Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"craniotomy"”.
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Pre-operative Functional Magnetic Resonance Imaging: Application to Tumour Resection by Awake Craniotomy
… for advanced language mapping during awake craniotomy procedures”, describes the development of a platform that enables behavioural testing to be standardized with respect to pre-operative fMRI, and enables sophisticated testing paradigms to be administered during DCS. The testing platform …
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The Effect of a Novel Multimodal Therapeutic Protocol on Patient Reported Post-Neurosurgical Pain Scores, versus the Current Postoperative Analgesic Practice Employed at a Local South African Hospital – An Investigator Initiated Randomized Controlled Trial
… pain in patients undergoing neurosurgery. Post-craniotomy headache (PCH) remains undertreated due to the cautious use of opioids in this surgical population. Various alternative analgesics such as acetaminophen and scalp blocks are widely utilized for the treatment of PCH, but this is often …
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The Effect of Grapes in Mice with Alzheimer's Disease and Brain Injury
… and TBI in PSAPP mice. Mice received either craniotomy or a moderate TBI. Naïve mice (non-injured) underwent anesthesia. Mice consumed either a grape-enriched or a control diet for 8 weeks. Behavioral tests were administered 2 weeks after injury. CCI mice showed significant motor and memory …
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The Changing Face of Craniopharyngioma Treatment in Young Children and its Challenges at a Single Centre in a Developing World Context
… Of surgical approaches, 60,7% had pterional craniotomy and 39,2% supraorbital keyhole craniotomy. No surgical mortalities occurred but 2 patients had new post-operative neurological deficits. Stereotactic placement of intracystic catheters transitioned to endoscopic. Intracystic treatments …
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Biomechanics of Cranial Decompression Procedures in Traumatic Brain Injury
… are evaluated for alternative hinge and floating craniotomy procedures to facilitate comparison. Main findings of this finite element analysis comparison are that decompressive craniectomy allows for higher maximum brain surface displacement (more herniation) and a corresponding higher average …
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Implantable Bioelectronics with Integrated Shape Actuation for Minimally Invasive Neural Interfacing
… is a highly invasive procedure, requiring a craniotomy larger than the implant area to place the device. In the first section of this work, flexible thin-film electrode arrays are combined with concepts from soft robotics, to realize a large-area electrocorticography device that can change …
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Risk, Outcomes, and Costs in Neurosurgery – The New Frontier in Health Services Research
… as an a priori factor to discourage pursuing craniotomy. Smoking cessation can be considered prior to spine surgery for reasons other then early (30-day) peri-operative morbidity or mortality. Anemia should be regarded as an independent risk factor for peri-operative and post-operative …
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Advances in targeted chemotherapy using MRI-guided focused ultrasound to disrupt the blood-brain barrier
… and reproducible BBB disruption without invasive craniotomy in rats, to enable doxorubicin to accumulate in normal brain at clinically therapeutic levels, and to increase the antitumoral efficacy of doxorubicin in a rodent model of aggressive glioma. Using a microbubble-based ultrasonographic …
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First-In-DOg HISTotripsy for Intracranial Tumors Trial: The FIDOHIST Study
… paradigm, where tumors were approached using craniotomy, partially ablated with histotripsy delivered through the cranial defect, imaged with MRI, and then resected. Dogs were evaluated with clinical, brain MRI, immunopathologic, and genomic examinations before treatment, intraoperatively, and …
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Enzyme Analysis of Oxidatively Modified Proteins Post-TBI
… in all groups (except sham) were subjected to a craniotomy and a moderate TBI via cortical contusion. Post-TBI rats in the saline group received an administration of saline (150mg/kg), and rats in the GCEE treatment group received an administration of GCEE (same dosage). Upon sacrifice, brains …
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Subdural empyema : a clinical study
… burrhole drainage and diminishes the need for craniotomy. Rare cases may even be managed with antibiotics only. It remains important to deal with the source of subdural empyema - paranasal in 31, otogenic in 10, osteitis in 2 and not known in 4 of the patients. Anaerobic organisms (28%), which …
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A New Device for Stereotactic ct-Guided Biopsy of the Canine Brain: Design, Construction, and Needle Placement Accuracy
… targets were identified on CT. After a 5 mm craniotomy, the biopsy needle, with CT monitoring, was progressively introduced into the target. The final needle track distance was measured on CT. The brain was removed and sliced to verify placement of the needle tip within the target and to …
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Integrated Analysis of Molecular and Clinical Features in Melanoma Patients with Brain Metastases
… patients who underwent surgical resection (via craniotomy) between 1991 and 2015 at our institution with bulk RNA-seq data generated from their MBMs. On univariate analysis, the expression of multiple immune gene signatures was associated with improved OS. The gene expression signatures of …
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A COMBINATION THERAPY OF NICOTINAMIDE AND PROGESTERONE FOR FUNCTIONAL RECOVERY FOLLOWING TRAUMATIC BRAIN INJURY
… peanut oil, i.p. over 72 hrs), and compared to a craniotomy only (Sham) group. Following this regimen they were assessed in a battery of behavioral (fine and gross motor, sensory, and cognitive) tasks or a histological assessment at 24 hrs post-injury assessing lesion cavity size, degenerating …
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Transposition of Offending Vessel Using Fibrin glue-coated Teflon Sling in Microvascular Decompression to Treat Glossopharyngeal Neuralgia
… a single experienced surgeon with retromastoid craniotomy via lateral suboccipital approach. Decompression method involved were transposition with glue for eight (36.4%) patients, transposition with sling for seven (31.8%) in those with very tortuous offenders, and interposition for those with …
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Timing of complications following elective craniotomies
… descriptive. Results: A total of 189 elective craniotomy patients were included in our audit for the 2-year period mentioned. In this study 37/189 (19.6%) patients developed 1 or more major complications during the initial 24 hr post-operative period. Of these 37 patients, 31 (83.8% [95% CI …
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Obstetric practice and cephalopelvic disproportion in Glasgow between 1840 and 1900
… of disproportion included caesarean section, craniotomy, forceps, induction of premature labour, symphysiotomy, and turning. Medical practitioners’ decisions were subject to social, medical and scientific factors. Practitioners’ choices were influenced by their experience, reports of …
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Evaluation of the anatomical accuracy of the neuronavigation system “StealthStation” in neurosurgical operations
… the probable diagnosis is a contraindication for craniotomy, or 2b) were poor candidates for craniotomy (over 80 years old or serious comorbidities that were considered contraindications for craniotomy). 28 patients were operated on with each method. Regarding the frameless biopsy technique, we …
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Neuronal and Electrophysiological Markers of Glioma
The research performed in this thesis aims to improve our understanding about one of the most malignant tumors of the human brain – glioma. From the early stages of my career I was confronted with the cruel reality of losing patients due to this devastating disease. The studies performed over the …