Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"covariation analysis"”.
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Mechanistic Studies of the Activation of Ubiquitin-Conjugating Enzymes by Ring-Type Ubiquitin Ligases
… thioester bond. Using the Statistical Coupling Analysis, a pairwise residue covariation analysis, we observe that E2 enzymes have a set of residues that vary as a group throughout evolution. Extensive mutagenesis of the E2 enzyme UbcH5b, including its covarying residues, yield mutants that can …
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The plastid caseinolytic protease complex as a model for cytonuclear coevolution
… the sequences of component subunits. This covariation is strong enough to be used as a method to predict which proteins are connected physically and/or functionally. The coevolution between multiple genomes in eukaryotic cells is known as cytonuclear coevolution. Plants, for example, have a …
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Progress Towards Integrated Models of HCV Dynamics
… proteins. Some of the challenges to the study of covariation in HCV MSAs were identified, and we describe a novel method of calculating covariation which addresses some of these issues, particularly the problem of phylogenetic covariance. While an integrated dynamic model of HCV remains far from …