Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"cross-resistance"”.
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Cross resistance to organophosphorus compounds in malathion- and diazinon- resistant strains of the German cockroach
… of the same species reveals that development of resistance to malathion in this species is highly specific imparting no effective cross resistance to any of the other seven compounds evaluated. Selection with diazinon induces a low level of tolerance to all the organophosphates studied, but there …
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Growth Analyses and Patterns of Cross-Resistance in Four Imidazolinone-Resistant Smooth Pigweed (Amaranthus hybridus) Populations
… herbicides, (2) determine the mechanism of resistance, and (3) evaluate the relative growth and competitiveness of each population. Field studies were conducted in 1996 near Marion, MD, in a field with a history of repeated imazaquin use. Smooth pigweed control with IMI herbicides was < 8 …
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Understanding Bacterial Resistance and Dissemination: The Impact of Biocide Priming
… the expression and dissemination of antibiotic resistance genes. Aims: To investigate the priming effects of sub-inhibitory concentrations of biocides on antibiotic resistance in bacteria and to understand the resistance mechanisms activated by these effects. Methodology: Escherichia coli, …
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Statistical methods and models for analyzing sugarcane (Saccharum species hybrids) plant breeding data
… genotypes resistant to one species would provide resistance to the other (cross-resistance). The objectives of the study were to identify statistical methods to evaluate family yield potential and repeatability, enhance seedling selection for yield, analyze advanced variety trials data and prove …
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Antibiotic and biocide resistance in Salmonella enterica and Escherichia coli 0157
Bacterial resistance to antibiotics and biocides is a prevalent problem, which may be exacerbated by the commonplace and often unnecessary inclusion of biocides into domestic products. Addition of antimicrobials, to domestic disinfectants has raised concern about promoting microbial resistance and …
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Studies on the outer membrane of Pseudomonas aeruginosa and associated resistance properties
… based upon successful structures. Development of resistance to antibacterial agents following long-term exposure of P. aeruginosa to BKC was also investigated, examining cross-resistance to clinically relevant antibiotics and determining mechanisms of resistance. In this study over 50 compounds …
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Characterization and Management of Acetolactate Synthase Inhibiting Herbicide Resistant Mouse-Ear Cress (Arabidopsis thaliana) in Winter Wheat
… acetolactate synthase (ALS) inhibiting herbicide resistance in the model plant, mouse-ear cress, was reported in winter wheat fields in Westmoreland County, Virginia. A putative resistant (R) mouse-ear population was assessed for ALS resistance relative to a putative susceptible (S) and a …
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Folate transport and drug resistance in the African Trypanosome
… the knowledge of the mechanism of action and resistance of antifolate drugs in African trypanosomes with a specific focus on transport mechanisms. A media deficient in folate and thymidine was established which enabled the assessment of their modulation on antifolate in vitro potencies and …
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Nitroaromatic pro-drug activation and resistance in the African trypanosome
… the only, mechanism that may lead to nitrodrug resistance. Furthermore, in the bloodstream form of T. brucei, resistance was relatively easy to select for nifurtimox, with no concurrent loss of virulence and at clinically relevant levels. More worryingly, nifurtimox resistance led to a decreased …
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Investigation of Dual Stage Acridones as a Potent Malaria Treatment
… T13, we selected stable chemotype I acridone resistance by using multiple rounds of 24 hour intermittent pressure and incremental continuous pressure. Control parasites exhibited an IC<sub>50</sub> value of ~40 nM T13, while cloned resistant parasite lines showed IC<sub>50</sub> values of …
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ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΤΗΣ ΑΝΤΟΧΗΣ ΤΩΝ ΨΕΥΔΟΜΟΝΑΔΩΝ ΣΤΑ ΑΝΤΙΒΙΟΤΙΚΑ
… BY 14 SELECTED PSEUDOMONAS STRAINS, WITH HIGH CROSS-RESISTANCE TO CARBENICILLIN AND CEFSULODIN, WAS PERFORMED BY THE MACROIODOMETRIC METHOD. THE TYPE OF ENZYME PRODUCED WAS DETERMINED BY THE ISOELECTRIC FOCUSING METHOD. (SHORTENED)
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Characterization and transcriptomic profiling of Arabidopsis thaliana under cellulose biosynthesis inhibitor treatment
… length clustering showed similar responses and cross-resistance patterns based on mutation location. A 3-D homology protein model of the cellulose synthases (CESAs) was generated to display our alleles. This model contradicted previous models and predicted a protein with seven-membrane spanning …
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Methoprene as a poultry feed additive for house fly control
… causes of these problems were an existing cross-resistance to methoprene in the field strains followed by an induction in resistance resulting from the continuous exposure to methoprene.
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Phenotypic and molecular antifungal susceptibility testing of yeast isolates from Pretoria
Antifungal drug resistance is a growing problem. Several mechanisms contribute to the development of resistance to antifungal agents. In South Africa, little is known about the antifungal susceptibility of local yeast isolates. The aim of this study was therefore to determine the antifungal …
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Putative phosphodiesterase inhibitors as potential new chemotherapies against African Trypanosomiasis
… toxicity, affordability and the emergence of resistance. The case for the generation of new potential chemotherapies is compelling and urgent. Phosphodiesterase (PDE) enzymes degrade the secondary signalling molecule cyclic adenosine monophosphate (cAMP) to AMP by hydrolysis, thereby …
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IN VITRO ΑΝΑΠΤΥΞΗ ΑΝΤΟΧΗΣ ΠΡΟΤΥΠΟΥ ΣΤΕΛΕΧΟΥΣ PSEUDOMONAS AERUGINOSA ΣΤΟ ΙΜΙΡΕΝΕΜ ΚΑΙ ΙΔΙΟΤΗΤΕΣ ΑΥΤΟΥ
… INDEPENDENT PROPERTIES. THIS TYPE OF IN VITRO RESISTANCE TO IMIPENEN AFFECTED GROWTH RATE, COLONY MORPHOLOGY, PIGMENT PRODUCTION, GROWTH OF 42 C AND GLUCOSE OXIDATION. BETA-LACTAMASE ASSAYS SHOWED THATTHE MOST LIKELY REASON FOR THE RESISTANCE WAS THE EXISTENCE OF AN INCREASE PERMEABILITY …
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Semi-synthesis and evaluation of fusidic acid derivatives as potential antituberculosis agents
… Although TB is curable, the ability to acquire resistance to various antibiotics by the Mtb organism is well known. The emergence and spread of multidrug resistance (MDR) and extremely drug resistance (XDR) Mtb strains, along with HIV/TB co-infections, has put TB control programmes in jeopardy, …
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Studies on the development of antimicrobial tolerance in monospecies and binary biofilms
… on its own can explain the development of resistance in biofilm cells. The practical implications of biofilm formation are that alternative control strategies must be devised both for testing the susceptibility of the organisms within the biofilm and treating the established biofilm to …
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Mechanisms of multidrug resistance in bladder cancer: the role of the nuclear membrane
Multidrug resistance (MDR) describes the phenomenon whereby cancer cells<br/>exposed to a single cytotoxic drug develop cross resistance to numerous other<br/>structurally unrelated chemotherapeutics. The development of MDR is a major<br/>cause of cancer chemotherapy treatment failure in all types …
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Forward genetic analysis of cellulose biosynthesis inhibitor resistance and wall hydrolysis sensitivity.
… plants. Mutations resulting in a high degree of resistance to isoxaben (ixr) or flupoxam (fxr) were attributed to single amino acid substitutions in primary wall CESAs. Twelve novel resistance alleles were isolated and no cross-resistance was observed. Point mutations were mostly clustered around …
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