognitive skillset within the species; however, little research is conducted in naturalistic settings. Thus, much of what is currently known about dog cognition comes from laboratory trials. This thesis explores the dog cognitive skillset, investigating their social cognition …
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Cross-species comparisons of the retrosplenial cortex in primates: Through time and neuropil space
… future thinking or planning, among non-human species. The retrosplenial cortex (Brodmann’s areas 29 and 30) plays a critical role in episodic memory, which is vital for MTT. Because MTT appears to be a uniquely human capacity, this region is of major interest for evolutionary studies. However, …
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A bioinformatic study on the feasibility of a cross-species proteomics analyses of mycobacteria
Includes abstract. Includes bibliographical references.
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Computational Analysis of Gene Expression Regulation from Cross Species Comparison to Single Cell Resolution
… data sets are available from diverse species. This trend enables us to perform comparative transcriptome analysis that identifies conserved or diverged gene expression responses across species using transcriptome data. The goal of this dissertation is to develop and apply approaches of …
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Foodborne Transmission and Molecular Mechanism of Cross-species Infection of Hepatitis E Virus (HEV)
… indicating that genotype 4 human HEVs can cross species barriers and infect pigs. To identify viral determinant(s) of species tropism, ORF2 alone or in combination with its adjacent 5′ junction region (JR) and 3′ non-coding region (NCR), were swapped between genotypes 1 and 4, 3 and 4, and …
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Identifying cross-species regimens for the treatment of rapid-growing and slow-growing nontuberculous Mycobacterium pulmonary infections
… between Mycobacterium tuberculosis (TB) and NTM species, TB standard-of-care (SoC) drugs were evaluated for repurposing to develop regimens with activity across diverse NTM pathogens. Comparative genomics using the Distilled Refined Annotation of Metabolism (DRAM) tool demonstrated that …
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Role of endogenous retrovirus in control of feline leukemia virus infection and implications for cross species transmission
… in Florida panthers (Puma concolor coryi), a species that lacks endogenous FeLV. Our phylogenetic analysis of the contemporary FeLV outbreak has further implicated domestic cats (Felis catus) as the origin of FeLV infections in wild felids. Furthermore, we detected a recombinant oncogenic …
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