Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 168 for “"cox-2"”.
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Augmenting Anti-Tumor Immunity by Targeting Macrophage Cox-2 in Breast Cancer
Cyclooxygenase-2 (COX-2) expression is associated with poor prognosis across a range of human cancers, including breast. While the contributions of tumor cell-derived COX-2 are well studied, those of the stroma remain ill-defined. Macrophages, an essential component of the tumor microenvironment, …
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RNA Interference and cyclooxygenase-2 (COX-2) regulation in colon cancer cells
… between RNAi and the enzyme cyclooxygenase-2 (COX-2) in the field of colorectal cancer (CRC), since it has been established that the transition adenoma-adenocarcinoma and the progression of CRC depend on aberrant constitutive expression of COX-2 gene. In fact, overexpressed COX-2 is involved in …
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Upregulation of COX-2 protein expression in porcine macula densa with L-NAME treatment
… OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] COX-2 inhibitors are newly developed drugs which are widely used for controlling pain and inflammation. Blocking this enzyme impedes the production of the prostaglandins that cause pain and swelling. However certain prostaglandins are also important …
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Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions
… therapy and diagnosis. Cyclooxygenase-2 (COX-2), an enzyme involved in the biosynthesis of a lipid inflammatory mediator, prostaglandin E2 (PGE2), is over expressed in macrophages infiltrating the pathological site. Inhibition of PGE2 leads to reduced inflammation, pain and macrophage …
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Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions
… therapy and diagnosis. Cyclooxygenase-2 (COX-2), an enzyme involved in the biosynthesis of a lipid inflammatory mediator, prostaglandin E2 (PGE2), is over expressed in macrophages infiltrating the pathological site. Inhibition of PGE2 leads to reduced inflammation, pain and macrophage …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
… to block metastasis. Cyclooxygenase-2 (COX-2) and receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B (RANKL/RANK) pathway mediate an inflammatory response linked to breast cancer progression. However, the mechanism of how COX-2 and RANKL/RANK …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
… to block metastasis. Cyclooxygenase-2 (COX-2) and receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B (RANKL/RANK) pathway mediate an inflammatory response linked to breast cancer progression. However, the mechanism of how COX-2 and RANKL/RANK …
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Concomitant Suppression Of Both Cox-1 And Cox-2 Is Not Sufficient To Cause Gastroenteropathy Associated With Chronic Nsaid Use
… simultaneously inhibiting both cyclooxygenases (COX) -1 and -2 to suppress prostaglandin synthesis. Operating under this assumption, I had developed a novel mouse model of inducible COX-1 + COX-2 deletion to complement our lab’s chronic NSAID exposure model. These COX double-knockout mice …
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Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
<p>Celecoxib nanoemulsion (CXB-NE) has been developed as a macrophage targeted analgesics by Dr. Janjic and her team at Duquesne University, (Janjic et al, 2018; Liu et al, 2020; Saleem et al, 2019b; Vasudeva et al, 2014). The CXB-NE nanoemulsion carrying a Nonsteroidal Anti-inflammatory (NSAID) …
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Παθοβιοχημεία της εκφύλισης μηνίσκου στον άνθρωπο : συμμετοχή του σηματοδοτικού άξονα p38 MARK-NF-kB και της Κυκλο-οξυγενάσης 2 (COX-2)
… NF-kB (με τα διμερή p50-p65) καθώς και της COX-2 σε μηνισκικές ρήξεις, και διερευνήθηκε η συμμετοχή τους στην ανάπτυξη εκφύλισης. Τα ευρήματα απέδειξαν αυξημένη έκφραση του άξονα p38-NF-kB και της COX-2 στον αποδιοργανωμένο και εκφυλισμένο ινοχόνδρινο μηνισκικό ιστό, υποδεικνύοντας ένα ρόλο …
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Alterações vasculares em ratos expostos ao diabetes materno: Contribuição das prostaglandinas derivadas da COX-2 e sua repercussão em diferentes idades
… de disfunção, foram utilizados inibidores da COX-1 e 2 (indometacina) ou da COX-2 (NS-398), onde ambos aumentaram o relaxamento e reduziram a contratilidade, significativamente, nas artérias dos ratos STZ12M. A participação do TXA2 e de outros derivados vasoconstritores da COX-2, foi …
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Exposição à Hiperglicemia Materna Induz Disfunção Endotelial Em Artérias de Resistência da Prole Adulta. Papel das Prostaglandinas Derivadas da Cox-2.
