Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"course of disease"”.
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Time Course of Disease Progression of PRPF31-Mediated Retinitis Pigmentosa
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Impact of dietary tomato intake on prostate cancer throughout the course of disease development and progression in a transgenic mouse model
Despite decreasing trends of overall diagnosis, prostate cancer (PCa) is the most commonly diagnosed male cancer in the United States. However, the decrease in total and early stage PCa masks the disproportionate increased trend in the incidence of advanced stage disease. Interestingly, evidence …
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Marcadores das hepatites tipo A e B em 91 pacientes com icterícia: correlação clínico-patológica
Markers of viral hepatitis types A and B were investigated in 91 patients. Results allowed the patients to be classified into 4 group, the first (37 patients) characterized as hepatitis A, the second (35 patients) as hepatitis B, the third (11 patients) with neither A nor B markers and the fourth …
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Diagnostic and prognostic aspects of anti-neutrophil cytoplasmic antibodies in systemic vasculitis
… the diagnostic and prognostic significance of anti-neutrophil cytoplasmic antibodies (ANCA) in systemic vasculitis is investigated. The clinical significance of a capture enzyme-linked immunosorbent assay (ELISA) based on the monoclonal antibody 4A3 for detection of antibodies against …
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Functional Characterization of the HIV-1 NEF Acidic Cluster
… factors have hastened the epidemic spread of HIV in Africa and in third world countries where many individuals do not have access to appropriate healthcare. Vaccines have, as of yet, been unsuccessful as a preventive measure; however, new measures, including peptide inhibitors and …
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Equine Protozoal Myeloencephalitis. Preliminary Investigation of Protozoan-Host interactions in the horse
… most frequently diagnosed neurologic disorder of horses in the united states, which is caused by the protozoan organism Sarcocystis neurona. The disease has a profound impact on the American Horse Industry. This impact includes prolonged and expensive treatment without a guaranteed return to a …
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Hyperpolarized 3He-diffusion MRI in evaluation of lung structure in emphysema. Validation and development of the method
Abstract COPD is a major cause of chronic morbidity and mortality throughout the world. It is a preventable and treatable disease. Smoking is the most commonly encountered risk factor for COPD and the habit now unfortunately starts at earlier ages than before. There is a strong necessity to …
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Outcomes of children with biopsy-proven Langerhans cell histiocytosis (LCH) treated at the Red Cross War Memorial Children's Hospital from 1998 – 2017
… disorder characterised by the infiltration of a single organ or multiple organs by cells phenotypically similar to Langerhans cells. The number and type of systems involved affect the outcome and the longer the maintenance chemotherapy the longer the periods of remission. a. Rationale: This …
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Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease
Alzheimer’s disease (AD), the most common cause of dementia, is a growing concern. As the life expectancy increases across the globe, the number of affected people is estimated to reach 100 million by 2050. Efforts to develop effective treatments for humans have mostly been based on the assumption …
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Approaches to developing clinically useful Bayesian risk prediction models
Prediction of the presence of disease (diagnosis) or an event in the future course of disease (prognosis) becomes increasingly important in the current era of personalised medicine. Both tasks (diagnosis and prognosis) are supported using (risk) prediction models. Such models usually combine …
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Improving quality of care in inflammatory bowel disease: treatment targets and body composition
… Quality care for people with inflammatory bowel disease (IBD) aims to modify the course of disease and normalise quality of life (QoL). Treatment directed at objective inflammation has been shown to improve outcomes in IBD, yet represents a paradigm shift for clinicians trained to manage symptoms …
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Effects of distillers dried grains with solubles and dietary fiber on the intestinal health of young pigs and chicks
The objective of this research was to determine the value of dietary fiber (DF) from distillers dried grains with solubles (DDGS) on the promotion of intestinal health in young pigs and chicks. Furthermore, purified sources of DF were used in pigs to elucidate whether the soluble or insoluble …
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The application of Bayesian adaptive design and Markov model in clinical trials
… trials, the strategy is to reduce the allocation of patients to non-informative doses and also save the trial cost. Bayesian adaptive dose finding design has the ability to utilize accumulating data obtained in real time to alter the course of the trial, thereby enabling dynamic allocation to …
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Role of Hepatic Lipoprotein Receptor-related Protein 1 (LRP-1) on Amyloid Beta Pathology in a Mouse Model of Amyloidosis
<p>Title: Role of hepatic lipoprotein receptor related protein 1 on amyloid beta pathology in a mouse model of amyloidosis.</p> <p>Alzheimer’s disease (AD) is a chronic neurodegenerative disease caused by an abundance of extracellular neuritic plaques containing enormous amounts of amyloid beta …
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Biofilm formation and virulence of Streptococcus pneumoniae
… lineage or serotype with propensity to cause disease; as well as in the identification of specific molecular determinants of distinct virulence phenotypes. Formation of biofilms is an important step in pneumococcal pathogenesis, as they serve as reservoirs of infection and organisms within …
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Investigating novel therapeutic approaches and targets to prevent synapse degeneration
Neurodegenerative diseases are associated with extensive physical and mental debilitation, significant costs to the healthcare system, as well as great emotional and financial burden to the patients, their families and care providers. Despite progress in our understanding of the mechanisms behind …
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Systems pathology: a bottom-up approach for understanding fibroblast-epithelial interactions in breast cancer
… in the diagnosis, prognosis, and treatment of breast cancer. We were motivated to develop a new approach for both studying the etiology of heterogeneity in breast cancer phenotypes and predicting the course of disease in tumor biopsies using an emerging chemical imaging technology. It has …
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In vivo pathology markers in tauopathies: prognostic and diagnostic implications
… tauopathies include Alzheimer’s disease, frontotemporal dementia (half due to tauopathy), and progressive supranuclear palsy (PSP). In addition to abnormal accumulation of tau protein, they are each characterised by neuroinflammation, with increasing evidence that the …
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