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Showing 1 to 20 of 180 for “"coupling reaction"”.
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Development of organosilicon cross-coupling reaction
Use of palladium catalyzed cross-couplings have found widespread use in the pharmaceutical industry and there is a significant ongoing effort to either improve or devise new synthetic strategies to help build complex biologically active compounds. This is a study for advancing the use of silanols …
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Mechanistic studies on palladium-catalyzed C-N cross-coupling reaction
… on the palladium catalyzed C-N bond-forming reaction were carried out to generate a more complete understanding of the catalytic cycle. To understand this reaction, several kinetic studies employing simple aryl halide and amine coupling partners were performed to elucidate unknown reaction …
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IMPROVING THE SCOPE AND UNDERSTANDING OF THE SYMMETRIC AND ASYMMETRIC SUZUKI COUPLING REACTION
… into the Symmetric and Asymmetric Suzuki cross-coupling reaction have been described. A new reaction protocol has been developed in which isolated pre-activated sodium trihydroxyarylborate salts were employed as the organoboron coupling partner, resulting in a more convenient and …
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Studies on the Silanol-Based Cross-Coupling Reaction: (1) Development of Methods for the Synthesis of Aryl and Heteroaryldimethysilanols, (2) Expansion of the Substrate Scope of the Cross-Coupling Reaction and (3) Investigations on the Transmetalation of Organosilanols to Transition Metals
… designed, synthesized and subjected to the cross-coupling reaction. A clear preference for formation of the cross-coupling products was observed in these investigations.
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[3+2]-Cycloadditions of Azomethine Imines and Ynolates and Progress Towards a Radical Three-Component Cross-Coupling Reaction
… second chapter describes attempts to render the reaction asymmetric, which proved to be difficult. Future ideas to improve yields and to render the reaction asymmetric are also described. The last chapter involves progress towards a novel three-component, enantioselective radical cross-coupling …
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A Stereospecific Pd-Catalyzed Suzuki Cross-Coupling Reaction and a Statistical Study of the Ligand's Role in Stereoselection
… of palladium-catalyzed carbon-carbon cross-coupling reactions has profoundly influenced the manner through which we approach the synthesis of complex organic molecules. Among established cross-coupling reactions, which include Kumada, Negishi, and Stille reactions, the Suzuki cross-coupling …
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Sequential cycloadditions for the synthesis of taxoid mimics and stereoselective synthesis of tamoxifen analogues via a new carbomagnesiation-palladium coupling reaction
… The strategy involved two sequential Diels-Alder reactions to form the ABC ring system. The synthesis of aromatic analogue 19 was abandoned due to the lack of regioselectivity and low yields in the Diels-Alder reaction. More progress was made in the synthesis of norbornane analogue 20. In situ …
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Transmetalation from boronic esters to arylpalladium complexes without prior hydrolysis – mechanistic studies and preparative applications in the anhydrous, Suzuki-Miyaura cross-coupling reaction
… development of transition-metal catalyzed, cross-coupling reactions has fundamentally changed the way chemists think about C–C bond formation. Within the class of transition-metal catalyzed, cross coupling reactions, the Suzuki-Miyaura reaction has emerged as the most popular method because of the …
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Transition metal-catalyzed cross-coupling reactions of functionalized organometallic reagents
In summary, reaction conditions have been found for a versatile nickel-catalyzed crosscoupling reaction in the presence of an electron deficient styrene promoter, allowing for the first time: · effective coupling of readily available functionalized alkylzinc halides and benzylic zinc bromides with …
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Development and application of palladium-catalyzed carbon-nitrogen bond forming reactions
Chapter 1. Pd-Catalyzed Cross-Coupling of a-Substituted Optically Active Amines with Aryl Bromides. The palladium-catalyzed coupling reaction of enantiomerically enriched a-substituted amines with aryl bromides is described. The choice of ligand in the palladium-catalyzed coupling reaction is …
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The Multicomponent Synthesis of Pyrroles from Cylcopropane S Using a One Pot Pd(0) Catalyzed Dehydrocarbonylation Protocol
… efficiently synthesized using a three component coupling reaction between a hydroxylamine, aldehyde and cyclopropane diester. This affords the desired heterocycle efficiently with a wide variety of substitution. When one esters bears an allyl group a Tsuji dehydrocarbonylation reaction may take …
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STEREOSPECIFIC SUZUKI-MIYAURA CROSS-COUPLING OF CHIRAL BENZYLIC BORONIC ESTERS AND VINYL BROMIDES
The Suzuki-Miyaura cross-coupling reaction is a powerful method for the construction of carbon-carbon bonds in academia and industry. Despite extensive research in this area and the significance of the reaction, it is most often employed to prepare flat, Csp2-Csp2 bonds between two aryl groups. …
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The effect of fluorination on the surface chemistry of adsorbate-metal systems
… and $-$F) on the kinetics of the phenyl coupling reaction on the Cu(111) surface has been studied. The electron withdrawing fluorine group in the meta or para position of the phenyl ring was shown to lower the activation barrier to phenyl coupling while fluorine in the ortho position …
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Diastereoselective nickel-catalyzed reductive coupling of alkynes and aldehydes and application towards the B-type amphidinolides
… stereoselective nickel-catalyzed reductive coupling reactions of alkynes and aldehydes to the synthesis of complex natural product targets was explored. The "B-Type" amphidinolides were selected as ideal targets owing to their molecular complexity and the paucity of synthetically viable …
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Nickel-catalyzed Suzuki-Miyaura reactions of unactivated halides with alkyl boranes and planar-chiral borabenzene catalysts for Diels-Alder reactions
… the expansion in scope of a nickel-catalyzed coupling reaction of unactivated alkyl bromides and alkyl boranes to include unactivated alkyl chlorides. The new method is adapted for use outside of a glove box and is also found to be applicable not only to the coupling of primary chlorides, but …
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Nickel-catalyzed preparation of acrylamides from alpha olefins and isocyanates ; Synthetic studies toward ripostatin A
… carbene ligand IPr, the nickel(0)-catalyzed coupling reaction of a-olefins and branched aliphatic isocyanates provides c,-unsaturated amides arising from preferential C-C bond formation at the 2-position of the olefin. This sense of regioselectivity contrasts with the observed carboxamidation …
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