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Showing 1 to 20 of 46 for “"cross-couplings"”.
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Nickel-catalyzed cross-couplings of unactivated secondary and tertiary alkyl halides and photoinduced copper-mediated asymmetric C-N cross-couplings
… the development of two nickel-catalyzed Suzuki cross-coupling methodologies that employ alkyl halides as electrophiles. In Section 1.1, asymmetric [gamma]-alkylation relative to a carbonyl group is achieved via the stereoconvergent cross-coupling of racemic secondary [gamma]-chloroamides with …
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TRANSITION METAL CATALYZED CROSS-COUPLINGS OF ALKYL SULFONE ELECTROPHILES
… While their use as Csp2 electrophiles in cross-coupling dates to the early 1970’s, their potential as competent Csp3 electrophiles has not been recognized until recently. Our group has made significant contributions to the development of new cross-coupling methodologies utilizing alkyl …
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A LIGO Double Pendulum Suspension Prototype for Reducing Unwanted Cross-Couplings
… down the two interferometer arms. Unwanted cross-couplings between degrees of freedom in LIGO suspensions pose a large problem when trying to isolate their optics in the interferometer. This thesis provides an analysis of the effects of changing the wire geometry of a double pendulum as a …
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Design of a second generation MIDA boronate: iterating c(sp3) based Suzuki cross couplings
… other biomolecules, we have pioneered iterative cross coupling (ICC) as an analogous platform for small molecules. Enabled by both a building block based synthesis strategy and a general purification protocol, our group has designed and built a small molecule synthesizer. We have demonstrated the …
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Progress in nucleophilic catalysis and development of nickel-catalyzed cross-couplings of propargylic halides
… described. Chapter 2 discusses nickel-catalyzed cross-coupling reactions of secondary propargylic halides with a variety of organozinc nucleophiles. Section 2.2 describes progress toward an asymmetric alkylation reaction. In Section 2.3, the development of the first alkyl-alkyl …
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Nickel-catalyzed asymmetric cross-couplings of secondary allylic chlorides and planar-chiral compounds in asymmetric synthesis
… catalyzes regio- and enantioselective cross-couplings between racemic secondary allylic chlorides and readily available alkylzinc halides. This method is applied to generate two stereo centers in a formal total synthesis of fluvirucinine A1. In Part II, the use of planar-chiral …
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Nickel-catalyzed asymmetric cross-couplings of secondary alkyl electrophiles and photoinduced, copper-catalyzed C-N couplings
… of three nickel-catalyzed asymmetric Negishi cross-couplings of secondary alkyl electrophiles via a stereoconvergent process. In Section 1.1, asymmetric Negishi arylations and alkenylations of [alpha]-bromonitriles with arylzinc and alkenylzinc reagents are achieved using a …
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Synthetic Retinoids
… aromatic C-H borylations, Sonogashira cross-couplings and Suzuki-Miyaura cross-couplings for the synthesis of tolan-, and biaryl-based retinoids. Chapter four details the development and applications of new RhI catalyst precursors for the dehydrogenative borylation of unactivated …
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Development of organosilicon cross-coupling reaction
Use of palladium catalyzed cross-couplings have found widespread use in the pharmaceutical industry and there is a significant ongoing effort to either improve or devise new synthetic strategies to help build complex biologically active compounds. This is a study for advancing the use of silanols …
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Palladium-catalyzed C-N cross-coupling reactions toward the synthesis of drug-like molecules
… will focus particularly on palladium-catalyzed cross-couplings of amine-containing compounds with aryl halides. The scope of the BrettPhos precatalyst for the cross-coupling of ortho-substituted aryl iodides with amides is studied using substrates with a variety of functional groups. Due to …
