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Showing 1 to 20 of 28 for “"coxsackievirus"”.
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Assay and Purification of Coxsackievirus B3
The problem. Which of the available methodologies for the purification for Coxsackie virus B3 (CB3), a Picornavirus provide the highest degree of purity with the greatest yield. The procedure. Quantitative methods for the assay and purification of CB3 were developed. CB3 was propagated in buffalo …
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Host Factors That Influence Coxsackievirus B3 Replication and Pathogenensis
… mortality, and economic burdens yearly. Coxsackievirus (CV) is commonly isolated among enteric viruses and is an etiological agent of hand, foot, and mouth disease, hemorrhagic conjunctivitis, and myocarditis. The virus predominantly infects infants and young children and accounts for 11% …
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UV light inactivation of adenovirus, coxsackievirus and murine norovirus
The overall objective of this research project is to evaluate the efficiency of low-pressure (LP) and medium-pressure (MP) UV light irradiation to inactivate waterborne pathogens that are an increasing concern in drinking water. The inactivation of pathogens depends directly on the total UV dose or …
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Adenosine triphosphate is an allosteric inhibitor of coxsackievirus B3 3Dpol
… the relative affinities of a stalled coxsackievirus elongation complex for non-cognate nucleotides uncovered a mixed inhibition profile of ATP. Among the six picornavirus species tested, this mode of inhibition seems specific to coxsackievirus B3 (CVB3). Engineered mutations in CVB3 …
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Antivirale Therapie gegen Adenoviren mittels löslicher Coxsackievirus- und Adenovirus-Rezeptor-Varianten
… Potential rekombinanter löslicher Varianten des Coxsackievirus- und Adenovirus-Rezeptors (CAR) gegen (Ad) beschrieben. Ein besonderes Augenmerk liegt dabei auf dem Fusionsprotein sCAR-Fc, welches aus dem extrazellulären Bereich des CAR und dem Fc-Teil des humanen IgG1 besteht. 1) Von den …
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The inactivation of Coxsackievirus B5 with monochloramine for safe global water
… people without access to improved water supply. Coxsackievirus, a RNA water-borne pathogen found worldwide, causes a range of human illnesses including diarrheal diseases and myocarditis. Inactivation of water-borne pathogens has been achieved using disinfectants such as hypochlorous acid or free …
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Pathological and genetic analysis of host susceptibility to cardiovirulent coxsackievirus B3 infection in mice
… American myocarditis cases are associated to coxsackievirus group B, type 3 (CVB3) infection. CVB3 infection of mice provides a useful model to study pathogenic mechanism of myocarditis. The objective of this study is to test the hypothesis that susceptibility, during the acute CVB3 infection, …
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Comparative mechanistic study of Coxsackievirus B5 and Human Adenovirus Serotype 2 inactivation by chlorine
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Inactivation kinetics of coxsacieviurs B5 with free chlorine
… viruses remains unknown. One such virus is coxsackievirus. Coxsackievirus, along with other enteroviruses, causes a significant number of infections in the United States. These infections can prove fatal to those with relatively weak immune systems (children, the elderly, women in pregnancy, …
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Role of basic and hydrophobic residues in the poliovirus polymerase elongation complex and the structure of a coxsackievirus polymerase elongation complex
… EC and 2) presents the crystal structure of a coxsackievirus (CV) EC. To determine the role of that several arginines, lysines, and tyrosines play in the PV polymerase, we assessed whether mutations to these residues affect initiation, elongation, or stability of the EC. The data indicates the …
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Auftreten von Autoantikörpern gegen Flavoproteine mit covalent gebundenem Flavinadenindinukleotid bei Patienten mit idiopathischer dilatativer Kardiomyopathie und Myokarditis
… sowohl bei einer Myokarditis, die durch eine Coxsackievirus B3-Infektion bei Mäusen hervorgerufen worden ist, als auch in Sera von Patienten mit einer idiopathischen dilatativen Kardiomyopathie gezeigt werden. <br>Zwar konnten Anti-M7-Antikörper in einer Maus durch eine Coxsackievirus …
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Pharmacology of novel approaches designed to target picornaviral infections
… as identify new compounds from natural sources. Coxsackievirus A9 (CAV9) was used as a typical enterovirus and a plaque reduction assay was used to assess antivirus activity. Both approaches gave promising agents. Fluoxetine and dibucaine caused a complete CAV9 inhibition at low concentrations. …
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Examination of type I IFN mediated regulation of the post-transcriptional antiviral response
… including Vaccinia virus, Influenza virus and Coxsackievirus. Given these findings of rapid mRNA translation to enable a robust IFN antiviral response, and aware that this is an ATP consuming process, we next examined whether IFN-α/β treatment also exerted effects on cell metabolism. Through a …
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The Tradeoffs for a Viral Mutant with Enhanced Replication Speed
… in cultured cells. By sequentially passaging coxsackievirus B3 in cultured cells and collecting the very earliest progeny, we selected for increased replication speed. We found that a single mutation in a viral capsid protein, VP1-F106L, was sufficient for the fast-replication phenotype. …
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Targeting of adenovirus serotype 5 infectivity to EGFRvIII-expressing cells using a bispecific CAR-scFv.
… fiber protein, known as the knob domain, to the coxsackievirus and adenovirus receptor (CAR), which is expressed on various cell types. Although we attempted three different approaches to try and target the virus using MR1, including direct incorporation of the scFv into the knob domain of …
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Sensing of Picornavirus Infections
… that encephalomyocarditis virus (EMCV) and coxsackievirus B3 (CVB3), picornaviruses of the cardiovirus and the enterovirus genus respectively, are sensed by both MDA-5 and RIG-I. Sensing of these viruses in macrophages leads to the expression of type I IFN early after infection with IFNβ …
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Molecular Basis of Adaptation of Enteroviruses to Different Cancer Cell Lines
… including Echovirus 11 (E11), bind to DAF; coxsackievirus A9 (CVA9) utilizes an RGD motif to bind to integrins, particularly αvβ6. Some isolates of CVA9 also bind to heparan sulfate proteoglycans (HSPG). This thesis describes work designed to improve our understanding of CVA9 and echovirus …
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Development of new parameters for structure determination and dynamic investigations on biomacromolecules by NMR
… D (SLD) in the regulatory 5'-cloverleaf of coxsackievirus 3B.
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