… e se a ativação das vias das ciclooxigenases (COX) está envolvida neste efeito. O diabetes materno foi induzido por estreptozotocina no dia 7º de gestação em ratas Wistar. Estudos de reatividade vascular foram realizados para analisar o relaxamento à acetilcolina (ACh) e a contração à …
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Non-steriodal anti-inflammatory drug-mediated regulation of COX-2 and EP3 receptor expression in the M-1 murine cortical collecting duct cell line.
… isoform specific antibodies, we have localized COX-1 and -2 immunoreactivity to all cell types of the murine M-1 CCD cell line. By, immunohistochemistry, both COX-1 and COX-2 were localized to the intercalated cells of the collecting duct on paraffin embedded mouse kidney sections. When COX …
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Correlation of Cyclooxygenase-2 and Microvessel Density with Prognosis in Transitional Cell Carcinoma of the Upper Urinary Tract
PURPOSE: Cyclooxygenase (COX)-2 plays an important role in cancer progression by affecting tumor cell proliferation, resistance to apoptosis, angiogenesis, and tumor invasion in several types of cancers. However, studies about COX-2 expression in transitional cell carcinoma of the upper urinary …
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Untersuchung der Expression von Cyclooxygenase-2, VEGF und der Gefäßdichte im Nierenzellkarzinom
Die Cyclooxygenase-2 (COX-2) hat Einfluß auf die maligne Transformation von Zellen, deren Proliferation, Migration und Invasion ins Gewebe, auf die Apoptose und auf die Gefäßneubildung in Tumoren. Letztere ist bei der Tumorentstehung ein fundamentaler Prozeß, und VEGF nimmt unter den daran …
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The relationship between nitric oxide synthase (NOS) and cyclooxygenase (COX) in the control of cervical ripening and parturition
… if there is relationship between iNOS and COX-2 in the control of cervical ripening and parturition. Cervices were obtained from estrus and timed pregnant Sprague-Dawley rats (n = 4-10 per group) under normal conditions; or after treating with LPS (100ƒÝg i.p.), Onapristone (3mg/rat), …
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The Role of the Rna‐Binding Protein Hur in Colorectal Carcinogenesis
… in colorectal cancer is cyclooxygenase-2 (COX-2). This enzyme catalyzes the rate-limiting step of increased prostaglandin formation in inflammatory states. Normally COX-2 expression levels are tightly regulated through transcriptional and post-transcriptional mechanisms, allowing for rapid …
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Cyclooxygenase-2 is Associated with Cadmium-induced ICAM-1 Expression in Brain Endothelial Cell
… also, we observed Cd induces cyclooxygenase-2 (COX-2) expression, and thereby prostaglandin E2 (PGE₂) production in bEnd.3. Based on the previous report that PGE₂ is one of the key regulators in the expression of cell adhesion molecule, in this study, we explored the possible role of COX-2 in …
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Biomarcadores moleculares no esôfago de Barrett: análise comparativa da imunoexpressão tecidual do p53, c-erbB-2, E-caderina, COX-2 e KI-67, na esofagite por refluxo, no esôfago de Barrett e no adenocarcinoma associado ao esôfago de Barrett
… biomarcadores: p53, c-erbB-2, Ecaderina, COX 2 e Ki-67. As imunorreações qualitativas com p53, COX-2 e c-erbB-2 revelaram maior expressão no grupo III, contrastando com a positividade menor e decrescente dos grupos II e I (p<0,001; p=0,002; p<0,001, respectivamente). O escore …
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