Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 229 for “"coupling reactions"”.
-
Novel copper-catalysed coupling reactions of diphenylmethane
… ethane were present as side products of the coupling reaction. After failing multiple attempts to synthesise fendiline using the proposed synthetic route, the focus of the project shifted to the research and development of hetero- and homo- cross-coupling reactions of the Gilman reagent. …
-
Mechanistic studies on palladium-catalyzed coupling reactions
… the individual steps of palladium-catalyzed coupling reactions. In one case, the oxidative addition of PhX (X = I, Br, Cl) to the complexes Pd(PtBu3)2 (1), Pd(1-AdPtBu2)2(2), Pd(CyPtBu2)2 (3), and Pd(PCy3)2 (4) (1-Ad = 1-adamantyl, Cy = cyclohexyl) was studied to determine the effect of …
-
Coupling reactions using flow-generated diazo compounds
… diazo compounds and their application in coupling reactions. In the first chapter, an introduction into the structure and reactivity of diazo compounds is provided, as well as a discussion of currently available methods for their generation. The second chapter describes the coupling of …
-
Cross-coupling reactions of unactivated alkyl halides
… of palladium- or nickel-catalyzed cross-coupling reactions using unactivated alkyl electrophiles (e.g., halides and sulfonates). Although aryl and alkenyl electrophiles have been commonly used in such processes, the utility of alkyl substrates has been underdeveloped, and merits further …
-
Metallodendrimers as catalysts for C-C coupling reactions
… synthesized following Schiff base condensation reactions. The ferrocenylimine ligands L1 and L2 were prepared from ferrocenecarboxaldehyde and 1,3-diaminopropane or DAB-4-(NH2)4, while the G1 dendrimeric N,N′ ligands L3 and L4 were prepared from DAB-4-amine and 2- pyridinecarboxaldehyde or …
-
METAL-CATALYSED CROSS-COUPLING REACTIONS OF NITROGEN HETEROCYCLES
… imidazole and pyrrole. The products of these reactions then undergo palladium-catalysed C-C cross-couplings with aryl or heteroarylboronic acids under Suzuki-Miyaura conditions to provide a rapid entry to tris(hetero)aryl scaffolds comprising two or three N-heterocyclic rings. The sequential …
-
Studies of Novel Transition-Metal-Catalyzed Oxidative Coupling Reactions
Transition-metal-catalyzed oxidative coupling reactions are important tools for the construction of carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds from simple starting materials. A series of novel and synthetically useful reactions have been developed and are herein described.
-
Palladium catalyzed cross-coupling reactions of allyl- and vinylsilanes
Palladium-catalyzed cross-coupling of γ-substituted allylic silanolates with aryl bromides was investigated. It was discovered that γ-selectivity is heavily influenced by the substituents at silicon. It is proposed that undergoing an activated pathway significantly lowers the selectivity of the …
-
Nickel precatalysts as enabling tools for catalytic coupling reactions
… room temperature, internally selective coupling of substituted benzyl chlorides with terminal alkenes. This reaction, which employs a terminal alkene as an alkenylmetal equivalent, provides rapid, convergent access to substituted allylbenzene derivatives in high yield and with …
-
Transition metal-catalyzed cross-coupling reactions of functionalized organometallic reagents
… been found for a versatile nickel-catalyzed crosscoupling reaction in the presence of an electron deficient styrene promoter, allowing for the first time: · effective coupling of readily available functionalized alkylzinc halides and benzylic zinc bromides with functionalized alkyl iodides in the …
-
Photoredox C–C Cross-Coupling Reactions using Boronic Acid Derivatives
… and subsequently engage them in C–C cross-coupling reactions. In the first chapter, an introduction to photoredox catalysis and organoboron reagents is provided, as well as a discussion on the key mechanistic aspects of photoredox catalysed C–C cross-coupling reactions. The second chapter …
-
Development and application of transition metal-catalyzed cross-coupling reactions
Chapter 1. PALLADIUM-CATALYZED REGIOSELECTIVE HYDRODEBROMINATION OF DIBROMOINDOLES A novel approach to the selective preparation of 4-bromoindoles has been developed via a Pd-catalyzed reaction. A variety of 4,6-dibromoindoles, which are prepared via Cu-catalyzed chemoselective C-N bond-forming …
-
Palladium-catalyzed C-N and C-O cross-coupling reactions
… its dialkyl- or diarylbiaryl analogues. The C-N coupling was efficient for a wide range of (hetero)aryl chlorides and bromides under mild conditions. Chapter 2: This chapter relates the development of the Pd-catalyzed C-O coupling of primary alkyl alcohols. The reaction of primary aliphatic …
-
DEVELOPMENT OF BASE METAL-CATALYZED HYDROGEN TRANSFER AND CROSS-COUPLING REACTIONS
… is focused on (i) the use of iron catalysts for reactions involving hydrogen transfer and (ii) the development of nickel-catalysed C-heteroatom coupling reactions following the ‘metallaphotoredox’ approach exploiting readily available organic photocatalysts. Thanks to their attractive features, …
-
Intramolecular Anodic Olefin Coupling Reactions: Synthesis Of Nitrogen- And Oxygen-Heterocycles
… to be a powerful method for initiating umpolung reactions that allow the coupling of two nucleophilic functional groups. Most of the work in this area concentrates on making carbon-carbon bond. Hence, the reactions are usually terminated with olefin nucleophiles. The use of heteroatom-based …
-
Nickel-catalyzed cross-coupling reactions involving secondary and tertiary alkyl nucleophiles
… introduction of transition metal-catalyzed cross-coupling reactions has been given. These transition metal-catalyzed C-C bond forming reactions have been used extensively in organic synthesis. Among them, C(sp2)-C(sp2) bond forming reactions have been widely studied over decades. More recently, …
-
Palladium-Catalyzed Alkenylsilanol Cross -Coupling Reactions: Method Development and Mechanistic Analysis
… as the turnover-limiting step for these cross-coupling reactions.
-
Mechanistic Elucidation of M-PR2NRʹ2 Catalysts for Hydrofunctionalization and Cross Coupling Reactions
… transformations. Alkyne hydrofunctionalization reactions, including hydroamination and hydroalkoxylation, were previously catalyzed with [Ru(Cp/Cp*)(PR2NRʹ2)(MeCN)]PF6 catalysts. However, validation of the proposed mechanistic pathway for these complexes has not yet been realized. Investigation …
-
Development and Applications of Pd Catalysts for C-N Cross-Coupling Reactions
… excellent reactivity and efficiency in the coupling of a variety of amides and anilines with aryl chlorides. Chapter 2 A new class of one-component Pd precatalysts bearing biarylphosphine ligands is described. These precatalysts are air- and thermally-stable, are easily-activated under …
Page 1 of 12