Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"cristae"”.
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Estudo citoquímico de enzimas mitocondriais de Trypanosoma cruzi em culturas de tecido
… the host cell rnitochondria at the region of the cristae; and inner membrane. In the intracellular forms of the parasite the reaction also occurs at the cristae and inner rnembrane in all regions of the mitochondria. For the lipid pathway enzymes a Glycerophosphate Dehydrogenase and B …
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Mitochondrial Structure-Function in health and disease
… In these works, we investigate the role of cristae-shaping factors like cardiolipin in health and disease. In a series of studies, we tested the effects of the cell-permeable tetrapeptides, elamipretide and a postulated peptide, (arginine-tyrosine-lysine-phenylalanine; "RYKF"), on the …
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The Mitochondrial Fusion Protein, Optic Atrophy 1 (OPA1), Alters Cellular Metabolism to Support Cancer Cell Viability
… inner mitochondrial membrane GTPase, OPA1, is a cristae-organizing protein that directly organizes formation of the electron transport chain for oxidative phosphorylation and thereby further coordinates with the tricarboxylic acid (TCA) cycle. To study mitochondrial fusion as a target, we found …
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Investigating metabolic and mitochondrial adaptations triggered by blood flow during the endothelial-to-hematopoietic transition
… with immature mitochondria containing fewer cristae, as determined by electron microscopy. Force generated by blood flow stimulates mitochondrial protein translation, cristae formation, increased mitochondrial membrane potential, and oxidative phosphorylation. These adaptations can be …
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Morphological and histochemical observations of hepatic peroxisomes and lysosomes of rats after treatment with methylmercuric chloride, hydrogen peroxide and gamma radiation
… endoplasmic reticulum, loss of mitochondrial cristae and presence of polyribosomes and/or glycogen were observed at day 2. Seepage of hydrolytic enzymes from disrupted lysosomal membrane and persistence of polyribosomes or glycogen and dissolution of mitochondrial cristae were observed at day …
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TAp73 regulates mitochondrial dynamics through an OPA1 axis
… of the inner mitochondrial membrane and controls cristae remodelling, a process facilitating the execution of apoptosis. I have shown that TAp73 regulates OPA1 expression in TAp73-/- cell lines which were generated using CRISPR/Cas9 targeting. Concurrently, I show that disruption of this …
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Anti-apoptotic MCL-1 Localizes to the Mitochondrial Matrix and Couples Mitochondrial Fusion to Respiration
… ATP production, membrane potential, respiration, cristae ultrastructure, and maintenance of oligomeric ATP synthase. My results provide insight into how MCL-1's surprisingly diverse salutary functions may control the survival of both normal and cancer cells. </p>
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Role and regulation of mitochondrial permeability transition in cell death
… reticulum (ER) stress by remodeling the cristae junction (CJ). CEM cells were treated with the ER-stressor thapsigargin (THG) which led to cyclophilin-D-dependent mitochondrial release of the profusion GTPase Optic Atrophy 1 (OPA1), which controls CJ integrity, and cytochrome c leading to …
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Diverzita a evoluce anaerobních heteroloboseí
… probably possesses remnants of mitochondrial cristae. Creneidae are represented just by a single species, Creneis carolina, which displays unique cell structure and life cycle. Architecture of its flagellar apparatus is not readily comparable with any other eukaryotes and at least some …
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X-ray diffraction studies of muscle : observations on the anterior byssus retractor muscle of Mytilus edulis and the insect flight muscle from Sarcophaga bullata
… as suggesting an ordered arrangement of cristae, in the mitochondria from these muscles.
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Premature vascular senescence during diabetic retinopathy
… mass but, with alterations in mitochondrial cristae ultrastructure and decreased cellular bioenergetics both glycolysis and oxidative respiration. <br/><br/>The aged mouse retina shows cellular senescence, accompanied by visual dysfunction and structural changes. The diabetic milieu, both …
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Mechanism on Elongated Mitochondria Formation during Iorn Chelation-Induced Senescent Arrest
… which was employed to damage mtDNA only reformed cristae structure. TTFA, which is known to complexⅡ inhibitor was induced fragmentation of mitochondria. Elongated giant mitochondria also found in old human diploid fibroblast. Next, we examined expression levels of Drp1 and Mfn proteins, which are …
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A Novel Cardiac Function of Sumo2/3 and Senp5 Dependent Pathway and Its Physiological Impact On Congestive Cardiomyopathy
… due to almost complete loss of mitochondrial cristae, and compromised cardiac energy metabolism. These hearts also showed increased deSUMOylation of mitochondrial proteins including dynamin related protein (Drp1), which leads to nuclear translocation of mitochondrial apoptosis inducing factor …
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Identifizierung und Charakterisierung von Proteinen, die Fusion und Teilung von Mitochondrien vermitteln
… unterteilen, oder die Innenmembran verliert die Cristae und fragmentiert. Genetische Hinweise zeigen, dass das Mdm33-Protein vor den Komponenten der Teilungsmaschine der Außenmembran agiert, und dass die mitochondriale Fusion eine Voraussetzung für die Ausbildung der ausgedehnten ringähnlichen …
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Preeclampsia Link to Gestational Hypoxia
… expansion of the endoplasmic reticulum, loss of cristae structure and size in the mitochondria, a shift in mitochondrial respiration away from fatty acid towards glucose metabolism, and increased expression of the anti-inflammatory cytokine tumour necrosis factor α and the anti-angiogenic factors …
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A study of the neurotoxicity of MPTP and analogs in human neuroblastoma SH-SY5Y cells
… of matrix and disorganization of cristae, and abnormal aggregation of filamentous material of the cytoskeleton. MPTP was neurotoxic to the dopaminergic system, inhibiting monoamine oxidase (MAO) activity, and decreasing levels of dopamine (DA) and other catecholamines. In addition, …
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Χορήγηση φαινυτοΐνης για την προφύλαξη του εγκεφάλου από υποξία
… of the mitohondria as well as ruptures of the cristae or of the external membranes, edema and dilatation of the intercellular space between the nerve fibers and cytoplasmic rarefraction of the extensions of the glial cells. In phenytoin groups it was observed in a clearly lesser degree, …
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Structural studies of the mitochondrial F-ATPase
… the enzyme which line the edges of mitochondrial cristae. Therefore, in this thesis, a procedure is described for the purification of dimers of the bovine and yeast F-ATPases. The structure of the bovine dimer has been determined by cryo-em at a resolution of ca. 6.9 Angstrom. This structure …
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Mitochondrial Dysfunction and Stress Responses in CHCHD10 Myopathy and Neurodegeneration
… membrane as evidenced by prominent dilations of cristae containing membranous inclusions. Unexpectedly, the survival of CHCHD10-KI mice depends on a protective stress response mediated by the mitochondrial metalloendopeptidase OMA1. The OMA1 stress response acts both locally within mitochondria, …
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Reorganization of mitochondrial architecture during apoptosis and mitophagy as investigated by correlative microscopy
… morphologies, such as dilution of the matrix and cristae unfolding. This unfolding was found to be linked to a loss of typical ATP synthase dimer organization. A new, comprehensive model of Bax-mediated apoptosis is presented, linking molecular reorganizations of the inner membrane with …
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