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The Development of Asymmetric Palladium-Catalysed Transformations Using Chiral Sulfonated Phosphine Ligands
… additions and atroposelective Suzuki- Miyaura cross-couplings. For asymmetric palladium-catalysed allylic alkylations, high levels of enantioselectivity could be achieved with 1,3-diphenylallyl substrates and nucleophiles possessing one or more electron-withdrawing groups. A large ligand …
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METAL-CATALYSED CROSS-COUPLING REACTIONS OF NITROGEN HETEROCYCLES
… reactions then undergo palladium-catalysed C-C cross-couplings with aryl or heteroarylboronic acids under Suzuki-Miyaura conditions to provide a rapid entry to tris(hetero)aryl scaffolds comprising two or three N-heterocyclic rings. The sequential N-C and C-C couplings can be performed in a …
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COMPLEXES OF GROUP 10 METALS WITH NON-CLASSICAL AND THIOETHER-FUNCTIONALIZED N-HETEROCYCLIC CARBENE LIGANDS
… direct arylation of 1-methylpyrrole, Sonogashira cross-couplings, and the hydroamination of alkynes. The forth part describes the synthesis of thioether-functionalized NHC precursors, and the coordination chemistry of these NHCs with platinum(II), palladium(II) and nickel(II), and the catalytic …
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SYNTHESES AND METAL MEDIATED REACTION CHEMISTRY OF 2-SILYL-1,3-DIENES
… and subsequent Hiyama-Denmark and Negishi cross couplings to make highly substituted cyclohexenoids with controlled relative and absolute stereochemistries. Diterpenoids containing the clerodane carbon skeleton are prevalent as secondary metabolites. Synthetic approaches to the …
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Coupling reactions using flow-generated diazo compounds
… and ‘oxidative’ C(sp2)-C(sp3) cross-couplings. Finally, the fifth chapter describes the experimental procedures relevant for the results described in Chapters 2-4.
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A study of the detection efficiency of the LIGO interferometers to transient sources
… purposes. Their primary goal is to study the cross-couplings between the gravitational wave channel and the auxilary channels. They also allow us to benchmark the ability of our search method to extract the signal parameters, thereby validating a whole portion of the analysis pipeline. …
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ARYL-HETEROATOM CROSS-COUPLING WITH DUAL NICKEL/PHOTOCATALYST PROTOCOLS : THEORY, APPLICATIONS AND RECENT DEVELOPMENTS
… protocols to conduct aryl-heteroatom cross-coupling reactions is presented. Basic concepts of photocatalysis, including different relaxation pathways, the difference of singlet and triplet states, and parameters used to predict reactivity are first disclosed. The general components …
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Kinetic Studies of 6-Halopurine Nucleoside in SNAr Reactions; 6-(Azolyl, Alkylthio and Fluoro)-purine Nucleosides as Substrates for Suzuki Reactions
… for certain transition metal-catalyzed cross-coupling reactions. In chapter 2, we describe synthesis of protected 6-fluoro, 6-chloro, 6-bromo and 6-sulfonylpurine nucleosides. Comparisons among 6-fluoro-, 6-chloro-, 6-bromo, 6-iodo and 6-sulfonylpurine nucleosides for SNAr reactions with …
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IMPROVING THE SCOPE AND UNDERSTANDING OF THE SYMMETRIC AND ASYMMETRIC SUZUKI COUPLING REACTION
… into the Symmetric and Asymmetric Suzuki cross-coupling reaction have been described. A new reaction protocol has been developed in which isolated pre-activated sodium trihydroxyarylborate salts were employed as the organoboron coupling partner, resulting in a more convenient and …
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Palladium-Imidazolium Carbene Catalyzed Heck Coupling Reactions and Synthesis of a Novel Class of Fluoroanthracenylmethyl PTC Catalysts
… to be highly efficient for the Suzuki-Miyaura cross couplings. The most active bis-2,6- diisopropylphenyl dihydroimidazolium chloride ligand 1 in that series together with palladium acetate were employed as the catalyst, to efficiently catalyze the Heck coupling of aryl diazonium ions with …
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