Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"cross-protection"”.
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Cross-protection and Potential Animal Reservoir of the Hepatitis E Virus
… (administered intravenously). The protective and cross-protective abilities of these antigens were determined following swine genotype 3 challenge by evaluating both serum and fecal samples for HEV RNA using nested RT-PCR and IgG anti-HEV using ELISA. The results from these two studies have …
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Population oscillations, synchronization, and range expansion in a bacterial cross-protection mutualism
… that two Escherichia coli strains can form a cross-protection mutualism, protecting each other in the presence of two antibiotics (ampicillin and chloramphenicol) so that the coculture can survive in antibiotic concentrations that inhibit growth of either strain alone. Moreover, we find that …
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Cross-protection from St. Louis encephalitis virus and Usutu virus disease by human West Nile virus convalescent plasma in mice
… antibodies and heterotypic antibodies that can cross-neutralize other members of the JEV serocomplex group, such as USUV and SLEV. Therefore, cross-reactive epitopes can protect against heterologous virus challenges to varying extents, depending on the accessibility of the antibodies to the …
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Eltérő virulenciájú fitoplazma törzsek kölcsönhatásának szerepe a keresztvédettség kialakulásában = Interaction between phytoplasma strains of different virulence and its impact on the developement of cross protection
Napjainkban egyre nagyobb gazdasági károkat okoznak a fitoplazmák által előidézett megbetegedések mind lágyszárú-, mind fásszárú dísz- és haszonnövényeken. Habár a kórokozócsoportot már az 1900-as évek eleje óta kutatják, a molekuláris kimutatási módszerek elterjedésével csak a XX. század végére …
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Immune responses against recombinant poxvirus vaccines that express full-length lyssavirus glycoprotein genes
… animals, such as dogs, which indirectly infers protection to susceptible hosts, including man. Currently available vaccines present several disadvantages of use though, including issues of safety or doubtful stability. Safer but effective alternative vaccines that could be used in oral baits …
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Molecular modelling of the Streptococcus pneumoniae serogroup 6 capsular polysaccharide antigens
… 6B, 6C and 6D in an attempt to understand the cross protection seen within the group. The 6B saccharide has been included in the early conjugate vaccine (PCV-7), and has shown to elicit protection against the 6B as well as some cross-protection against 6A. 6A has since been included in the …
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Yellow Fever: Role of Heterologous Flavivirus Immunity on Urban Emergence
… virus infection, and to determine mechanisms of cross-protection. We utilized African and Brazilian YF strains and found that DENV-2 and ZIKV immunity significantly suppresses YFV viremia in mice but did not consistently protect against disease outcome. Cross-protection appears to be mediated …
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Immune Response of Swine to Porcine Reproductive and Respiratory Syndrome Virus: Laboratory and Field Studies
… to autogenous (endemic) PRRSv strains; comparing protection against autogenous and heterogenous strains to better understand cross protection; and discovering T cell epitopes of PRRSv, which will be useful for designing epitope driven vaccines.
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Influence of Physiological State, Prolonged Dry Storage, and Passage through Simulated Digestion on the Survival and Gene Expression of Salmonella enterica sv. Tennessee
… milk powder was not associated with increased cross-protection to gastric stress. Increased expression of stress response genes rpoS and otsB correlated with survival, indicating cross protection of low water activity and acid stress. Increased expression of virulence-associated genes was seen …
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Development and characterization of Shigella multiepitope fusion antigen (MEFA) for a broadly protective subunit vaccine against shigellosis with extended utility against enterotoxigenic Escherichia coli.
… vaccines for Shigella lies in achieving cross-protection among the diverse subspecies of Shigella. A vaccine candidate, “Shigella MEFA” was designed by applying the epitope- and structure-based multiepitope-fusion-antigen vaccinology platform (MEFA), which incorporated the immune-dominant …
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Cooperative behaviors in the evolution of antibiotic resistance
… two strains of Escherichia coli can form a cross-protection mutualism in a multi-drug environment containing the antibiotics ampicillin and chloramphenicol. In both experimental systems, I found that inactivation of antibiotics by resistant bacteria is an important cooperative behavior which …
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West Nile virus vaccination protects against Usutu virus disease in mice
… and USUV have been found in birds and humans across Europe. In vitro cross-neutralization of WNV and USUV has been modeled experimentally and been observed in clinical settings. The neutralizing antibody response generated against WNV has been studied extensively in mouse models; however, there …
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Chemical and conformational studies of bacterial cell surface polysaccharide repeating units
… in vaccines and play an important role in the protection against numerous diseases including meningococcal disease and shigellosis. This study is composed of two parts: a computational section, which investigates the capsular polysaccharide (CPS) repeating unit (RU) conformations of …
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Effects of heat and acid stress on bacterial populations of beef, and on susceptible and multi-antimicrobial resistant Salmonella isolated from beef
… and whether antimicrobial resistance provided cross-protection against low-pH or heat stress. Results of studies evaluating methods to improve microbiological quality of chilled beef carcasses, subprimal cuts, and fabrication table surfaces, suggested reduced antimicrobial efficacy (≤ 1 log …
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Molecular Characterization of Viruses Infecting Greenhouse Vegetables in Ontario
… to be used as attenuated CGMMV variants for cross protection against CGMMV.
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Characterization of the Burkholderia mallei ∆tonB Mutant and its Potential as a Backbone Attenuated Strain for Vaccine Development
… immunized with the B. mallei ∆tonB mutant. In a cross-protection study with Burkholderia pseudomallei, B. mallei ∆tonB mutant-immunized animals showed significant protection when evaluated in an acute inhalational melioidosis mouse model. While the wild-type was cleared in all the vaccination …
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Molecular modeling of bacterial polysaccharide antigens to inform future vaccine development
… vaccine strains in a multivalent vaccine cross-protect against non-vaccine strains. Detailed knowledge of antigen structure and conformation is required for vaccine components to be rationally selected. However, experimental methods may not be able to ascertain the conformations of …
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Molecular modeling studies of carbohydrate vaccine antigens: informing the future of vaccine design
… targets, this research aims to predict potential cross-reactivity and cross-protection, rationalize observed immunological reactivity, and provide valuable insights into key epitopes and mechanisms for antigen-antibody binding. The case studies encompass the following antigens: Haemophilus …
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Establishment and Improvement of Preclinical Murine Models of Severe Scrub Typhus to Define Immune Signatures and Pathogenic Mechanisms
… due to a variety of Ot strains with limited cross protection. However, little is understood about strain-specific virulence factors or host immune response. While there are many established murine models of scrub typhus, differences in route of infection, host resistance, and clinically …
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Intranasal Immunization of Pigs with Porcine Reproductive and Respiratory Syndrome Virus like Particles Plus 2’, 3’ –cGamp Vaccigrade™ Adjuvant Exacerbates Viremia After Virus Challenge
… Current PRRSV vaccines appear to provide limited cross-protection. A virus-like particles (VLPs) vaccine is made up of key PRRSV structural proteins, which could be cross protective among the different strains. We tested PRRSV VLPs as a vaccine candidate with a 2’, 3’-cGAMP VacciGradeTM adjuvant …
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