Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"cross-linking mass spectrometry"”.
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Large Scale Cross-Linking Mass Spectrometry as the Missing Link in the Systems Biology Toolbox
… sufficient detail, and in a generalisable way. Cross-linking mass spectrometry (XL-MS) performed on high complexity samples (such as entire organelles or cells) theoretically enables the large scale mapping and monitoring of protein structural conformations and PPI interfaces in native …
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Structural and Molecular Mechanisms of Centrosome Assembly and Strength
… understood. To answer such question, we use cross-linking mass spectrometry (XL-MS) to analyze PLK-1-potentiated multimerization of SPD-5, the main PCM scaffold protein in C. elegans. In the unassembled state, SPD-5 exhibits numerous intramolecular interactions that are eliminated after …
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Mechanistic Investigation into the Regulation of Amyloid Motifs in Tau Aggregation and Disease
… protein and synthetic peptide systems, cross-linking mass spectrometry, and cell models to investigate the biophysical mechanisms behind aggregation of the P301L/S and S320F mutants. We conclude that the aggregation prone 306VQIVYK311 motif forms metastable compact structures with its …
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Proteomic Characterisation of the mdx-4cv mouse model of Duchenne Muscular Dystrophy
… has employed label-free liquid chromatography mass spectrometry along with chemical cross-linking mass spectrometry to characterise alterations in protein abundance and protein interaction patterns, respectively, in the mdx-4cv animal model of Duchenne muscular dystrophy. Proteins of particular …